Radiation-induced skull base leiomyosarcoma presenting with intracerebral haemorrhage.

Radiation-induced neoplasm including meningioma, glioma and sarcoma, is an uncommon but known consequence after therapeutic irradiation of pituitary tumour. Radiation-induced leiomyosarcoma due to previous sellar irradiation has only been reported once in the literature. We herein present the second case of radiation-induced leiomyosarcoma that happened 17 years after radiation therapy for pituitary adenoma. The case is unique in its initial presentation, i.e. acute intracerebral haemorrhage. To the best of our knowledge, such an acute and severe presentation has never been reported in radiation-induced neoplasm following radiotherapy for pituitary adenoma.

[1]  S. Ashley,et al.  Risk of second brain tumor after conservative surgery and radiotherapy for pituitary adenoma: update after an additional 10 years. , 2005, The Journal of clinical endocrinology and metabolism.

[2]  K. Hashi,et al.  Radiation induced intracranial leiomyosarcoma: Its histopathological features , 2005, Acta Neurochirurgica.

[3]  R. Delfini,et al.  Radiation-induced gliomas: report of 10 cases and review of the literature. , 2003, Surgical neurology.

[4]  W. Hader,et al.  Primitive neuroectodermal tumors in the central nervous system following cranial irradiation , 2003, Cancer.

[5]  S. Ashley,et al.  Cerebrovascular mortality in patients with pituitary adenoma , 2002, Clinical endocrinology.

[6]  D. Nass,et al.  Radiation-induced meningioma: a descriptive study of 253 cases. , 2002, Journal of neurosurgery.

[7]  L. Hagmar,et al.  Is there an increase in second brain tumours after surgery and irradiation for a pituitary tumour? , 2001, Clinical endocrinology.

[8]  D. Taylor,et al.  Postradiation sarcomas: 20 cases and a literature review. , 1999, International journal of radiation oncology, biology, physics.

[9]  S. Ashley,et al.  The incidence of cerebrovascular accidents in patients with pituitary adenoma. , 1999, International journal of radiation oncology, biology, physics.

[10]  H. Woodard,et al.  Sarcoma arising in irradiated bone , 1998, Cancer.

[11]  E. Laws,et al.  Glioma occurrence after sellar irradiation: case report and review. , 1998, Neurosurgery.

[12]  A. DeSalles,et al.  Multiple radiation-induced intracranial lesions after treatment for pituitary adenoma. Case report. , 1998, Journal of neurosurgery.

[13]  P. Flandroy,et al.  Radiation-induced gliosarcoma. Case report and review of the literature. , 1995, Journal of neurosurgery.

[14]  M. Prados,et al.  Sarcomas subsequent to cranial irradiation. , 1995, Neurosurgery.

[15]  R. Tsang,et al.  Glioma arising after radiation therapy for pituitary adenoma. A report of four patients and estimation of risk , 1993, Cancer.

[16]  J. Bliss,et al.  Risk of second brain tumour after conservative surgery and radiotherapy for pituitary adenoma. , 1992, BMJ.

[17]  L. Robison,et al.  Second neoplasms after acute lymphoblastic leukemia in childhood. , 1991, The New England journal of medicine.

[18]  R. Mitnick,et al.  Radiation-induced meningiomas: experience at the Mount Sinai Hospital and review of the literature. , 1991, Journal of neurosurgery.

[19]  B. Modan,et al.  Tumors of the brain and nervous system after radiotherapy in childhood. , 1988, The New England journal of medicine.

[20]  B. Aron,et al.  Radiation-associated gliomas: a report of four cases and analysis of postradiation tumors of the central nervous system. , 1985, Neurosurgery.

[21]  M. Cohen,et al.  Radiation-induced cerebral meningioma: a recognizable entity. , 1984, Journal of neurosurgery.

[22]  M. Bernstein,et al.  Radiation-induced cerebellar chondrosarcoma. Case report. , 1984, Journal of neurosurgery.

[23]  J. Gonzalez‐Vitale,et al.  Radiation‐induced intracranial malignant fibrous histiocytoma , 1976, Cancer.

[24]  O. Sugar,et al.  Suprasellar osteogenic sarcoma following radiation for pituitary adenoma. Case report. , 1976, Journal of neurosurgery.

[25]  H. Woodard,et al.  Sarcoma in irradiated bone. Report of eleven cases , 1948 .