Scientists Share Nuclear Secrets at Jekyll Island

Nuclear transport pathways use soluble receptors to mediate the translocation of protein and cargo through the nuclear pore complex (NPC). In October 2005, investigators from around the globe braved the threat of hurricane Wilma and presented their latest findings at the Nucleocytoplasmic Transport Meeting at Jekyll Island, GA, USA. The meeting was organized by Drs Maureen Powers, Chuck Cole, and Douglass Forbes. Major themes within the meeting included architecture of the NPC, structural analysis of receptors, regulation of nuclear transport, models for translocation, and emerging roles for the NPC and lamina in gene expression.

[1]  B. E. Black,et al.  Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization. , 2006, Molecular endocrinology.

[2]  M. Hetzer,et al.  Pushing the envelope: structure, function, and dynamics of the nuclear periphery. , 2005, Annual review of cell and developmental biology.

[3]  A. Hopper,et al.  Retrograde movement of tRNAs from the cytoplasm to the nucleus in Saccharomyces cerevisiae. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[4]  R. Reed,et al.  TREX, SR proteins and export of mRNA. , 2005, Current opinion in cell biology.

[5]  T. Misteli Faculty Opinions recommendation of A systems analysis of importin-{alpha}-{beta} mediated nuclear protein import. , 2005 .

[6]  G. Riddick,et al.  A systems analysis of importin-α–β mediated nuclear protein import , 2005, The Journal of Cell Biology.

[7]  B. Paschal,et al.  Mechanisms of Receptor‐Mediated Nuclear Import and Nuclear Export , 2005, Traffic.

[8]  Daniel Zenklusen,et al.  Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export , 2005, The EMBO journal.

[9]  Yoshiyuki Matsuura,et al.  Structural basis for the assembly of a nuclear export complex , 2004, Nature.

[10]  S. Emr,et al.  Cytoplasmic Inositol Hexakisphosphate Production Is Sufficient for Mediating the Gle1-mRNA Export Pathway* , 2004, Journal of Biological Chemistry.

[11]  A. Harel,et al.  Importin beta: conducting a much larger cellular symphony. , 2004, Molecular cell.

[12]  L. Pemberton,et al.  Karyopherins: from nuclear-transport mediators to nuclear-function regulators. , 2004, Trends in cell biology.

[13]  D. Goldfarb,et al.  Importin α: A multipurpose nuclear-transport receptor , 2004 .

[14]  D. Goldfarb,et al.  Minimal nuclear pore complexes define FG repeat domains essential for transport , 2004, Nature Cell Biology.

[15]  D. Svergun,et al.  Conformational Variability of Nucleo-cytoplasmic Transport Factors* , 2004, Journal of Biological Chemistry.

[16]  John D. Aitchison,et al.  Cell Cycle Regulated Transport Controlled by Alterations in the Nuclear Pore Complex , 2003, Cell.

[17]  U. Kutay,et al.  Nucleocytoplasmic transport: taking an inventory , 2003, Cellular and Molecular Life Sciences CMLS.

[18]  M. Dasso,et al.  The Ran GTPase regulates kinetochore function. , 2003, Developmental cell.

[19]  G. Cingolani,et al.  Nucleocytoplasmic Transport: Navigating the Channel , 2003, Traffic.

[20]  R. Wozniak,et al.  The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint , 2002, The Journal of cell biology.

[21]  B. Chait,et al.  Proteomic analysis of the mammalian nuclear pore complex , 2002, The Journal of cell biology.

[22]  U. K. Laemmli,et al.  Chromatin Boundaries in Budding Yeast The Nuclear Pore Connection , 2002, Cell.

[23]  H. Le Hir,et al.  The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense‐mediated mRNA decay , 2001, The EMBO journal.

[24]  B. Chait,et al.  The Yeast Nuclear Pore Complex: Composition, Architecture, and Transport Mechanism , 2000 .

[25]  Peer Bork,et al.  HEAT repeats in the Huntington's disease protein , 1995, Nature Genetics.

[26]  Katherine L. Wilson,et al.  The nuclear lamina comes of age , 2005, Nature Reviews Molecular Cell Biology.

[27]  D. Goldfarb,et al.  Importin alpha: a multipurpose nuclear-transport receptor. , 2004, Trends in cell biology.

[28]  Qian Liu,et al.  Citation for Published Item: Use Policy Coupling of the Nucleus and Cytoplasm: Role of the Linc Complex , 2022 .