Standard setting in occupational health: "philosophical" issues.

This paper discusses various "philosophical" issues in standard setting in occupational and environmental health, i.e., general principles, actual procedures for standard setting, inter- and intra-agency discrepancies in procedures and criteria, and choices and decisions in the preparation of criteria documents and in the evaluation of the toxicology databases. Unpublished, possibly confidential information should be made available to expert committees, workers, and the general public. There is an urgent need to improve the validity of the toxicology databases that have to underpin occupational and environmental exposure limits. Standard setting requires various ethically loaded choices and decisions by experts, employees, managers, government officials, and politicians.

[1]  R. Zielhuis,et al.  Definitions of monitoring activities and their relevance for the practice of occupational health , 1986, International archives of occupational and environmental health.

[2]  S. Rappaport Smoothing of exposure variability at the receptor: implications for health standards. , 1985, Annals of Occupational Hygiene.

[3]  V. Feron,et al.  Effects of the exposure profile on the inhalation toxicity of carbon tetrachloride in male rats , 1987, Journal of applied toxicology : JAT.

[4]  M L Dourson,et al.  Regulatory history and experimental support of uncertainty (safety) factors. , 1983, Regulatory toxicology and pharmacology : RTP.

[5]  J. Ettema,et al.  Non-auditory effects of noise in industry , 1986, International archives of occupational and environmental health.

[6]  E J Calabrese,et al.  Sex differences in susceptibility to toxic industrial chemicals. , 1986, British journal of industrial medicine.

[7]  Radiation Exposure and Levels of Occupational Safety , 1985 .

[8]  B. Castleman,et al.  Corporate influence on threshold limit values. , 1988, American journal of industrial medicine.

[9]  R. Zielhuis Biological Monitoring Studies in Occupational and Environmental Health , 1985 .

[10]  R. Sherwin,et al.  What is an adverse health effect? , 1983, Environmental health perspectives.

[11]  J. Willems Feasibility of composite workplace standards for chemical and/or physical workplace factors. , 1988, International archives of occupational and environmental health.

[12]  A. E. Robinson Standard setting and protection of human health and safety. , 1989, American journal of industrial medicine.

[13]  R. Zielhuis,et al.  Short-term occupational exposure limits: a simplified approach , 1988, International archives of occupational and environmental health.

[14]  J. Verbeek,et al.  Non-auditory effects of noise in industry , 1986, International archives of occupational and environmental health.

[15]  P. Brandt-Rauf Ethical conflict in the practice of occupational medicine. , 1989, British journal of industrial medicine.

[16]  V J Feron,et al.  Sub‐acute versus sub‐chronic oral toxicity study in rats: Comparative study of 82 compounds , 1984, Journal of applied toxicology : JAT.

[17]  G. Atherley A critical review of time-weighted average as an index of exposure and dose, and of its key elements. , 1985, American Industrial Hygiene Association journal.

[18]  T. Hatch,et al.  Changing objectives in occupational health. , 1962, American Industrial Hygiene Association journal.

[19]  F J van Dijk,et al.  Towards a dynamic model of exposure, susceptibility and effect. , 1988, International archives of occupational and environmental health.

[20]  R. Herber,et al.  Health Surveillance of Individual Workers Exposed to Chemical Agents , 1988, International Archives of Occupational and Environmental Health Supplement.

[21]  R. Naeye,et al.  Working during pregnancy: effects on the fetus. , 1982, Pediatrics.

[22]  Zielhuis Rl Biological monitoring. Guest lecture given at the 26th Nordic symposium on industrial hygiene, Helsinki, October 1977. , 1978 .

[23]  R. L. Zielhuis Biological exposure limits: the fetus and EEC politics. , 1985, British journal of industrial medicine.

[24]  D. Henschler Exposure limits: history, philosophy, future developments. , 1984, The Annals of occupational hygiene.

[25]  I W Davidson,et al.  Biological basis for extrapolation across mammalian species. , 1986, Regulatory toxicology and pharmacology : RTP.

[26]  R. Zielhuis,et al.  Permissible levels for occupational exposure; Basic concepts , 1979, International archives of occupational and environmental health.

[27]  T. Hatch Significant dimensions of the dose-response relationship. , 1968, Archives of environmental health.

[28]  R. Zielhuis Biological quality guide for inorganic lead , 1974, Internationales Archiv fur Arbeitsmedizin.

[29]  R. Zielhuis Standards for chemical quality of drinking water: A critical assessment , 1982, International archives of occupational and environmental health.

[30]  E. W. van Stee,et al.  Time-varying concentration profile as a determinant of the inhalation toxicity of carbon tetrachloride. , 1982, Journal of toxicology and environmental health.