The technology of propellant refueling is one of the important technologies of spacelab and cargo ship rendezvous and docking mission. With the data management software system, the function of two aircraft docking bus network is established, and the function of data transmission and control is realized. In the spacelab task, a data management software system for propellant refueling of cargo spaceship was proposed. Firstly, the software requirements and design principles are analyzed. Then, the layered software architecture is designed, and the rendezvous and docking task is expatiated. Finally, the realization of propellant refueling process in spacelab and cargo ship is illustrated. The research results can provide an important basis for the design of the data management system for the propellant refueling on space station.