A Pilot Study of Urokinase Therapy in Cerebral Infarction

SUMMARY Thirty-one patients with acute cerebral infarction were treated with the thrombolytic agent urokinase for either a single or a double infusion period, each of ten hours. The effects of urokinase therapy administered at dosage rates of 1,200, 1,500 or 1,700 CTA urokinase units per pound of body weight per hour were followed by serial blood coagulation and other biochemical studies. In the dosage used, urokinase produced a prompt sustained increase, 20-fold to 40-fold, of plasma thrombolytic activity with relatively minor disturbance of the blood coagulation system. Nevertheless, hemorrhagic complications occurred in several patients and distinctly favorable therapeutic effects were not observed.

[1]  M. Raichle,et al.  Blood Coagulation and Plasma Fibrinolytic Enzyme System Pathophysiology in Stroke , 1976, Stroke.

[2]  Barry A. Siegel,et al.  Brain Scanning in Cerebral Vascular Disease: A Reappraisal , 1975, Stroke.

[3]  A. Fletcher,et al.  D – Thrombolysis and Thrombolytic Agents , 1974 .

[4]  E. Murphy,et al.  Analysis of gel exclusion chromatographic data by chromatographic plate theory analysis: Application to plasma fibrinogen chromatography , 1973 .

[5]  The urokinase pulmonary embolism trial. A national cooperative study. , 1973, Circulation.

[6]  A. M. Benis.  A new simple low-shear capillary viscometer for blood. , 1968, Biorheology.

[7]  J. Heremans,et al.  Immunochemical quantitation of antigens by single radial immunodiffusion. , 1965, Immunochemistry.

[8]  D. P. Cooney.  BLOOD COAGULATION, HEMORRHAGE AND THROMBOSIS: Methods of Study , 1965 .

[9]  A. Fletcher,et al.  THE ASSAY OF UROKINASE PREPARATIONS FOR CONTAMINATION WITH THROMBOPLASTIC MOIETIES. , 1965, The Journal of laboratory and clinical medicine.

[10]  A. Fletcher,et al.  THE DEVELOPMENT OF UROKINASE AS A THROMBOLYTIC AGENT. MAINTENANCE OF A SUSTAINED THROMBOLYTIC STATE IN MAN BY ITS INTRAVENOUS INFUSION. , 1965, The Journal of laboratory and clinical medicine.

[11]  A. Lesuk,et al.  Crystalline Human Urokinase: Some Properties , 1965, Science.

[12]  S. Sherry,et al.  A Comparison of the Fibrinolytic and Fibrinogenolytic Effects of Plasminogen Activators and Proteolytic Enzymes in Plasma , 1961, Thrombosis and Haemostasis.

[13]  N. Neff.  Current status of thrombolytic agents. , 1959, American journal of pharmacy and the sciences supporting public health.