Diffusion tensor MR imaging of the cervical spinal cord in patients with multiple sclerosis

Our purpose was to evaluate the ability of diffusion tensor imaging (DTI) to characterize cervical spinal cord white matter (WM) in patients with multiple sclerosis (MS). DTI were obtained in 21 MS patients and 21 control subjects (CS). Regions of interest (ROIs) were placed at C2/3, C3/4, and C4/5 within the right, left, and dorsal (WM) to calculate fractional anisotropy (FA) and the apparent diffusion coefficient (ADC). Measurements in plaques and normal-appearing white matter (NAWM) of MS patients were compared with mean FA and ADC of WM in CS. FA was significantly lower in all regions in MS patients than in CS. ADC was significantly higher in all regions in MS patients than in CS except for in the dorsal WM at C2/3 and the bilateral WM at C4/5. The mean FA was 0.441 for plaques and 0.542 for NAWM, as compared with 0.739 in CS. The mean ADC was 0.810 × 10−3 mm2/s for plaques and 0.722 × 10−3 mm2/s for NAWM, as compared with 0.640 ×10−3 mm2/s for CS. FA and ADC showed significant differences between plaques, NAWM and control WM(P < 0.01).

[1]  D. Prayer,et al.  Spinal cord lesions in patients with multiple sclerosis: comparison of MR pulse sequences. , 1996, AJNR. American journal of neuroradiology.

[2]  K J Klose,et al.  High-resolution diffusion-weighted MR of fresh and fixed cat spinal cords: evaluation of diffusion coefficients and anisotropy. , 1997, AJNR. American journal of neuroradiology.

[3]  P. Scheltens,et al.  MR of the spinal cord in multiple sclerosis: relation to clinical subtype and disability. , 1997, AJNR. American journal of neuroradiology.

[4]  G. Barker,et al.  Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis , 1999, Neurology.

[5]  T. Ptak,et al.  Investigation of apparent diffusion coefficient and diffusion tensor anisotrophy in acute and chronic multiple sclerosis lesions. , 1999, AJNR. American journal of neuroradiology.

[6]  C. Holder,et al.  Diffusion-weighted MR imaging of the normal human spinal cord in vivo. , 2000, AJNR. American journal of neuroradiology.

[7]  R Stollberger,et al.  Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis , 2000, Magnetic resonance in medicine.

[8]  David H. Miller,et al.  Diffusion imaging of the spinal cord in vivo: Estimation of the principal diffusivities and application to multiple sclerosis , 2000, Magnetic resonance in medicine.

[9]  James M Provenzale,et al.  Multiple sclerosis: diffusion tensor MR imaging for evaluation of normal-appearing white matter. , 2002, Radiology.

[10]  F Barkhof,et al.  Axonal damage in the spinal cord of MS patients occurs largely independent of T2 MRI lesions , 2002, Neurology.

[11]  Massimo Filippi,et al.  The use of quantitative magnetic-resonance-based techniques to monitor the evolution of multiple sclerosis , 2003, The Lancet Neurology.

[12]  R. Ordidge,et al.  High field MRI correlates of myelin content and axonal density in multiple sclerosis , 2003, Journal of Neurology.

[13]  F. Regli,et al.  Magnetic resonance imaging in patients with multiple sclerosis and spinal cord involvement: 28 cases , 2004, Journal of Neurology.

[14]  F. Barkhof,et al.  The spinal cord in multiple sclerosis: relationship of high-spatial-resolution quantitative MR imaging findings to histopathologic results. , 2004, Radiology.

[15]  James M Provenzale,et al.  Redefinition of multiple sclerosis plaque size using diffusion tensor MRI. , 2004, AJR. American journal of roentgenology.

[16]  J. Provenzale,et al.  Determination of multiple sclerosis plaque size with diffusion-tensor MR Imaging: comparison study with healthy volunteers. , 2005, Radiology.

[17]  M. Oudkerk,et al.  Analysis of the human brain in primary progressive multiple sclerosis with mapping of the spatial distributions using 1H MR spectroscopy and diffusion tensor imaging , 2005, European Radiology.

[18]  Marco Rovaris,et al.  Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients , 2005, NeuroImage.

[19]  G. Comi,et al.  Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRI , 2005, Neurology.

[20]  M. Oudkerk,et al.  Relationships between brain water content and diffusion tensor imaging parameters (apparent diffusion coefficient and fractional anisotropy) in multiple sclerosis , 2006, European Radiology.

[21]  G. Johnson,et al.  Diffusion tensor imaging in multiple sclerosis: assessment of regional differences in the axial plane within normal-appearing cervical spinal cord. , 2006, AJNR. American journal of neuroradiology.