论文信息 - Development of a CMOS-based implantable device for wide-area brain functional imaging

Development of a CMOS-based implantable device for wide-area brain functional imaging

We have developed a CMOS image sensor with hexagonally shaped outline for wide-area brain functional imaging. The hexagonal shape of the sensor chip allows covering wide area on curved surface of the brain by placing multiple chips. In this paper, we report two results for wide-area brain functional imaging. First, we designed a hexagonally shaped CMOS-based imaging device which has highly sensitive pixels and evaluated the characteristics of the sensor. Second, we successfully demonstrated fluorescent imaging using the sensor.

[1] Toshio Iijima,et al. High-speed CCD imaging system for monitoring neural activity in vivo and in vitro, using a voltage-sensitive dye , 1999, Journal of Neuroscience Methods.

[2] Jun Ohta,et al. Development of Complementary Metal Oxide Semiconductor Imaging Devices for Detecting Green Fluorescent Protein in the Deep Brain of a Freely Moving Mouse , 2009 .

[3] Eduardo Soriano,et al. Neuronal Activity Regulates Correlated Network Properties of Spontaneous Calcium Transients in Astrocytes In Situ , 2002, The Journal of Neuroscience.

[4] Karel Svoboda,et al. Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice , 2010, Nature.

[5] Jun Ohta,et al. Functional neuroimaging by using an implantable CMOS multimodal device in a freely-moving mouse , 2011, 2011 IEEE Biomedical Circuits and Systems Conference (BioCAS).