A dual-targeting peptide for glioblastoma screened by phage display peptide library biopanning combined with affinity-adaptability analysis.

[1]  Y. Liu,et al.  Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway , 2022, BMC Infectious Diseases.

[2]  Ke Men,et al.  ALPPL2‐Binding Peptide Facilitates Targeted mRNA Delivery for Efficient Hepatocellular Carcinoma Gene Therapy , 2022, Advanced Functional Materials.

[3]  Ahmed S. Doghish,et al.  Megalin, a multi-ligand endocytic receptor, and its participation in renal function and diseases: A review. , 2022, Life sciences.

[4]  Seyedeh Sara Esnaashari,et al.  Polymeric nanoparticles for drug delivery in glioblastoma: State of the art and future perspectives. , 2022, Journal of controlled release : official journal of the Controlled Release Society.

[5]  Olga E. Furman,et al.  Novel Cyclic Peptides for Targeting EGFR and EGRvIII Mutation for Drug Delivery , 2022, Pharmaceutics.

[6]  Chen Jiang,et al.  Brain-targeting drug delivery systems. , 2022, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[7]  Nesrine S. El‐Mezayen,et al.  Vitamin B12 as a Cholinergic System Modulator and Blood Brain Barrier Integrity Restorer in Alzheimer's Disease. , 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[8]  J. Nicoll,et al.  Glioblastoma, IDH-wildtype: A New Association with IgM Paraproteinaemic Neuropathy? , 2022, Case Reports in Neurology.

[9]  JaeHyung Koo,et al.  Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas: a systematic analysis and review , 2021, BMB reports.

[10]  Lidia Gaffke,et al.  Phage display and other peptide display technologies. , 2021, FEMS microbiology reviews.

[11]  B. Engelhardt,et al.  Nano-scale architecture of blood-brain barrier tight-junctions , 2021, bioRxiv.

[12]  Y. Lo,et al.  Lipid polymeric nanoparticles modified with tight junction-modulating peptides promote afatinib delivery across a blood–brain barrier model , 2021, Cancer Nanotechnology.

[13]  Xin-guo Jiang,et al.  Rethinking CRITID Procedure of Brain Targeting Drug Delivery: Circulation, Blood Brain Barrier Recognition, Intracellular Transport, Diseased Cell Targeting, Internalization, and Drug Release , 2021, Advanced science.

[14]  A. Iyer,et al.  LDL receptors and their role in targeted therapy for glioma: a review. , 2021, Drug discovery today.

[15]  M. Mizoguchi,et al.  Pediatric Glioma: An Update of Diagnosis, Biology, and Treatment , 2021, Cancers.

[16]  Xiaokun Li,et al.  FGF20 Protected Against BBB Disruption After Traumatic Brain Injury by Upregulating Junction Protein Expression and Inhibiting the Inflammatory Response , 2021, Frontiers in Pharmacology.

[17]  D. Gryko,et al.  Response of Human Glioblastoma Cells to Vitamin B12 Deficiency: A Study Using the Non-Toxic Cobalamin Antagonist , 2021, Biology.

[18]  Liang Han,et al.  Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies , 2020, Acta pharmaceutica Sinica. B.

[19]  J. Barnholtz-Sloan,et al.  Corrigendum to: CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017. , 2020, Neuro-oncology.

[20]  A. Sundan,et al.  Receptor binding competition: A paradigm for regulating TGF-β family action. , 2020, Cytokine & growth factor reviews.

[21]  J. Barnholtz-Sloan,et al.  CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017. , 2020, Neuro-oncology.

[22]  Shaoying Lu,et al.  Screening and identification of a CD44v6 specific peptide using improved phage display for gastric cancer targeting , 2020, Annals of translational medicine.

[23]  Thorsten Wohland,et al.  Illuminating the path to target GPCR structures and functions. , 2020, Biochemistry.

[24]  Qingqing Wang,et al.  Transferrin Receptor-Targeted PEG-PLA Polymeric Micelles for Chemotherapy Against Glioblastoma Multiforme , 2020, International journal of nanomedicine.

[25]  S. Laurent,et al.  Development of an LDL Receptor-Targeted Peptide Susceptible to Facilitate the Brain Access of Diagnostic or Therapeutic Agents , 2020, Biology.

[26]  Chris de Graaf,et al.  Advances in therapeutic peptides targeting G protein-coupled receptors , 2020, Nature Reviews Drug Discovery.

[27]  A. C. Duarte,et al.  The senses of the choroid plexus , 2019, Progress in Neurobiology.

