RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1

[1]  Luc Girard,et al.  ZEB1 drives epithelial-to-mesenchymal transition in lung cancer. , 2016, The Journal of clinical investigation.

[2]  Limei Liu,et al.  MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. , 2016, Cancer research.

[3]  M. Freeman,et al.  Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα , 2016, Scientific Reports.

[4]  Jaime Rodriguez-Canales,et al.  A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition , 2015, Clinical Cancer Research.

[5]  Wenjie Liu,et al.  Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway , 2015, Nature Communications.

[6]  Hong Liu,et al.  Epithelial-mesenchymal transition in colorectal cancer metastasis: A system review. , 2015, Pathology, research and practice.

[7]  H. Moch,et al.  ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1 , 2014, Nature Cell Biology.

[8]  M. Freeman.  The rhomboid-like superfamily: molecular mechanisms and biological roles. , 2014, Annual review of cell and developmental biology.

[9]  Eduard Batlle,et al.  Metastatic stem cells: sources, niches, and vital pathways. , 2014, Cell stem cell.

[10]  M. Abba,et al.  Rhomboid family gene expression profiling in breast normal tissue and tumor samples , 2014, Tumor Biology.

[11]  J. Gray,et al.  CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression. , 2014, Cancer research.

[12]  Jing Yang,et al.  Epithelial–mesenchymal plasticity in carcinoma metastasis , 2013, Genes & development.

[13]  Le Cong,et al.  Multiplex Genome Engineering Using CRISPR/Cas Systems , 2013, Science.

[14]  Jiuhong Kang,et al.  Involvement of ZEB1 and E-cadherin in the invasion of lung squamous cell carcinoma , 2013, Molecular Biology Reports.

[15]  P. Jung,et al.  Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. , 2012, Cancer cell.

[16]  M. Abba,et al.  RHBDD2: a 5-fluorouracil responsive gene overexpressed in the advanced stages of colorectal cancer , 2012, Tumor Biology.

[17]  M. K. Lemberg,et al.  Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins. , 2012, Molecular cell.

[18]  C. Wan,et al.  Exosome-Related Multi-Pass Transmembrane Protein TSAP6 Is a Target of Rhomboid Protease RHBDD1-Induced Proteolysis , 2012, PloS one.

[19]  Paul Polakis,et al.  Wnt signaling in cancer. , 2012, Cold Spring Harbor perspectives in biology.

[20]  A. Postigo,et al.  β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness , 2011, Proceedings of the National Academy of Sciences.

[21]  S. Urban,et al.  The rhomboid protease family: a decade of progress on function and mechanism , 2011, Genome Biology.

[22]  Robert A. Weinberg,et al.  Tumor Metastasis: Molecular Insights and Evolving Paradigms , 2011, Cell.

[23]  Hans Clevers,et al.  The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. , 2011, Cell stem cell.

[24]  R. Weinberg,et al.  A Perspective on Cancer Cell Metastasis , 2011, Science.

[25]  H. Brenner,et al.  Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. , 2010, Carcinogenesis.

[26]  Julia Schüler,et al.  The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs , 2009, Nature Cell Biology.

[27]  Michael F. Clarke,et al.  Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells , 2009, Cell.

[28]  M. Freeman.  Rhomboid proteases and their biological functions. , 2008, Annual review of genetics.

[29]  S. Li,et al.  A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis , 2008, Cellular and Molecular Life Sciences.

[30]  A. Dimmler,et al.  The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. , 2008, Cancer research.

[31]  Gordon B. Mills,et al.  Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity* , 2007, Journal of Biological Chemistry.

[32]  Leroy Hood,et al.  PTEN-deficient intestinal stem cells initiate intestinal polyposis , 2007, Nature Genetics.

[33]  J. Massagué,et al.  Cancer Metastasis: Building a Framework , 2006, Cell.

[34]  N. Dulin,et al.  Phosphorylation of β-Catenin by Cyclic AMP-dependent Protein Kinase* , 2006, Journal of Biological Chemistry.

[35]  H. Clevers,et al.  Wnt signalling in stem cells and cancer , 2005, Nature.

[36]  S. Ramaswamy,et al.  Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis , 2004, Cell.

[37]  Francisco Portillo,et al.  The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression , 2000, Nature Cell Biology.

[38]  A. G. Herreros,et al.  The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells , 2000, Nature Cell Biology.

[39]  M. Dirnhuber,et al.  System review , 1989 .

[40]  N. Dulin,et al.  Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase. , 2006, The Journal of biological chemistry.

[41]  J. Hardcastle,et al.  Colorectal cancer , 1993, Europe Against Cancer European Commission Series for General Practitioners.