ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation

[1]  G. Domenici,et al.  Tackling the tumor microenvironment – how can complex tumor models in vitro aid oncology drug development? , 2023, Expert opinion on drug discovery.

[2]  G. Kollias,et al.  Mesenchymal cells in health and disease , 2022, Nature Immunology.

[3]  Andrew P. Bowman,et al.  Sphingolipids control dermal fibroblast heterogeneity , 2022, Science.

[4]  R. Kalluri,et al.  Clinical and therapeutic relevance of cancer-associated fibroblasts , 2021, Nature Reviews Clinical Oncology.

[5]  Oriol Vinyals,et al.  Highly accurate protein structure prediction with AlphaFold , 2021, Nature.

[6]  Hongmei Zhou,et al.  Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer , 2021, Signal Transduction and Targeted Therapy.

[7]  G. Kollias,et al.  Fibroblasts as immune regulators in infection, inflammation and cancer , 2021, Nature Reviews Immunology.

[8]  B. Ludewig,et al.  The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis , 2021, International journal of molecular sciences.

[9]  J. Campisi,et al.  Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging. , 2020, The Journal of investigative dermatology.

[10]  G. Dotto,et al.  NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin , 2020, Nature Communications.

[11]  R. Langer,et al.  Advances in oligonucleotide drug delivery , 2020, Nature Reviews Drug Discovery.

[12]  J. Loyd,et al.  Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis , 2020, Science Advances.

[13]  G. Ciriello,et al.  Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis , 2020, bioRxiv.

[14]  D. Tuveson,et al.  DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS. , 2020, Physiological reviews.

[15]  P. Mohler,et al.  Advancing our understanding of AnkRD1 in cardiac development and disease. , 2020, Cardiovascular research.

[16]  S. Werner,et al.  A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming , 2020, EMBO molecular medicine.

[17]  Thea D. Tlsty,et al.  A framework for advancing our understanding of cancer-associated fibroblasts , 2020, Nature Reviews Cancer.

[18]  E. Guenova,et al.  Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant , 2019, Cell reports.

[19]  K. Zibara,et al.  The AP-1 transcriptional complex: Local switch or remote command? , 2019, Biochimica et biophysica acta. Reviews on cancer.

[20]  Qihao Ren,et al.  Unmasking senescence: context-dependent effects of SASP in cancer , 2019, Nature Reviews Cancer.

[21]  Melissa J. Davis,et al.  Single sample scoring of molecular phenotypes , 2018, BMC Bioinformatics.

[22]  Pedro Madrigal,et al.  AP-1 Takes Centre Stage in Enhancer Chromatin Dynamics. , 2018, Trends in cell biology.

[23]  S. Werner,et al.  Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome. , 2018, Developmental cell.

[24]  C. Martins,et al.  Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells , 2018, Nature Communications.

[25]  Shawn M. Gillespie,et al.  Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer , 2017, Cell.

[26]  Kathleen M Jagodnik,et al.  Massive mining of publicly available RNA-seq data from human and mouse , 2017, Nature Communications.

[27]  Dong Eun Kim,et al.  Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation , 2017, The Journal of experimental medicine.

[28]  Yaoyong Li,et al.  Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma , 2017, PLoS genetics.

[29]  O. Liew,et al.  Ankyrin Repeat Domain 1 Protein: A Functionally Pleiotropic Protein with Cardiac Biomarker Potential , 2017, International journal of molecular sciences.

[30]  Irving L. Weissman,et al.  Unifying mechanism for different fibrotic diseases , 2017, Proceedings of the National Academy of Sciences.

[31]  D. Tuveson,et al.  Br Ief Definitive Repor T , 2022 .

[32]  R. Kalluri.  The biology and function of fibroblasts in cancer , 2016, Nature Reviews Cancer.

[33]  A. Bosio,et al.  Depletion of Mouse Cells from Human Tumor Xenografts Significantly Improves Downstream Analysis of Target Cells. , 2016, Journal of visualized experiments : JoVE.

[34]  Andrew D. Rouillard,et al.  The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins , 2016, Database J. Biol. Databases Curation.

[35]  P. Gascard,et al.  Carcinoma-associated fibroblasts: orchestrating the composition of malignancy , 2016, Genes & development.

[36]  Charles H. Yoon,et al.  Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq , 2016, Science.

[37]  G C P van Zundert,et al.  The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes. , 2016, Journal of molecular biology.

[38]  Antonio Rosato,et al.  Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth , 2015, Nature Cell Biology.

[39]  Dong Eun Kim,et al.  Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation , 2015, Nature Cell Biology.

[40]  Nathan C. Sheffield,et al.  ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors , 2015, Nature Methods.

[41]  J. Reid,et al.  A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer , 2015, BMC Cancer.

[42]  Steven J. M. Jones,et al.  Comprehensive genomic characterization of head and neck squamous cell carcinomas , 2015, Nature.

[43]  R. Sanz-Pamplona,et al.  Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information , 2014, Molecular oncology.

[44]  M. Januszyk,et al.  Tacrolimus fails to regulate collagen expression in dermal fibroblasts. , 2013, The Journal of surgical research.

[45]  N. Elvassore,et al.  A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors , 2013, Cell.

[46]  A. Nicholson,et al.  Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease , 2013, Respiratory Research.

[47]  Robert P. Jenkins,et al.  Mechano-transduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer associated fibroblasts , 2013, Nature Cell Biology.

[48]  Avi Ma'ayan,et al.  Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool , 2013, BMC Bioinformatics.

[49]  H. Soifer,et al.  Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids , 2012, Molecular therapy. Nucleic acids.

[50]  A. Reymond,et al.  Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling , 2012, Cell.

[51]  Aik Choon Tan,et al.  Patient-derived tumour xenografts as models for oncology drug development , 2012, Nature Reviews Clinical Oncology.

[52]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[53]  Clifford A. Meyer,et al.  Cistrome: an integrative platform for transcriptional regulation studies , 2011, Genome Biology.

[54]  Nikolina Radulovich,et al.  Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer , 2011, Proceedings of the National Academy of Sciences.

[55]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[56]  Helga Thorvaldsdóttir,et al.  Integrative Genomics Viewer , 2011, Nature Biotechnology.

[57]  N. Bourg,et al.  A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor‐κB pathway in skeletal muscle , 2010, The FEBS journal.

[58]  C. Glass,et al.  Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. , 2010, Molecular cell.

[59]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[60]  A. Rosenberg,et al.  Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 down-regulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy , 2008, Cancer biology & therapy.

[61]  S. Hirono,et al.  Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1 , 2008, Nature Biotechnology.

[62]  G. T. Bowden,et al.  UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. , 2004, Seminars in cancer biology.

[63]  E. Wagner,et al.  AP-1: a double-edged sword in tumorigenesis , 2003, Nature Reviews Cancer.

[64]  M. Karin,et al.  AP-1 as a regulator of cell life and death , 2002, Nature Cell Biology.

[65]  R. Swerlick,et al.  Identification and Characterization of a Novel Cytokine-inducible Nuclear Protein from Human Endothelial Cells (*) , 1995, The Journal of Biological Chemistry.

[66]  J. N. Mark Glover,et al.  Crystal structure of the heterodimeric bZIP transcription factor c-Fos–c-Jun bound to DNA , 1995, Nature.

[67]  OUP accepted manuscript , 2021, Nucleic Acids Research.

[68]  J. Davidson,et al.  Global deletion of Ankrd1 results in a wound-healing phenotype associated with dermal fibroblast dysfunction. , 2015, The American journal of pathology.