Human exposure to toxic metals via contaminated dust: Bio-accumulation trends and their potential risk estimation.

We assessed the levels of potentially toxic trace metals, Zinc (Zn), Lead (Pb), Manganese (Mn), Copper (Cu), Nickel (Ni), Chromium (Cr), Cobalt (Co), and Cadmium (Cd), in dust, hair, nail and serum, sampled in rural, urban and industrial areas of Punjab, Pakistan. Trace metals occurrence in all samples, in descending order, was: Zn, Pb, Mn, Cu, Cr, Ni, Co, Cd. The samples from the urban areas showed significantly higher concentration of toxic trace metals (Zn, Ni, Cr, Co, Mn, and Cd) than those from industrial (which conversely had higher levels of Pb and Cu), and than samples from rural areas. Bioaccumulation patterns showed that dust exposure is one of the major routes into human body for Cd, Pb, Co, Mn and Cr, while the burden of Zn, Cu, and Ni can be more linked to dietary sources. The concentrations of trace metals in the samples from Punjab were comparable and/or higher than those reported worldwide. In many cases, the levels of Zn, Cr, Pb, Ni and Cd in hair and nail were beyond the ATSDR threshold guideline values that may cause some serious health effects. Hazard Index (HI) calculated for trace metal concentrations in the human population of Punjab points particularly to health risks from Cd (for children in urban and industrial areas) and from Pb (for all sub-groups).

[1]  D. Weisenburger,et al.  Use of hair coloring products and the risk of lymphoma, multiple myeloma, and chronic lymphocytic leukemia. , 1992, American journal of public health.

[2]  R. Sutherland,et al.  Multi-element analysis of road-deposited sediment in an urban drainage basin, Honolulu, Hawaii. , 2000, Environmental pollution.

[3]  R. Hamidi,et al.  Seed quality and micronutrient contents and translocations in rapeseed (Brassica napus L.) as affected by nitrogen and zinc fertilizers , 2014 .

[4]  J. M. Christensen,et al.  Trace element reference values in tissues from inhabitants of the European Community. V. Review of trace elements in blood, serum and urine and critical evaluation of reference values for the Danish population. , 1994, The Science of the total environment.

[5]  M. Tufail,et al.  Road dust pollution of Cd, Cu, Ni, Pb and Zn along Islamabad Expressway, Pakistan , 2009 .

[6]  R. N. Malik,et al.  Metal contamination of surface soils of industrial city Sialkot, Pakistan: a multivariate and GIS approach , 2010, Environmental geochemistry and health.

[7]  L. Duran,et al.  Serum Levels of Trace Elements and Heavy Metals in Patients with Acute Hemorrhagic Stroke , 2013, The Journal of Membrane Biology.

[8]  I. Yoruk,et al.  Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease , 2011, International journal of medical sciences.

[9]  F Cibella,et al.  Concentration and reference interval of trace elements in human hair from students living in Palermo, Sicily (Italy). , 2011, Environmental toxicology and pharmacology.

[10]  M. Wilhelm,et al.  Concentrations of lead in blood, hair and saliva of German children living in three different areas of traffic density. , 2002, The Science of the total environment.

[11]  F. Barbosa,et al.  Background Values for Essential and Toxic Elements in Children’s Nails and Correlation with Hair Levels , 2011, Biological Trace Element Research.

[12]  T. Simons.  Cellular interactions between lead and calcium. , 1986, British medical bulletin.

[13]  T. Kazi,et al.  Evaluation of Toxic Metals in Blood and Urine Samples of Chronic Renal Failure Patients, before and after Dialysis , 2008, Renal failure.

[14]  E. Miguel,et al.  Origin and patterns of distribution of trace elements in street dust: Unleaded petrol and urban lead , 1997 .

[15]  Markus J. Tamás,et al.  Heavy Metals and Metalloids As a Cause for Protein Misfolding and Aggregation , 2014, Biomolecules.

[16]  Lbg,et al.  Human exposure to soil contamination: a qualitative and quantitative analysis towards proposals for human toxicological intervention values (partly revised edition) , 1994 .

