Gold Nanorods Mediate Tumor Cell Death by Compromising Membrane Integrity

Light-activated therapies can be used to eradicate diseased cells and tissues in a noninvasive manner. Much attention has been focused on the emerging potential of photothermolysis (also referred to as optical hyperthermia), which involves the conversion of absorbed light into heat via nonradiative mechanisms. Photoactivated effects can be localized and intensified by employing exogenous agents with large absorption cross sections, confining damage to areas of interest with minimal collateral effects.[1] In particular, targeted photothermolysis may be most effective when mediated by photothermal agents that absorb strongly at near infrared (NIR) frequencies, to enable deeper penetration into biological tissues.[2]

[1]  A. Vogel,et al.  Mechanisms of femtosecond laser nanosurgery of cells and tissues , 2005 .

[2]  Gereon Hüttmann,et al.  Elevation of plasma membrane permeability by laser irradiation of selectively bound nanoparticles. , 2005, Journal of biomedical optics.

[3]  Ji-Xin Cheng,et al.  Controlling the cellular uptake of gold nanorods. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[4]  Thomas Kelly,et al.  Synergistic enhancement of selective nanophotothermolysis with gold nanoclusters: Potential for cancer therapy , 2005, Lasers in surgery and medicine.

[5]  Cheng-Dah Chen,et al.  Highly efficient, wavelength-tunable, gold nanoparticle based optothermal nanoconvertors. , 2005, The journal of physical chemistry. B.

[6]  Xunbin Wei,et al.  Selective cell targeting with light-absorbing microparticles and nanoparticles. , 2003, Biophysical journal.

[7]  A. Plech,et al.  Cavitation dynamics on the nanoscale , 2005 .

[8]  A. Wei,et al.  Dithiocarbamate assembly on gold. , 2005, Journal of the American Chemical Society.

[9]  Hiromi Okamoto,et al.  Near-field two-photon-induced photoluminescence from single gold nanorods and imaging of plasmon modes. , 2005, The journal of physical chemistry. B.

[10]  Ji-Xin Cheng,et al.  Hyperthermic effects of gold nanorods on tumor cells. , 2007, Nanomedicine.

[11]  J. West,et al.  Immunotargeted nanoshells for integrated cancer imaging and therapy. , 2005, Nano letters.

[12]  Iris Riemann,et al.  Intratissue surgery with 80 MHz nanojoule femtosecond laser pulses in the near infrared. , 2002, Optics express.

[13]  Catherine J Murphy,et al.  Seeded high yield synthesis of short Au nanorods in aqueous solution. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[14]  A. Wyllie,et al.  Cell death: the significance of apoptosis. , 1980, International review of cytology.

[15]  Charles P. Lin,et al.  Selective cell killing by microparticle absorption of pulsed laser radiation , 1999 .

[16]  Andrew McCaskie,et al.  Nanomedicine , 2005, BMJ.

[17]  P. Wust,et al.  Hyperthermia in combined treatment of cancer. , 2002, The Lancet Oncology.

[18]  R. Stafford,et al.  Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Vladimir P. Zharov,et al.  Microbubbles-overlapping mode for laser killing of cancer cells with absorbing nanoparticle clusters , 2005 .

[20]  M. El-Sayed,et al.  Shape and size dependence of radiative, non-radiative and photothermal properties of gold nanocrystals , 2000 .

[21]  P. Jain,et al.  Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. , 2006, The journal of physical chemistry. B.

[22]  T. Niidome,et al.  Gold Nanorod-sensitized Cell Death: Microscopic Observation of Single Living Cells Irradiated by Pulsed Near-infrared Laser Light in the Presence of Gold Nanorods , 2006 .

[23]  Paul Mulvaney,et al.  Drastic reduction of plasmon damping in gold nanorods. , 2002 .

[24]  M. Estacion,et al.  Maitotoxin-induced membrane blebbing and cell death in bovine aortic endothelial cells , 2001, BMC Physiology.

[25]  Ekaterina Lukianova,et al.  Selective laser nano‐thermolysis of human leukemia cells with microbubbles generated around clusters of gold nanoparticles , 2006, Lasers in surgery and medicine.

[26]  B. Trump,et al.  HgCl2-induced alteration of actin filaments in cultured primary rat proximal tubule epithelial cells labelled with fluorescein phalloidin , 1991, Cell Biology and Toxicology.

[27]  Paul Mulvaney,et al.  Electric‐Field‐Directed Growth of Gold Nanorods in Aqueous Surfactant Solutions , 2004 .

[28]  C. Murphy,et al.  Quantitation of metal content in the silver-assisted growth of gold nanorods. , 2006, The journal of physical chemistry. B.

[29]  D. P. O'Neal,et al.  Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. , 2004, Cancer letters.

[30]  W. Denk,et al.  Deep tissue two-photon microscopy , 2005, Nature Methods.

[31]  Xiaohua Huang,et al.  Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. , 2006, Journal of the American Chemical Society.

[32]  Philip S Low,et al.  Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. , 2004, Advanced drug delivery reviews.

[33]  Daniel A. Zweifel,et al.  Sulfide-Arrested Growth of Gold Nanorods. , 2005, Chemistry of materials : a publication of the American Chemical Society.

[34]  P. Low,et al.  Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis. , 1994, The Journal of biological chemistry.

[35]  G. Wiederrecht,et al.  Surface plasmon characteristics of tunable photoluminescence in single gold nanorods. , 2005, Physical review letters.

[36]  R.R. Anderson,et al.  Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. , 1983, Science.

[37]  B. Trump,et al.  Calcium‐mediated cell injury and cell death , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[38]  Philip S Low,et al.  In vitro and in vivo two-photon luminescence imaging of single gold nanorods. , 2005, Proceedings of the National Academy of Sciences of the United States of America.