Unravelling the pathogenesis of inflammatory bowel disease

[1]  M. Weichenthal,et al.  Reduced Paneth cell alpha-defensins in ileal Crohn's disease. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[2]  N. Salzman,et al.  Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. , 2007, Seminars in immunology.

[3]  J. Meijerink,et al.  Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. , 2006, Gastroenterology.

[4]  Thomas Lengauer,et al.  A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 , 2007, Nature Genetics.

[5]  Judy H. Cho,et al.  A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease , 2001, Nature.

[6]  A. Young,et al.  Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. , 2000, Science.

[7]  F. Autschbach,et al.  Inflammatory bowel disease is associated with changes of enterocytic junctions. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[8]  N. Barnich,et al.  CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. , 2007, The Journal of clinical investigation.

[9]  A. Osterman,et al.  Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1 , 2007, Cell.

[10]  Tomohiro Watanabe,et al.  Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. , 2006, Immunity.

[11]  E. Lindberg,et al.  Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. , 1988, Gut.

[12]  A. Bhan,et al.  A Case for Regulatory B Cells1 , 2006, The Journal of Immunology.

[13]  S. Pettersson,et al.  Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA , 2004, Nature Immunology.

[14]  J. Glas,et al.  Crohn's disease is associated with a toll-like receptor-9 polymorphism. , 2004, Gastroenterology.

[15]  F. Martinon,et al.  A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses , 2007, Nature Immunology.

[16]  G. May,et al.  Is small intestinal permeability really increased in relatives of patients with Crohn's disease? , 1993, Gastroenterology.

[17]  M. Neurath,et al.  Epithelial NEMO links innate immunity to chronic intestinal inflammation , 2007, Nature.

[18]  L. Hennighausen,et al.  Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. , 2007, Immunity.

[19]  D. Podolsky,et al.  A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells. , 1999, The Journal of clinical investigation.

[20]  K. Papadakis,et al.  Expression and functional characterization of FOXP3+CD4+ regulatory T cells in ulcerative colitis , 2007, Inflammatory bowel diseases.

[21]  D. Podolsky,et al.  Inflammatory bowel disease. , 2002, The New England journal of medicine.

[22]  M. Chamaillard,et al.  NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. , 2005, Annual review of biochemistry.

[23]  V. Kuchroo,et al.  TH-17 cells in the circle of immunity and autoimmunity , 2007, Nature Immunology.

[24]  A. Kaser,et al.  Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. , 2006, The Journal of clinical investigation.

[25]  A. Gruber,et al.  Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis , 2007, Nature.

[26]  V. Deretic,et al.  Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria , 2006, Science.

[27]  Michael Karin,et al.  Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing , 2005, Science.

[28]  R. Ulevitch,et al.  SGT1 is essential for Nod1 activation , 2007, Proceedings of the National Academy of Sciences.

[29]  T. Sakaguchi,et al.  Claudins regulate the intestinal barrier in response to immune mediators. , 2000, Gastroenterology.

[30]  M. Leach,et al.  A role for NK cells as regulators of CD4+ T cells in a transfer model of colitis. , 1998, Journal of immunology.

[31]  P. Hawkins,et al.  Neutrophils from p40phox−/− mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing , 2006, The Journal of experimental medicine.

[32]  D. Podolsky.  Inflammatory bowel disease (Second of two parts) , 1991 .

[33]  Bill Newman,et al.  Functional variants of OCTN cation transporter genes are associated with Crohn disease , 2004, Nature Genetics.

[34]  D. Podolsky,et al.  Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors1 , 2000, The Journal of Immunology.

[35]  D. Goeddel,et al.  NF-κB-Inducing Kinase Regulates Selected Gene Expression in the Nod2 Signaling Pathway , 2006, Infection and Immunity.

[36]  I. Dotan,et al.  Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells. , 2002, Gastroenterology.

[37]  Robert S. Pinals,et al.  A double‐blind, placebo‐controlled trial , 1986 .

[38]  Judy H Cho,et al.  Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis , 2007, Nature Genetics.

[39]  C. Janeway,et al.  RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems , 2002, Nature.

[40]  I. Forgacs.  GASTROENTEROLOGY , 1988, The Lancet.

[41]  A. Rudensky,et al.  The role of the transcription factor Foxp3 in the development of regulatory T cells , 2006, Immunological reviews.

[42]  Richard A. Flavell,et al.  Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract , 2005, Science.

[43]  J. Bartlett,et al.  The role of the intestinal microflora in experimental colitis. , 1977, The American journal of clinical nutrition.

[44]  Hiroshi Sagara,et al.  Escape of Intracellular Shigella from Autophagy , 2005, Science.

[45]  R. Ley,et al.  Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine , 2006, Cell.

[46]  P. Rutgeerts,et al.  Toll‐like receptor‐1, ‐2, and ‐6 polymorphisms influence disease extension in inflammatory bowel diseases , 2006, Inflammatory bowel diseases.

[47]  M. Neurath,et al.  Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. , 2003, The Journal of clinical investigation.

[48]  P. Lécine,et al.  A Role for Erbin in the Regulation of Nod2-dependent NF-κB Signaling* , 2005, Journal of Biological Chemistry.

[49]  J. Cebon,et al.  Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway. , 2005, Blood.

[50]  K. H. Peterson,et al.  Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease , 2002, Gut.

