A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing.
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[1] Stefan Rose-John,et al. IL-6 biology: implications for clinical targeting in rheumatic disease , 2014, Nature Reviews Rheumatology.
[2] J. Scheller,et al. Recombinant p35 from Bacteria Can Form Interleukin (IL-)12, but Not IL-35 , 2014, PloS one.
[3] J. Scheller,et al. Alternative Intronic Polyadenylation Generates the Interleukin-6 Trans-signaling Inhibitor sgp130-E10* , 2014, The Journal of Biological Chemistry.
[4] J. Scheller,et al. Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities. , 2014, Seminars in immunology.
[5] J. Scheller,et al. Interleukin-6 and interleukin-11: same same but different , 2013, Biological chemistry.
[6] J. Scheller,et al. Minimal Interleukin 6 (IL-6) Receptor Stalk Composition for IL-6 Receptor Shedding and IL-6 Classic Signaling , 2013, The Journal of Biological Chemistry.
[7] S. Rose-John. IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6 , 2012, International journal of biological sciences.
[8] H. Hermanns,et al. Plasticity and cross-talk of interleukin 6-type cytokines. , 2012, Cytokine & growth factor reviews.
[9] S. Rose-John,et al. Hitting a complex target: an update on interleukin-6 trans-signalling , 2012, Expert opinion on therapeutic targets.
[10] J. Scheller,et al. Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor* , 2011, The Journal of Biological Chemistry.
[11] J. Scheller,et al. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. , 2011, The Journal of clinical investigation.
[12] J. Scheller,et al. The pro- and anti-inflammatory properties of the cytokine interleukin-6. , 2011, Biochimica et biophysica acta.
[13] J. Scheller,et al. Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding* , 2011, The Journal of Biological Chemistry.
[14] C. Fielding,et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. , 2006, Arthritis and rheumatism.
[15] Stefan Rose-John,et al. Dynamics of the gp130 cytokine complex: A model for assembly on the cellular membrane , 2005, Protein science : a publication of the Protein Society.
[16] C. Hölscher. The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases , 2004, Medical Microbiology and Immunology.
[17] M. Neurath,et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. , 2001, European journal of biochemistry.
[18] K. Nakao,et al. Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. , 2000, The Journal of clinical investigation.
[19] S. Rose-John,et al. IL-6 Type Cytokine Receptor Complexes: Hexamer, Tetramer or Both? , 1999, Biological chemistry.
[20] B. Klein,et al. Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin‐6 signal transducer gp130 1 , 1997, FEBS letters.
[21] S. Rose-John,et al. A bioactive designer cytokine for human hematopoietic progenitor cell expansion , 1997, Nature Biotechnology.
[22] T. Kishimoto,et al. Gp130 and the interleukin-6 family of cytokines. , 1997, Annual review of immunology.
[23] Stephen K. Smith,et al. Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos. , 1995, Biology of reproduction.
[24] S. Ziegler,et al. Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[25] G. Yancopoulos,et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. , 1993, Blood.
[26] P. Heinrich,et al. Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding. , 1993, The Journal of biological chemistry.