论文信息 - Tss (Tail-short Shionogi), a new short tail mutation found in the BALB/cMs strain, maps quite closely to the Tail-short (Ts) locus on mouse chromosome 11.

Tss (Tail-short Shionogi), a new short tail mutation found in the BALB/cMs strain, maps quite closely to the Tail-short (Ts) locus on mouse chromosome 11.

A spontaneous morphological mutation characterized by a short and kinky tail (Tail-short Shionogi: Tss) was observed in a BALB/cMs mouse breeding colony. The inheritance mode of the Tss mutation is semi-dominant, and homozygotes (Tss/Tss) are probably embryonic lethal. The viability of the Tss/+ heterozygotes appear to be influenced by the mating partner: 47.1% of the (BALB/cMs-Tss/+ x C57BL/6J)F1 embryos were the mutant phenotype, whereas there were no (BALB/cMs-Tss/+ x A/J)F1 embryos with the mutant phenotype. The Tss locus was mapped by linkage analysis between microsatellite markers D11Mit128 and D11Mit256 on mouse Chromosome 11. These results suggest that the Tss mutation is a new allele on the Tail-short (Ts) locus.

T. Hirasawa | S. Makino | K. Tsukahara

[1] S. Makino,et al. The FLS mouse: a new inbred strain with spontaneous fatty liver. , 1999, Laboratory animal science.

[2] M. Morishima,et al. Dominant lethality of the mouse skeletal mutation tail-short (Ts) is determined by the Ts allele from mating partners. , 1998, Genomics.

[3] T. Hirasawa,et al. Genetic typing of the mouse and rat nude mutations by PCR and restriction enzyme analysis. , 1998, Experimental animals.

[4] S. Makino,et al. Genetic typing of the mouse ob mutation by PCR and restriction enzyme analysis. , 1997, Experimental animals.

[5] Eric S. Lander,et al. A genetic map of the mouse with 4,006 simple sequence length polymorphisms , 1994, Nature Genetics.

[6] H. Paterson. In vivo and in vitro studies on the early embryonic lethal tail-short (Ts) in the mouse. , 1980, The Journal of experimental zoology.

[7] M. Deol. Genetical studies on the skeleton of the mouse - XXVIII. Tail-short , 1961, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[8] W. Morgan. A new tail-short mutation in the mouse whose lethal effects are conditioned by the residual genotypes. , 1950, The Journal of heredity.