[17]  R. Norman,et al.  Health consequences of exposure to e-waste: a systematic review. , 2013, The Lancet. Global health.

[18]  D. Meza-Figueroa,et al.  Heavy metal distribution in dust from elementary schools in Hermosillo, Sonora, México , 2007 .

[19]  R. N. Malik,et al.  Organohalogenated contaminants (OHCs) in the serum and hair of pet cats and dogs: biosentinels of indoor pollution. , 2013, The Science of the total environment.

[20]  J. Murungi,et al.  Use of human nails as bio-indicators of heavy metals environmental exposure among school age children in Kenya. , 2008, The Science of the total environment.

[21]  R. Ribeiro,et al.  Scalp hair analysis as a tool in assessing human exposure to heavy metals (S. Domingos mine, Portugal). , 2004, The Science of the total environment.

[22]  Marta Esteban,et al.  Non-invasive matrices in human biomonitoring: a review. , 2009, Environment international.

[23]  S. Morais,et al.  Heavy Metals and Human Health , 2012 .

[24]  Riffat Naseem Malik,et al.  Spatio-temporal variations in water quality of Nullah Aik-tributary of the river Chenab, Pakistan , 2008, Environmental monitoring and assessment.

[25]  I. Michalak,et al.  Effects of Local Industry on Heavy Metals Content in Human Hair , 2012 .

[26]  X. Querol,et al.  Sources and variability of inhalable road dust particles in three European cities , 2011 .

[27]  Said Muhammad,et al.  Health risk assessment of heavy metals and their source apportionment in drinking water of Kohistan region, northern Pakistan , 2011 .

[28]  Perihan Binnur Kurt-Karakus,et al.  Determination of heavy metals in indoor dust from Istanbul, Turkey: estimation of the health risk. , 2012, Environment international.

[29]  Syarif Husin Lubis,et al.  Study of heavy metal levels in nails and hairs among vegetable farmers in Malaysia , 2013 .

[30]  L. Sörme,et al.  Sources of heavy metals in urban wastewater in Stockholm. , 2002, The Science of the total environment.

[31]  Li Wang,et al.  Potentially toxic metal contamination of urban soils and roadside dust in Shanghai, China. , 2008, Environmental pollution.

[32]  Na Zheng,et al.  Health risk assessment of heavy metal exposure to street dust in the zinc smelting district, Northeast of China. , 2010, The Science of the total environment.

[33]  Jichun Wu,et al.  Bioaccessibility and health risk of arsenic and heavy metals (Cd, Co, Cr, Cu, Ni, Pb, Zn and Mn) in TSP and PM2.5 in Nanjing, China , 2012 .

[34]  K. Shin,et al.  Assessment of reference values for hair minerals of Korean preschool children , 2007, Biological Trace Element Research.

[35]  J. Entwistle,et al.  Estimation of daily intake of potentially toxic elements from urban street dust and the role of oral bioaccessibility testing. , 2012, Chemosphere.

[36]  K. S. Subramanian,et al.  A multi-element profile of housedust in relation to exterior dust and soils in the city of Ottawa, Canada. , 2001, The Science of the total environment.

[37]  D. Ritchie.  Handbook of copper compounds and applications , 1998 .

[38]  Nour Zahi Gammoh,et al.  Zinc and the immune system , 2000, Proceedings of the Nutrition Society.

[39]  M. Saleh.  Lead and Cadmium assay in Serum and Semen of Infertile Men attending Andrology clinic in Assiut University Hospital (Rural versus Urban) , 2013 .

[40]  U. Farooq,et al.  Status of heavy metal residues in fish species of Pakistan. , 2014, Reviews of environmental contamination and toxicology.

[41]  A Peña-Fernández,et al.  Establishing the importance of human health risk assessment for metals and metalloids in urban environments. , 2014, Environment international.

[42]  T Norseth,et al.  Congenital defects, abortion and other health effects in nickel refinery workers. , 1994, The Science of the total environment.

