Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations.
暂无分享,去创建一个
Joan Eilstein | Nicola J Hewitt | Kerstin Reisinger | Ellen Fritsche | Gladys Ouédraogo | Stefan Pfuhler | Julia Scheel | Carsten Goebel | Rolf Fautz | Claire Moore | Daniel Duche | R. Edwards | N. Hewitt | G. Ouedraogo | S. Pfuhler | C. Goebel | E. Fritsche | K. Reisinger | Jochen Kuehnl | Alain Latil | Pierre Aeby | Jochen Kuehnl | R. Fautz | C. Moore | Robert J Edwards | Julia Kenny | Joao Barroso | J. Scheel | J. Barroso | A. Latil | J. Eilstein | P. Aeby | J. Kenny | D. Duché
[1] M. Amelia,et al. Photophysical Properties and Photobiological Behavior of Amodiaquine, Primaquine and Chloroquine , 2007, Photochemistry and photobiology.
[2] H. Merk,et al. Cytochrome P450-mediated activation of the fragrance compound geraniol forms potent contact allergens. , 2008, Toxicology and applied pharmacology.
[3] Jean Krutmann,et al. Role of HuR and p38MAPK in Ultraviolet B-induced Post-transcriptional Regulation of COX-2 Expression in the Human Keratinocyte Cell Line HaCaT* , 2009, The Journal of Biological Chemistry.
[4] A. Berghard,et al. Serum and extracellular calcium modulate induction of cytochrome P-450IA1 in human keratinocytes. , 1990, The Journal of biological chemistry.
[5] R. E. Stevenson,et al. Establishment of a strain of human skin cells on chemically defined medium NCTC 109. , 1961, American journal of hygiene.
[6] J. Hornung,et al. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line , 1988, The Journal of cell biology.
[7] A. Schnuch,et al. Genetic factors in contact allergy—review and future goals , 2011, Contact dermatitis.
[8] F. Gonzalez,et al. Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. , 1994, Drug metabolism reviews.
[9] Mitchell Klausner,et al. Further development of the EpiDerm 3D reconstructed human skin micronucleus (RSMN) assay. , 2009, Mutation research.
[10] W. Lu,et al. Effect of PCB153 on BaP-induced genotoxicity in HepG2 cells via modulation of metabolic enzymes. , 2009, Mutation research.
[11] Jun Yao,et al. Cyclooxygenase-2 expression during immortalization and breast cancer progression. , 2008, Cancer research.
[12] P. G. Wells,et al. Peroxidase-dependent bioactivation and oxidation of DNA and protein in benzo[a]pyrene-initiated micronucleus formation. , 1997, Free radical biology & medicine.
[13] S. Krishnan,et al. Electrochemiluminescent arrays for cytochrome P450-activated genotoxicity screening. DNA damage from benzo[a]pyrene metabolites. , 2007, Analytical chemistry.
[14] A. Parodi,et al. A comparative study of leukaemia inhibitory factor and interleukin-1alpha intracellular content in a human keratinocyte cell line after exposure to cosmetic fragrances and sodium dodecyl sulphate. , 2010, Toxicology letters.
[15] C. Vogel. Prostaglandin H synthases and their importance in chemical toxicity. , 2000, Current drug metabolism.
[16] Nicola J Hewitt,et al. A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: skin irritation. , 2009, Regulatory toxicology and pharmacology : RTP.
[17] C. Falany,et al. Human cytosolic sulfotransferase 2B1: Isoform expression, tissue specificity and subcellular localization , 2006, The Journal of Steroid Biochemistry and Molecular Biology.
[18] D. Lewis,et al. Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size. , 2008, Toxicology in vitro : an international journal published in association with BIBRA.
[19] M. Aardema,et al. Intralaboratory and interlaboratory evaluation of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay. , 2009, Mutation research.
[20] Nicola J Hewitt,et al. International prevalidation studies of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay: transferability and reproducibility. , 2010, Mutation research.
[21] Jean Krutmann,et al. Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I): Phase I xenobiotic metabolism in human skin and in vitro skin models , 2012 .
[22] B. De Wever,et al. Predictivity of an in vitro model for acute and chronic skin irritation (SkinEthic) applied to the testing of topical vehicles , 1999, Cell Biology and Toxicology.
[23] H. Merk,et al. Cutaneous metabolic activation of carvoxime, a self-activating, skin-sensitizing prohapten. , 2009, Chemical research in toxicology.
[24] R. Edwards,et al. Elucidation of Xenobiotic Metabolism Pathways in Human Skin and Human Skin Models by Proteomic Profiling , 2012, PloS one.
[25] R L Binder,et al. Xenobiotic metabolism gene expression in the EpiDermin vitro 3D human epidermis model compared to human skin. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.
[26] Jean Krutmann,et al. Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte‐based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I) , 2012, Experimental dermatology.
[27] M. Ingelman-Sundberg,et al. Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[28] M. T. Donato,et al. Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes. , 2004, Drug metabolism and disposition: the biological fate of chemicals.
[29] S. Penco,et al. Induction by xenobiotics of phase I and phase II enzyme activities in the human keratinocyte cell line NCTC 2544. , 2001, Toxicology in vitro : an international journal published in association with BIBRA.
[30] Fernand Labrie,et al. Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin™ and full thickness model from Episkin™ , 2009, The Journal of Steroid Biochemistry and Molecular Biology.
[31] N. Hewitt,et al. Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models , 2012, Xenobiotica; the fate of foreign compounds in biological systems.
[32] Jean Krutmann,et al. Xenobiotic metabolism capacities of human skin in comparison with a 3D‐epidermis model and keratinocyte‐based cell culture as in vitro alternatives for chemical testing: phase II enzymes , 2012, Experimental dermatology.
[33] U. Yasar,et al. Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation , 2003, The Pharmacogenomics Journal.
[34] R. Edwards,et al. Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells , 2002, Xenobiotica; the fate of foreign compounds in biological systems.
[35] H. Yamazaki,et al. Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. , 1997, Drug metabolism and disposition: the biological fate of chemicals.
[36] A. Melchini,et al. Exposure of human skin to benzo[a]pyrene: role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation. , 2010, Toxicology.
[37] G. Nohynek,et al. Under the skin: Biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes. , 2005, Toxicology letters.
[38] Robert Landsiedel,et al. Drug-Metabolizing Enzymes in the Skin of Man, Rat, and Pig , 2007, Drug metabolism reviews.
[39] T. Boyer,et al. Characterization of glutathione S-transferase in cultured human keratinocytes. , 1991, The Journal of investigative dermatology.
[40] T. Iyanagi,et al. Glucuronidation of carcinogen metabolites by complementary DNA-expressed uridine 5'-diphosphate glucuronosyltransferases. , 1993, Cancer research.
[41] M. Aardema,et al. Evaluation of chemicals requiring metabolic activation in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay. , 2013, Mutation research.
[42] Yuko Higashi,et al. Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes. , 2004, The Journal of investigative dermatology.
[43] C L Galli,et al. Further development of the NCTC 2544 IL-18 assay to identify in vitro contact allergens. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.
[44] S. Hecht,et al. Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes , 2010, Drug Metabolism and Disposition.
[45] R. Weaver,et al. Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. , 1994, Biochemical pharmacology.
[46] N. Ledirac,et al. Comparative study of CYP1A1 induction by 3-methylcholanthrene in various human hepatic and epidermal cell types. , 1997, Toxicology in vitro : an international journal published in association with BIBRA.