[51]  Philippe Goyette,et al.  Molecular pathogenesis of inflammatory bowel disease: Genotypes, phenotypes and personalized medicine , 2007, Annals of medicine.

[52]  Hidde L Ploegh,et al.  CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance , 2005, Science.

[53]  M. Lazar,et al.  Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis. , 2006, The Journal of clinical investigation.

[54]  R. Xavier,et al.  GRIM-19 Interacts with Nucleotide Oligomerization Domain 2 and Serves as Downstream Effector of Anti-bacterial Function in Intestinal Epithelial Cells* , 2005, Journal of Biological Chemistry.

[55]  D. Klionsky,et al.  Protein turnover via autophagy: implications for metabolism. , 2007, Annual review of nutrition.

[56]  T. Sørensen,et al.  Familial occurrence of inflammatory bowel disease. , 1991, The New England journal of medicine.

[57]  C. Elson,et al.  Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota , 2005, Immunological reviews.

[58]  S. Akira,et al.  Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. , 1999, Immunity.

[59]  R. Blumberg,et al.  Dependence of intestinal granuloma formation on unique myeloid DC-like cells. , 2007, The Journal of clinical investigation.

[60]  J. Marshall,et al.  Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk. , 2000, Gastroenterology.

[61]  R. Germain,et al.  Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement , 2006, The Journal of experimental medicine.

[62]  Mourad Sahbatou,et al.  Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease , 2001, Nature.

[63]  M Schwab,et al.  NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression , 2004, Gut.

[64]  R. Coffman,et al.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.

[65]  T. Hibi,et al.  Abnormally Differentiated Subsets of Intestinal Macrophage Play a Key Role in Th1-Dominant Chronic Colitis through Excess Production of IL-12 and IL-23 in Response to Bacteria1 , 2005, The Journal of Immunology.

[66]  T. Mcclanahan,et al.  IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. , 2006, The Journal of clinical investigation.

[67]  S. Narumiya,et al.  The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. , 2002, The Journal of clinical investigation.

[68]  M. Pop,et al.  Metagenomic Analysis of the Human Distal Gut Microbiome , 2006, Science.

[69]  M. Dinauer,et al.  p40phox: the last NADPH oxidase subunit. , 2005, Blood cells, molecules & diseases.

[70]  K. Van Steen,et al.  Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis , 2004, Gut.

[71]  Judy H. Cho,et al.  A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene , 2006, Science.

[72]  D. Littman,et al.  The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells , 2006, Cell.

[73]  Judy H. Cho,et al.  Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease , 2007, European Journal of Human Genetics.

[74]  R. D. Hatton,et al.  IL-17 family cytokines and the expanding diversity of effector T cell lineages. , 2007, Annual review of immunology.

[75]  J. Ragoussis,et al.  Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. , 2005, Human molecular genetics.

[76]  B. Xia,et al.  Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans , 2007, The Journal of experimental medicine.

[77]  A. Akbar,et al.  The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery , 2007, Nature Reviews Immunology.

[78]  N. Barnich,et al.  Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease. , 1998, Gastroenterology.

[79]  I. Chinen,et al.  Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae , 2007, Proceedings of the National Academy of Sciences.

[80]  D. Podolsky,et al.  CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. , 2003, Gastroenterology.

[81]  F. Powrie,et al.  Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. , 2006, Immunity.

[82]  J. Coombes,et al.  Control of intestinal homeostasis by regulatory T cells and dendritic cells. , 2007, Seminars in immunology.

[83]  G. Taylor.  IRG proteins: key mediators of interferon‐regulated host resistance to intracellular pathogens , 2007, Cellular microbiology.

[84]  C. Ochsenbauer-Jambor,et al.  Intestinal macrophages: unique effector cells of the innate immune system , 2005, Immunological reviews.

[85]  Alastair Forbes,et al.  Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility , 2007, Nature Genetics.

[86]  R. A. Ezekowitz,et al.  Phagocytosis: elegant complexity. , 2005, Immunity.

[87]  A. Sher,et al.  IL-23 plays a key role in Helicobacter hepaticus–induced T cell–dependent colitis , 2006, The Journal of experimental medicine.

[88]  F. Powrie,et al.  Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation , 2006, Immunological reviews.

[89]  P. Brigidi,et al.  Prophylaxis of pouchitis onset with probiotic therapy: A double-blind, placebo-controlled trial , 2003 .

[90]  J. Genschel,et al.  Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation? , 2005, Gut.

[91]  S. Hanauer,et al.  Double blind, placebo controlled trial of metronidazole in Crohn's disease. , 1991, Gut.

[92]  Simon Heath,et al.  Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4 , 2007, PLoS genetics.

[93]  Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice , 1998, Infection and Immunity.

[94]  R. Kastelein,et al.  Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. , 2007, Annual review of immunology.

[95]  F. Powrie,et al.  Interleukin-23 drives innate and T cell–mediated intestinal inflammation , 2006, The Journal of experimental medicine.

[96]  Min Zhang,et al.  Reciprocal Cross-talk between Nod2 and TAK1 Signaling Pathways* , 2004, Journal of Biological Chemistry.

[97]  Sinead B. O'Leary,et al.  Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease , 2001, Nature Genetics.

[98]  Judy H. Cho,et al.  Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations. , 2004, Human molecular genetics.

[99]  M. Fishman,et al.  Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor , 1996, Science.

[100]  P. Mannon,et al.  Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. , 2004, The Journal of clinical investigation.