NMR Investigations of the Solution Conformations of Deoxynucleotidyl (3′-5′) Arabinonucleosides

Abstract The solution conformations of all eight deoxynucleotidyl (3′-5′) arabinonucleosides containing 9-B-D-arabinofuranosyladenine and 1-B-D-arabinonfuranosylcytosine have been analyzed by NMR methods and compared to dinucleoside monophosphates containing the corresponding deoxyriboside units.

[1]  Jacques H. van Boom,et al.  Conformational analysis of oligoarabinonucleotides. An NMR and CD study , 1983, Nucleic Acids Res..

[2]  C. L. Bell,et al.  Synthesis of deoxyribonucleotidyl(3'5')arabinonucleosides , 1983 .

[3]  D. Kufe,et al.  Effect of ARA-C incorporation on deoxyribonucleic acid synthesis in cells. , 1982, Biochemical pharmacology.

[4]  F. D. Leeuw,et al.  The relationship between proton–proton NMR coupling constants and substituent electronegativities. II—conformational analysis of the sugar ring in nucleosides and nucleotides in solution using a generalized Karplus equation , 1981 .

[5]  J. V. van Boom,et al.  Conformational characteristics of the trinucleoside diphosphate dApdApdA and its constituents from nuclear magnetic resonance and circular dichroism studies. Extrapolation to the stacked conformers. , 1980, European journal of biochemistry.

[6]  J. Byrnes,et al.  Mechanism of inhibition of deoxyribonucleic acid synthesis by 1-beta-D-arabinofuranosyladenosine triphosphate and its potentiation by 6-mercaptopurine ribonucleoside 5'-monophosphate. , 1980, Biochemistry.

[7]  Cornelis Altona,et al.  Empirical Correlations Between Conformational Parameters in β‐D‐Furanoside Fragments Derived from a Statistical Survey of Crystal Structures of Nucleic Acid Constituents Full Description of Nucleoside Molecular Geometries in Terms of Four Parameters , 1980 .

[8]  F. D. Leeuw,et al.  The relationship between proton-proton NMR coupling constants and substituent electronegativities—I : An empirical generalization of the karplus equation , 1980 .

[9]  R H Sarma,et al.  Intimate details of the conformational characteristics of deoxyribodinucleoside monophosphates in aqueous solution. , 1977, Journal of the American Chemical Society.

[10]  N. Cozzarelli The mechanism of action of inhibitors of DNA synthesis. , 1977, Annual review of biochemistry.

[11]  S. Danyluk,et al.  Conformational properties of purine-pyrimidine and pyrimidine-purine dinucleoside monophosphates. , 1977, Biochemistry.

[12]  S. Danyluk,et al.  Conformational properties of dinucleoside monophosphates in solution: dipurines and dipyrimidines. , 1976, Biochemistry.

[13]  S. Danyluk,et al.  Conformational properties of adenylyl-3' leads to 5'-adenosine in aqueous solution. , 1976, Biochemistry.

[14]  R. Gallo,et al.  Comparative inhibition of purified DNA polymerases from murine leukemia virus and human lymphocytes by 1-beta-D-arabinofuranosylcytosine 5'-triphosphate. , 1974, Cancer research.

[15]  K. Miura,et al.  Nucleosides and nucleotides. VI. Preparation of diribonucleoside monophosphates containing 4-thiouridine. , 1973, Journal of biochemistry.

[16]  M. P. Schweizer,et al.  Studies of the conformation and interaction in dinucleoside mono- and diphosphates by proton magnetic resonance. , 1969, Biochemistry.

[17]  W. Wechter Nucleic acids. I. The synthesis of nucleotides and dinucleoside phosphates containing ara-cytidine. , 1967, Journal of medicinal chemistry.