Febrile Seizures in Epileptic Chicks: The effects of Phenobarbital, Phenytoin and Valproate

SUMMARY: Epileptic seizures can be evoked in chicks homozygous for the epileptic seizure gene (epi, epi) by elevating their body temperature using microwave diathermy. These seizures precede and differ in motor seizure pattern from a second clonic-tonic seizure produced by hyperthermia in both epileptic and carrier (heterozygote, Epi, epi) chicks. Hyperthermia did not evoke seizures in adult epileptic chickens. Phenobarbital delayed the onset of epileptiform seizures whereas phenytoin and valproate had no effect. These data suggest that epileptic chicks may provide a suitable model for studies on febrile convulsions.

[1]  N. Kasting,et al.  Vasopressin may mediate febrile convulsions , 1981, Brain Research.

[2]  D. Johnson,et al.  Pharmacological and biochemical studies in epileptic fowl. , 1979, Federation proceedings.

[3]  R. Julien,et al.  A comparative study of the efficacy of newer antiepileptic drugs on experimentally-induced febrile convulsions , 1977, Neuropharmacology.

[4]  D. Bailey,et al.  Epileptiform seizures in domestic fowl. VI. Plasma phenobarbital concentrations and anticonvulsant activity. , 1977, Canadian journal of physiology and pharmacology.

[5]  D. Johnson,et al.  Epileptiform seizures in domestic fowl. VII. Plasma phenytoin concentrations and anticonvulsant activity. , 1977, Canadian Journal of Physiology and Pharmacology.

[6]  G. Cavazzuti.  Prevention of Febrile Convulsions with Dipropylacetate (Depakine®) , 1975, Epilepsia.

[7]  E. C. Crichlow,et al.  Epileptiform seizures in domestic fowl. II. Intermittent light stimulation and the electroencephalogram. , 1974, Canadian journal of physiology and pharmacology.

[8]  E. Ross.  Convulsive disorders in British children. , 1973, Proceedings of the Royal Society of Medicine.

[9]  K. Kastrup,et al.  Successful Prophylaxis of Febrile Convulsions with Phenobarbital , 1972, Epilepsia.

[10]  M. Lennox-Buchthal.  Febrile and Nocturnal Convulsions in Monozygotic Twins , 1971, Epilepsia.

[11]  F. Buchthal,et al.  The Ineffectiveness of Diphenylhydantoin in Preventing Febrile Convulsions in the Age of Greatest Risk, under Three Years , 1971, Epilepsia.

[12]  R. D. Crawford.  Epileptiform seizures in domestic fowl. , 1970, The Journal of heredity.

[13]  J. Yerushalmy,et al.  Studies on Convulsive Disorders in Young Children: I. Incidence of Febrile and Nonfebrile Convulsions by Age and Other Factors , 1969, Pediatric Research.

[14]  J. Eckenhoff,et al.  Physiological Pharmacology. A Comprehensive Treatise , 1964 .

[15]  W. S. Waring,et al.  ANTICONVULSANT DRUGS. , 1963, Progress in medicinal chemistry.

[16]  J. Millichap.  Studies in febrile seizures. I. Height of body temperature as a measure of the febrile-seizure threshold. , 1959, Pediatrics.

[17]  A. Ward,et al.  Failure of hyperthermia to activate experimental epileptogenic foci in monkey. , 1956, The Journal of pediatrics.