Acid‐Stabilized Plasmin as a Novel Direct‐Acting Thrombolytic

[1]  R. Shlansky-Goldberg,et al.  PS124. Plasmin (Human) TAL-05-00018 Demonstrates a Good Safety Profile in Patients with Acute Peripheral Arterial Occlusion , 2011 .

[2]  R. Jahan,et al.  Thrombolysis With Plasmin: Implications for Stroke Treatment , 2010, Stroke.

[3]  R. Shlansky-Goldberg,et al.  A first‐in‐human phase I trial of locally delivered human plasmin for hemodialysis graft occlusion , 2008, Journal of thrombosis and haemostasis : JTH.

[4]  H. Vinters,et al.  Middle Cerebral Artery Occlusion in the Rabbit Using Selective Angiography: Application for Assessment of Thrombolysis , 2008, Stroke.

[5]  R. Shlansky-Goldberg.  Phase 1 study of human plasma-derived plasmin (TAL-05-00018) in hemodialysis graft occlusion. , 2008, Thrombosis research.

[6]  A. Comerota.  Development of catheter-directed intrathrombus thrombolysis with plasmin for the treatment of acute lower extremity arterial occlusion. , 2008, Thrombosis research.

[7]  N. Olson,et al.  Cross-species pharmacologic evaluation of plasmin as a direct-acting thrombolytic agent: ex vivo evaluation for large animal model development. , 2005, Journal of vascular and interventional radiology : JVIR.

[8]  A. Thie,et al.  Lys-plasminogen as an adjunct to local intra-arterial fibrinolysis for carotid territory stroke: laboratory and clinical findings , 1996, Neuroradiology.

[9]  V. Novokhatny,et al.  Thrombolytic potency of acid‐stabilized plasmin: superiority over tissue‐type plasminogen activator in an in vitro model of catheter‐assisted thrombolysis , 2003, Journal of thrombosis and haemostasis : JTH.

[10]  V. Marder,et al.  Distinct dose-dependent effects of plasmin and TPA on coagulation and hemorrhage. , 2003, Blood.

[11]  V. Marder,et al.  Plasmin Induces Local Thrombolysis without Causing Hemorrhage: A Comparison with Tissue Plasminogen Activator in the Rabbit , 2001, Thrombosis and Haemostasis.

[12]  P. Higgins,et al.  Targeted inhibition of wound-induced PAI-1 expression alters migration and differentiation in human epidermal keratinocytes. , 2000, Experimental cell research.

[13]  A. Singer,et al.  Cutaneous wound healing. , 1999, The New England journal of medicine.

[14]  P. Carmeliet,et al.  Gene Targeting and Gene Transfer Studies of the Biological Role of the Plasminogen/Plasmin System , 1995, Thrombosis and Haemostasis.

[15]  J. Mehta,et al.  Recombinant lys-plasminogen, but not glu-plasminogen, improves recombinant tissue-type plasminogen activator-induced coronary thrombolysis in dogs. , 1995, Journal of the American College of Cardiology.

[16]  C. Ponting,et al.  Plasminogen: a structural review. , 1992, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[17]  D. Rijken,et al.  The Amount of Plasminogen, Tissue-Type Plasminogen Activator and Plasminogen Activator Inhibitor Type 1 in Human Thrombi and the Relation to IVVO-TNO Lysibility , 1992, Thrombosis and Haemostasis.

[18]  J. Henkin,et al.  The plasminogen-plasmin system. , 1991, Progress in cardiovascular diseases.

[19]  H. Wu,et al.  Interaction of plasminogen and fibrin in plasminogen activation. , 1990, The Journal of biological chemistry.

[20]  S. L. Gonias,et al.  Regulation of plasmin, miniplasmin, and streptokinase-plasmin complex by α2-antiplasmin, α2-macroglobulin, and antithrombin III in the presence of heparin1 , 1990 .

[21]  Y. Takada,et al.  The mechanisms of the activation of plasminogen by streptokinase and urokinase. , 1990, Advances in experimental medicine and biology.

