Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial.

[1]  Pamela R. Tsuruda,et al.  Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results. , 2024, Nature medicine.

[2]  Shiva Kazempour Dehkordi,et al.  Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial , 2023, Nature Medicine.

[3]  R. Eastell,et al.  Bone Turnover Markers: Basic Biology to Clinical Applications , 2022, Endocrine reviews.

[4]  J. Kirkland,et al.  Cellular senescence and senolytics: the path to the clinic , 2022, Nature Medicine.

[5]  N. LeBrasseur,et al.  A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues , 2021, Nature Communications.

[6]  Brian R. Kotajarvi,et al.  The senescence-associated secretome as an indicator of age and medical risk. , 2020, JCI insight.

[7]  D. Levêque,et al.  Clinical Pharmacokinetics and Pharmacodynamics of Dasatinib , 2020, Clinical Pharmacokinetics.

[8]  Shahrukh K Hashmi,et al.  Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease , 2019, EBioMedicine.

[9]  G. Ferbeyre,et al.  The senescence-associated secretory phenotype and its regulation. , 2019, Cytokine.

[10]  S. Kritchevsky,et al.  Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study , 2019, EBioMedicine.

[11]  N. LeBrasseur,et al.  Targeting cellular senescence prevents age-related bone loss in mice , 2017, Nature Medicine.

[12]  S. Khosla,et al.  Hormonal and systemic regulation of sclerostin. , 2017, Bone.

[13]  P. Robbins,et al.  New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 , 2017, Aging.

[14]  Ivana Y. Kuo,et al.  Low-dose dasatinib rescues cardiac function in Noonan syndrome. , 2016, JCI insight.

[15]  N. LeBrasseur,et al.  Identification of Senescent Cells in the Bone Microenvironment , 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[16]  L. Akard,et al.  Long-Term Side Effects of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia , 2016, Current Hematologic Malignancy Reports.

[17]  A. Pezeshki,et al.  Naturally occurring p16Ink4a-positive cells shorten healthy lifespan , 2016, Nature.

[18]  N. Sharpless,et al.  Role of senescence marker p16INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults , 2016, Experimental Gerontology.

[19]  N. Sharpless,et al.  Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice , 2015, Nature Medicine.

[20]  G. D'andrea.  Quercetin: A flavonol with multifaceted therapeutic applications? , 2015, Fitoterapia.

[21]  N. LeBrasseur,et al.  The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs , 2015, Aging cell.

[22]  S. Khosla,et al.  In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  L. Carey,et al.  Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer. , 2014, Journal of the National Cancer Institute.

[24]  S. Khosla,et al.  Relationship of sympathetic activity to bone microstructure, turnover, and plasma osteopontin levels in women. , 2012, The Journal of clinical endocrinology and metabolism.

[25]  N. LeBrasseur,et al.  Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders , 2011, Nature.

[26]  N. Sharpless,et al.  Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging , 2009, Aging cell.

[27]  Y. Moon,et al.  Quercetin pharmacokinetics in humans , 2008, Biopharmaceutics & drug disposition.

[28]  Trees-Juen Chuang,et al.  Human p16γ, a novel transcriptional variant of p16INK4A, coexpresses with p16INK4A in cancer cells and inhibits cell-cycle progression , 2007, Oncogene.

[29]  J. Sedivy,et al.  Cellular Senescence in Aging Primates , 2006, Science.

[30]  L. Hayflick,et al.  The serial cultivation of human diploid cell strains. , 1961, Experimental cell research.

[31]  R. Eastell,et al.  Changes in Bone Mass and Bone Turnover Following Distal Forearm Fracture , 1999, Osteoporosis International.