Levels, and Risk of Lung Cancer in EPIC Genetic Polymorphisms in 15q25 and 19q13 Loci, Cotinine

Backgrounds:Multiple polymorphisms affecting smoking behavior have been identified through genomewide association studies. Circulating levels of the nicotine metabolite cotinine is a marker of recent smoking exposure. Hence, genetic variants influencing smoking behavior are expected to be associated with cotinine

[1]  J. Hokanson,et al.  Genome-wide association study of smoking behaviours in patients with COPD , 2012 .

[2]  F. Clavel-Chapelon,et al.  Smoking, Secondhand Smoke, and Cotinine Levels in a Subset of EPIC Cohort , 2011, Cancer Epidemiology, Biomarkers & Prevention.

[3]  William Wheeler,et al.  Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD , 2010, PLoS genetics.

[4]  Paul Brennan,et al.  Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. , 2010, Journal of the National Cancer Institute.

[5]  F. Clavel-Chapelon,et al.  Serum B vitamin levels and risk of lung cancer. , 2010, JAMA.

[6]  C. Gieger,et al.  Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior , 2010, Nature Genetics.

[7]  Ming D. Li,et al.  Genome-wide meta-analyses identify multiple loci associated with smoking behavior , 2010, Nature Genetics.

[8]  C. Gieger,et al.  Sequence variants at CHRNB 3 – CHRNA 6 and CYP 2 A 6 affect smoking behavior , 2010 .

[9]  L. Peltonen,et al.  Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. , 2009, Human molecular genetics.

[10]  P. Ueland,et al.  Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry. , 2009, Rapid communications in mass spectrometry : RCM.

[11]  Jian-Min Yuan,et al.  Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers. , 2009, Cancer research.

[12]  William Wheeler,et al.  Genome-Wide and Candidate Gene Association Study of Cigarette Smoking Behaviors , 2009, PloS one.

[13]  T. Church,et al.  A Prospectively Measured Serum Biomarker for a Tobacco-Specific Carcinogen and Lung Cancer in Smokers , 2009, Cancer Epidemiology Biomarkers & Prevention.

[14]  M. Tremblay,et al.  The accuracy of self-reported smoking: a systematic review of the relationship between self-reported and cotinine-assessed smoking status. , 2009, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[15]  N. Benowitz,et al.  Nicotine chemistry, metabolism, kinetics and biomarkers. , 2009, Handbook of experimental pharmacology.

[16]  Maarit Tiirikainen,et al.  Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. , 2008, Cancer research.

[17]  J. Mindell,et al.  Assessing smoking status in children, adolescents and adults: cotinine cut-points revisited. , 2008, Addiction.

[18]  S. Vollset,et al.  Angiography : A Randomized Controlled Trial CoronaryWith Homocysteine-Lowering B Vitamins After Mortality and Cardiovascular Events in Patients Treated , 2008 .

[19]  H. Wit Faculty Opinions recommendation of Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. , 2008 .

[20]  Daniel F. Gudbjartsson,et al.  A variant associated with nicotine dependence, lung cancer and peripheral arterial disease , 2008, Nature.

[21]  Paolo Vineis,et al.  A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 , 2008, Nature.

[22]  Y. Mineur,et al.  Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction. , 2008, Biochemical Pharmacology.

[23]  Jonathan A C Sterne,et al.  The impact of residual and unmeasured confounding in epidemiologic studies: a simulation study. , 2007, American journal of epidemiology.

[24]  J. Lubin,et al.  The Association of a Tobacco-Specific Biomarker and Cigarette Consumption and Its Dependence on Host Characteristics , 2007, Cancer Epidemiology Biomarkers & Prevention.

[25]  Scott F. Saccone,et al.  Novel genes identified in a high-density genome wide association study for nicotine dependence. , 2007, Human molecular genetics.

[26]  J. Samet,et al.  Cotinine Concentration in Smokers from Different Countries: Relationship with Amount Smoked and Cigarette Type , 2006, Cancer Epidemiology Biomarkers & Prevention.

[27]  R. Peto,et al.  Serum Cotinine Level as Predictor of Lung Cancer Risk , 2006, Cancer Epidemiology Biomarkers & Prevention.

[28]  Stephen S. Hecht,et al.  Relationships between Cigarette Consumption and Biomarkers of Tobacco Toxin Exposure , 2005, Cancer Epidemiology Biomarkers & Prevention.

[29]  R. Tyndale,et al.  Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence , 2005, Clinical pharmacology and therapeutics.

[30]  Neal L. Benowitz,et al.  Metabolism and Disposition Kinetics of Nicotine , 2005, Pharmacological Reviews.

[31]  J. Samet,et al.  Determinants of salivary cotinine levels among current smokers in Mexico. , 2004, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[32]  N E Day,et al.  European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection , 2002, Public Health Nutrition.

[33]  W James Gauderman,et al.  Sample size requirements for matched case‐control studies of gene–environment interaction , 2002, Statistics in medicine.

[34]  M. Kogevinas,et al.  Levelling-off of the risk of lung and bladder cancer in heavy smokers: an analysis based on multicentric case-control studies and a metabolic interpretation. , 2000, Mutation research.

[35]  T. Perneger,et al.  Saliva cotinine levels in smokers and nonsmokers. , 2000, American journal of epidemiology.

[36]  R. Collins,et al.  Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies. , 1999, American journal of epidemiology.

[37]  M. Law,et al.  The dose-response relationship between cigarette consumption, biochemical markers and risk of lung cancer. , 1997, British Journal of Cancer.

[38]  Alan D. Lopez,et al.  At least one in seven cases of cancer is caused by smoking. Global estimates for 1985 , 1994, International journal of cancer.

[39]  J. Jobe,et al.  Saliva cotinine and recent smoking--evidence for a nonlinear relationship. , 1993, Public health reports.

[40]  B Rosner,et al.  Correction of logistic regression relative risk estimates and confidence intervals for random within-person measurement error. , 1992, American journal of epidemiology.

[41]  P. Jacob,et al.  Cotinine in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers. , 1988, American journal of public health.

[42]  J. Palca Nicotine addiction , 1988, Nature.

[43]  J. Boreham,et al.  Inhaling and lung cancer: an anomaly explained. , 1983, British medical journal.

[44]  R. Doll,et al.  Smoking and carcinoma of the lung; preliminary report. , 1950, British medical journal.