[22]  D. Keber,et al.  Effect of Retraction on the Lysis of Human Clots with Fibrin Specific and Non-Fibrin Specific Plasminogen Activators , 1989, Thrombosis and Haemostasis.

[23]  D. Strickland,et al.  Characterization of the reaction of plasmin with alpha 2-macroglobulin: effect of antifibrinolytic agents. , 1987, Biochemistry.

[24]  P. McKee,et al.  The binding of human plasminogen to fibrin and fibrinogen. , 1983, The Journal of biological chemistry.

[25]  S. Thorsen,et al.  Secondary-site binding of Glu-plasmin, Lys-plasmin and miniplasmin to fibrin. , 1981, The Biochemical journal.

[26]  P. Lerch,et al.  Localization of individual lysine-binding regions in human plasminogen and investigations on their complex-forming properties. , 1980, European journal of biochemistry.

[27]  B. Wiman,et al.  On the specific interaction between the lysine-binding sites in plasmin and complementary sites in alpha2-antiplasmin and in fibrinogen. , 1979, Biochimica et biophysica acta.

[28]  B. Wiman,et al.  On the kinetics of the reaction between human antiplasmin and plasmin. , 1978, European journal of biochemistry.

[29]  B. Wiman,et al.  The specific interaction between plasminogen and fibrin. A physiological role of the lysine binding site in plasminogen. , 1977, Thrombosis research.

[30]  N. Aoki,et al.  Isolation and characterization of alpha2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis. , 1976, The Journal of biological chemistry.

[31]  D. Collen.  Identification and some properties of a new fast-reacting plasmin inhibitor in human plasma. , 1976, European journal of biochemistry.

[32]  B. Violand,et al.  Mechanism of the urokinase-catalyzed activation of human plasminogen. , 1976, The Journal of biological chemistry.

[33]  A. Amery,et al.  ENZYMATIC CLOT DISSOLUTION IN MAN: A NEW THERAPEUTIC APPROACH. , 1964, Acta clinica Belgica.

[34]  J. F. Johnson,et al.  Treatment of cerebrovascular thrombosis with fibrinolysin. Preliminary report. , 1960, The American journal of cardiology.

[35]  B. Carroll,et al.  Treatment of thrombophlebitis with a fibrinolytic agent, with special references to side effects. , 1960, The American journal of cardiology.

[36]  E. Cliffton.  Review of clinical experience with clotlysing agents. , 1960, The American journal of cardiology.

[37]  K. Moser.  Effects of Intravenous Administration of Fibrinolysin (Plasmin) in Man , 1959, Circulation.

[38]  A. Fletcher,et al.  The mechanism of clot dissolution by plasmin. , 1959, The Journal of clinical investigation.

[39]  E. Cliffton.  THE USE OF PLASMIN IN THE TREATMENT OF INTRAVASCULAR THROMBOSES † † , 1958, Journal of the American Geriatrics Society.

[40]  N. Back,et al.  CLINICAL AND EXPERIMENTAL STUDIES ON FIBRINOLYTIC ENZYMES , 1957, Annals of the New York Academy of Sciences.

[41]  C. Macleod,et al.  A PROTEOLYTIC ENZYME OF SERUM: CHARACTERIZATION, ACTIVATION, AND REACTION WITH INHIBITORS , 1945, The Journal of general physiology.

[42]  L. R. Christensen.  STREPTOCOCCAL FIBRINOLYSIS: A PROTEOLYTIC REACTION DUE TO A SERUM ENZYME ACTIVATED BY STREPTOCOCCAL FIBRINOLYSIN , 1945, The Journal of general physiology.

[43]  M. H. Kaplan,et al.  Nature and Role of the Lytic Factor in Hemolytic Streptococcal Fibrinolysis.∗ , 1944 .

[44]  W. Tillett,et al.  THE FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCI , 1933, The Journal of experimental medicine.