[43]  R. N. Malik,et al.  Status of Organochlorine Contaminants in the Different Environmental Compartments of Pakistan: A Review on Occurrence and Levels , 2012, Bulletin of Environmental Contamination and Toxicology.

[44]  R. Mehra,et al.  Elements in scalp hair and nails indicating metal body burden in polluted environment , 2005 .

[45]  B. Ismail,et al.  Bioaccumulation of Heavy Metals in Vegetables from Selected Agricultural Areas , 2005, Bulletin of environmental contamination and toxicology.

[46]  R. Fry,et al.  Toxic metal levels in children residing in a smelting craft village in Vietnam: a pilot biomonitoring study , 2014, BMC Public Health.

[47]  M. Arias-Estévez,et al.  Copper distribution and acid‐base mobilization in vineyard soils and sediments from Galicia (NW Spain) , 2008 .

[48]  M. Ubaidullah,et al.  ASSESSMENT OF HEAVY METALS IN SEDIMENTS OF THE RIVER RAVI, PAKISTAN , 2009 .

[49]  P Apostoli,et al.  Trace element reference values in tissues from inhabitants of the European community. I. A study of 46 elements in urine, blood and serum of Italian subjects. , 1990, The Science of the total environment.

[50]  Heqing Shen,et al.  Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility , 2015, Environmental Geochemistry and Health.

[51]  P. A. Warren,et al.  Focused medical surveillance: a search for subclinical movement disorders in a cohort of U.S. workers exposed to low levels of manganese dust. , 1999, Neurotoxicology.

[52]  Guibin Jiang,et al.  Use of scalp hair as indicator of human exposure to heavy metals in an electronic waste recycling area. , 2009, Environmental pollution.

[53]  N. Ali,et al.  Avian feathers as a non-destructive bio-monitoring tool of trace metals signatures: a case study from severely contaminated areas. , 2015, Chemosphere.

[54]  M. Rashed,et al.  Heavy Metals in Fingernails and Scalp Hair of Children, Adults and Workers from Environmentally Exposed Areas at Aswan, Egypt , 2007 .

[55]  K. Mahaffey.  Nutrition and lead: strategies for public health. , 1995, Environmental health perspectives.

[56]  Shafiqur Rehman,et al.  Soil and vegetables enrichment with heavy metals from geological sources in Gilgit, northern Pakistan. , 2010, Ecotoxicology and environmental safety.

[57]  F. I. Abdulrahman,et al.  Levels of Heavy Metals in Human Hair and Nail Samples from Maiduguri Metropolis, Borno State, Nigeria , 2012 .

[58]  M. Anees,et al.  Heavy Metals Accumulation and Their Toxic Effects: Review , 2013 .

[59]  B. Eskenazi,et al.  Blood and Hair Manganese Concentrations in Pregnant Women from the Infants’ Environmental Health Study (ISA) in Costa Rica , 2014, Environmental science & technology.

[60]  Gang Wu,et al.  A critical review on the bio-removal of hazardous heavy metals from contaminated soils: issues, progress, eco-environmental concerns and opportunities. , 2010, Journal of hazardous materials.

[61]  Mats Gustafsson,et al.  Urban air quality: the challenge of traffic non-exhaust emissions. , 2014, Journal of hazardous materials.

[62]  J. Yoshinaga,et al.  Lead and other elements in house dust of Japanese residences--source of lead and health risks due to metal exposure. , 2014, Environmental pollution.

[63]  M. Saiki,et al.  Hair analysis: applications in the biomedical and environmental sciences , 2014 .

[64]  A Ordóñez,et al.  A comparative study of heavy metal concentration and distribution in deposited street dusts in a large and a small urban area: Birmingham and Coventry, West Midlands, UK. , 2003, Environment international.

[65]  R. Gibson,et al.  A growth-limiting, mild zinc-deficiency syndrome in some southern Ontario boys with low height percentiles. , 1989, The American journal of clinical nutrition.

[66]  D. Chakraborti,et al.  Arsenic and other elements in hair, nails, and skin-scales of arsenic victims in West Bengal, India. , 2004, The Science of the total environment.