[28]  Costas D. Arvanitis,et al.  The blood–brain barrier and blood–tumour barrier in brain tumours and metastases , 2019, Nature Reviews Cancer.

[29]  T. Webster,et al.  Glioma-targeted dual functionalized thermosensitive Ferri-liposomes for drug delivery through an in vitro blood-brain barrier. , 2019, Nanoscale.

[30]  Ronnie H. Fang,et al.  Ligand-Modified Cell Membrane Enables the Targeted Delivery of Drug Nanocrystals to Glioma. , 2019, ACS nano.

[31]  G. Yin,et al.  Novel Bi-Functional 14-mer Peptides with Both Ovarian Carcinoma Cells Targeting and Magnetic Fe3O4 Nanoparticles Affinity , 2019, Materials.

[32]  B. Brüne,et al.  Iron as a Central Player and Promising Target in Cancer Progression , 2019, International journal of molecular sciences.

[33]  M. Babu,et al.  Mechanisms of signalling and biased agonism in G protein-coupled receptors , 2018, Nature Reviews Molecular Cell Biology.

[34]  G. Rao,et al.  Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a , 2018, Scientific Reports.

[35]  Catherine L. Worth,et al.  Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level , 2017, Cellular and Molecular Life Sciences.

[36]  Philip S Low,et al.  Ligand-Targeted Drug Delivery. , 2017, Chemical reviews.

[37]  Ping Hu,et al.  Activation of β-adrenergic receptor promotes cellular proliferation in human glioblastoma. , 2017, Oncology letters.

[38]  J. Sarkaria,et al.  Drug delivery to melanoma brain metastases: Can current challenges lead to new opportunities? , 2017, Pharmacological research.

[39]  G. Yin,et al.  Glioma targeted delivery strategy of doxorubicin-loaded liposomes by dual-ligand modification , 2017, Journal of biomaterials science. Polymer edition.

[40]  G. Szakács,et al.  NGR-peptide−drug conjugates with dual targeting properties , 2017, PloS one.

[41]  Salvatore Gitto,et al.  Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and Microbubbles , 2017, PloS one.

[42]  Fan Yang,et al.  Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery , 2016, Proceedings of the National Academy of Sciences.

[43]  Zhi Zhu,et al.  Advance in phage display technology for bioanalysis , 2016, Biotechnology journal.

[44]  G. Yin,et al.  Biopanning and characterization of peptides with Fe3O4 nanoparticles-binding capability via phage display random peptide library technique. , 2016, Colloids and surfaces. B, Biointerfaces.

[45]  M. Ghosh,et al.  Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors , 2015, BioMed research international.

[46]  E. Shusta,et al.  Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier. , 2015, Annual review of pharmacology and toxicology.

[47]  T. Hla,et al.  An update on the biology of sphingosine 1-phosphate receptors , 2014, Journal of Lipid Research.

[48]  E. Ramos-Fernández,et al.  The blood-brain barrier: Structure, function and therapeutic approaches to cross it , 2014, Molecular membrane biology.

[49]  Yuefei Yu,et al.  Overexpression of netrin-1 increases the expression of tight junction-associated proteins, claudin-5, occludin, and ZO-1, following traumatic brain injury in rats , 2014, Experimental and therapeutic medicine.

[50]  Yoav Mayshar,et al.  Mfsd2a is critical for the formation and function of the blood–brain barrier , 2014, Nature.

[51]  J. Elstrott,et al.  Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants , 2014, The Journal of experimental medicine.

[52]  Xin-guo Jiang,et al.  Glioma-homing peptide with a cell-penetrating effect for targeting delivery with enhanced glioma localization, penetration and suppression of glioma growth. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[53]  Chen Jiang,et al.  T7 peptide-functionalized nanoparticles utilizing RNA interference for glioma dual targeting. , 2013, International journal of pharmaceutics.

[54]  T. Nishioku,et al.  Paracellular barrier and tight junction protein expression in the immortalized brain endothelial cell lines bEND.3, bEND.5 and mouse brain endothelial cell 4. , 2013, Biological & pharmaceutical bulletin.

[55]  M. Babu,et al.  Molecular signatures of G-protein-coupled receptors , 2013, Nature.

[56]  Kelvin H. Lee,et al.  Membrane configuration optimization for a murine in vitro blood–brain barrier model , 2013, Journal of Neuroscience Methods.

[57]  A. Gaultier,et al.  LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin , 2013, Journal of Cell Science.

[58]  S. Ortolano,et al.  LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease , 2012, Front. Physio..

