Spatially-enhanced time-domain NIRS for determination of optical properties in layered structures

A multivariate method integrating time-domain and space-domain techniques of near-infrared spectroscopy is proposed for simultaneously retrieving the absolute quantities of optical scattering and absorption properties in tissues. The concept is theoretically demonstrated by Monte-Carlo simulations in the homogenous case, and then applied on twolayer liquid phantoms. The deviations from nominal values are typically less than 6% for absorption coefficients in both layers