Plasma norepinephrine, epinephrine, and thyroid hormone interactions in severely burned patients.

In this prospective study of thyroid catecholamine interactions, 15 severely burned patients were divided into two groups. Nine patients receiving 200 micrograms/day of triiodothyronine constituted the T3-treated group. Eight additional patients constituted the untreated group. Mean serum concentrations of T3 were significantly lower in the untreated group than in the treated group. Mean serum thyroxine (T4) concentrations were significantly higher in the untreated group than in the treated group. The mean plasma norepinephrine concentration in the untreated group was significantly greater than that of the treated group. In the untreated group, log plasma norepinephrine correlated inversely with serum T3. Similarly, in the untreated group, log plasma epinephrine correlated inversely with serum T3. Metabolic rates were not different between groups. These data suggest that a reciprocal relationship exists between plasma concentration of T3 and both norepinephrine and epinephrine in untreated burn patients and that treatment with the metabolically active hormone, triiodothyronine, does not alter the level of hypermetabolism accompanying thermal injury.

[1]  R. Cavalieri,et al.  Impaired peripheral conversion of thyroxine to triiodothyronine,. , 1977, Annual review of medicine.

[2]  I. Kopin,et al.  Plasma noradrenaline increases with age , 1976, Nature.

[3]  L. Landsberg.  Catecholamines and the Sympathoadrenal System , 1976 .

[4]  A. Mason,et al.  Catecholamines: Znediator of the Hypermetabolic Response to Thermal Injury , 1974, Annals of surgery.

[5]  N. Christensen.  Plasma noradrenaline and adrenaline in patients with thyrotoxicosis and myxoedema. , 1973, Clinical science and molecular medicine.

[6]  C. Gorman,et al.  Plasma catecholamines in hypothyroidism and hyperthyroidism. , 1973, The Journal of clinical endocrinology and metabolism.

[7]  J. Peuler,et al.  A simplified radiometric assay for plasma norepinephrine and epinephrine. , 1973, Analytical biochemistry.

[8]  E. O. Theilen,et al.  Studies of the reputed augmentation of the cardiovascular effects of catecholamines in patients with spontaneous hyperthyroidism. , 1972, The Journal of pharmacology and experimental therapeutics.

[9]  S. K. Bisset,et al.  The correlation of thyroid function with the rate of oxygen uptake of human leucocytes. , 1961, Quarterly journal of experimental physiology and cognate medical sciences.

[10]  G. Kurland,et al.  Oxygen consumption and-thyroxine deiodination by human leukocytes. , 1960, The Journal of clinical endocrinology and metabolism.

[11]  R. W. Rawson,et al.  Modification of late radiation injury with L-triiodothyronine. , 1959, Radiology.

[12]  G. Kurland,et al.  Effect of variation in thyroid function on the pressor response to norepinephrine in man. , 1953, Metabolism: clinical and experimental.

[13]  O. Cope,et al.  Metabolic rate and thyroid function following acute thermal trauma in man. , 1953, Annals of surgery.

[14]  D. Cuthbertson,et al.  THE INFLUENCE OF METABOLIC STIMULANTS ON WOUND HEALING; THE INFLUENCE OF THYROID and 2‐4‐α DINITROPHENOL , 1944 .