[59]  S. Iwata,et al.  G protein-coupled receptor inactivation by an allosteric inverse-agonist antibody , 2011, Nature.

[60]  Forrest M Kievit,et al.  Cancer Nanotheranostics: Improving Imaging and Therapy by Targeted Delivery Across Biological Barriers , 2011, Advanced materials.

[61]  W. Luk,et al.  Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target , 2011, Science Translational Medicine.

[62]  Rongqin Huang,et al.  Targeted delivery of chlorotoxin-modified DNA-loaded nanoparticles to glioma via intravenous administration. , 2011, Biomaterials.

[63]  Yunhui Liu,et al.  Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood–Brain Barrier in a Focal Cerebral Ischemic Insult , 2011, Journal of Molecular Neuroscience.

[64]  H. Schuller.  Beta-adrenergic signaling, a novel target for cancer therapy? , 2010, Oncotarget.

[65]  A. Jemal,et al.  Cancer Statistics, 2010 , 2010, CA: a cancer journal for clinicians.

[66]  K. Brown.  Peptidic tumor targeting agents: the road from phage display peptide selections to clinical applications. , 2010, Current pharmaceutical design.

[67]  Rongqin Huang,et al.  Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles. , 2009, Biomaterials.

[68]  Á. Kittel,et al.  A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes , 2009, Neurochemistry International.

[69]  Qing X. Yang,et al.  Efficacy of interleukin-13 receptor–targeted liposomal doxorubicin in the intracranial brain tumor model , 2009, Molecular Cancer Therapeutics.

[70]  B. Wiesner,et al.  Formation of tight junction: determinants of homophilic interaction between classic claudins , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[71]  R. Quarles.  Myelin‐associated glycoprotein (MAG): past, present and beyond , 2007, Journal of neurochemistry.

[72]  G. Giovannoni,et al.  The role of antibody affinity for specific antigens in the differential diagnosis of inflammatory nervous system disorders , 2006, Journal of Neuroimmunology.

[73]  K. Hayashi,et al.  Adrenomedullin Improves the Blood–Brain Barrier Function Through the Expression of Claudin-5 , 2006, Cellular and Molecular Neurobiology.

[74]  A. Berezov,et al.  HER2-mediated internalization of a targeted prodrug cytotoxic conjugate is dependent on the valency of the targeting ligand. , 2005, DNA and cell biology.

[75]  M. Ryan,et al.  Occludin: structure, function and regulation. , 2005, Advanced drug delivery reviews.

[76]  C. McArdle,et al.  The Gonadotrophin-Releasing Hormone Receptor: Signalling, Cycling and Desensitisation , 2002, Archives of physiology and biochemistry.

[77]  P. Zandstra,et al.  Concentration-dependent internalization of a cytokine/cytokine receptor complex in human hematopoietic cells. , 1999, Biotechnology and bioengineering.

[78]  R. Broadwell,et al.  Transcytosis of Protein through the Mammalian Cerebral Epithelium and Endothelium III. Receptor-Mediated Transcytosis through the Blood–Brain Barrier of Blood-Borne Transferrin and Antibody against the Transferrin Receptor , 1996, Experimental Neurology.

[79]  K. Angelides,et al.  Ligand-stimulated beta 2-adrenergic receptor internalization via the constitutive endocytic pathway into rab5-containing endosomes. , 1995, Journal of cell science.

[80]  D. Strickland,et al.  Glycoprotein 330/Low Density Lipoprotein Receptor-related Protein-2 Mediates Endocytosis of Low Density Lipoproteins via Interaction with Apolipoprotein B100 (*) , 1995, The Journal of Biological Chemistry.

[81]  F. Maxfield,et al.  Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome , 1989, The Journal of cell biology.

[82]  W. Jefferies,et al.  Transferrin receptor on endothelium of brain capillaries , 1984, Nature.

[83]  G. Yin,et al.  Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd2O3 nanorods with dual-model imaging and targeted therapy of brain tumor , 2020 .

[84]  N. Davis-Poynter,et al.  Virus-encoded 7 transmembrane receptors. , 2015, Progress in molecular biology and translational science.

[85]  E. Hansson,et al.  Astrocyte–endothelial interactions at the blood–brain barrier , 2006, Nature Reviews Neuroscience.

[86]  Ș. Purcaru,et al.  Oncotargets and Therapy Dovepress Epidermal Growth Factor, Latrophilin, and Seven Transmembrane Domain-containing Protein 1 Marker, a Novel Angiogenesis Marker , 2022 .

[87]  JoVE Video Dataset , 2022 .