Thiadiazole: An amazing anticancer moeity

Cancer is a general name for a group of more than 100 diseases in which cells belonging to a part of the body, begin uncontrolled proliferation. Nowadays, cancer is an important public health problem in all countries. For decades, conventional chemotherapy has been the most common type of anticancer pharmacotherapy. Cancer chemotherapy has been one of the major advances in the field of medicine in the last few decades. However, drugs administered for chemotherapy have a narrow therapeutic index and therefore, there is a high incidence of unwanted side effects. Thiadiazole is a five-membered ring system that has gained prominence by exhibiting a wide variety of biological activities. It has interesting pharmacophores that display a broad spectrum biological activity. The lower toxicity and in vivo stability of 1,3,4-thiadiazole nucleus are attributed to its aromaticity. Thiadiazole has exhibited potential antiglaucoma, antiinflammatory, antitumor, antiulcer, antibacterial, antiviral, analgesic, antiepileptic, antifungal and radioprotective activities. In this review article antitumor activity of various thiadiazole derivatives has been discussed.

[1]  Ahmed SAA,et al.  Research Journal of Pharmaceutical, Biological and Chemical Sciences , 2012 .

[2]  A. Aliabadi,et al.  Synthesis and Evaluation of the Cytotoxicity of a Series of 1,3,4-Thiadiazole Based Compounds as Anticancer Agents , 2013, Iranian journal of basic medical sciences.

[3]  C. S. Shah,et al.  Synthesis, in vitro anticancer and antioxidant activity of thiadiazole substituted thiazolidin-4-ones , 2013, Acta pharmaceutica.

[4]  Ramandeep Singh,et al.  Report on Biological Activities of Thiadiazole Derivatives: A Review , 2013 .

[5]  S. Kushwaha,et al.  Biological Activities of Thiadiazole Derivatives: A Review , 2012 .

[6]  B. Kalluraya,et al.  Microwave assisted synthesis of triazolothiadiazole analogues as anticancer and antibacterial agents , 2012 .

[7]  W. Rzeski,et al.  The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells. , 2011, Folia histochemica et cytobiologica.

[8]  S. Cameotra,et al.  Synthesis and anticancer evaluation of novel 2-cyclopropylimidazo[2,1-b][1,3,4]-thiadiazole derivatives. , 2011, European journal of medicinal chemistry.

[9]  Amandeep Kaur,et al.  1, 3, 4-Thiadiazole Derivatives and their Biological Activities: A Review , 2011 .

[10]  B. Shah,et al.  Biological Profile of Thiadiazole , 2011 .

[11]  P. Sharma,et al.  Recent Advancements in the Synthesis and Pharmacological Evaluation of Substituted 1,3,4‐Thiadiazole Derivatives , 2010 .

[12]  P. Shetty,et al.  Synthesis, characterization and anticancer activity of 1,2,4-Triazolo [3,4-b]-1,3,4-thiadiazoles on Hep G2 cell lines , 2009 .

[13]  N. Siddiqui,et al.  Thiadiazoles: Progress Report on Biological Activities , 2009 .

[14]  Y. Ünver,et al.  Synthesis of 2-Acylamino, 2-Aroylamino and Ethoxycarbonyl Imino-1,3,4-thiadiazoles as Antitumor Agents , 2007 .

[15]  J. Matysiak,et al.  Synthesis and antiproliferative activity of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles. , 2006, Bioorganic & medicinal chemistry.

[16]  John H. Block,et al.  Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry , 1991 .