The management of melanoma and nonmelanoma skin cancer: a review for the primary care physician.

In the United States, the incidence of skin cancer is greater than that of all other cancers combined, and early diagnosis can be lifesaving. A substantial public health concern, skin cancer is increasingly being diagnosed and managed by primary care physicians. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) (known collectively as nonmelanoma skin cancer) and malignant melanoma are the most common cutaneous malignancies. Shave biopsy is usually performed if BCC is suspected; punch biopsy is preferred if SCC is thought to be present. The choice of biopsy techniques depends on the presumed depth of the lesion. Treatment has 3 goals: complete eradication of the cancer and preservation or restoration of normal function and cosmesis. Risk of recurrence or metastasis determines whether the tumor is high risk or low risk. Based on the level of risk, treatment options are considered, including whether the patient can be treated by a primary care physician or should be referred to a dermatologist. Choice of treatment approach depends on the tumor's location, size, borders, and growth rate. The standard treatment approaches are superficial ablative techniques (electro-desiccation and curettage and cryotherapy) used primarily for low-risk tumors and full-thickness techniques (Mohs micrographic surgery, excisional surgery, and radiotherapy) used to treat high-risk tumors. Removal of the entire tumor is essential to limit and prevent tumor recurrence.

[1]  N. Swanson,et al.  Squamous cell carcinoma of the skin (excluding lip and oral mucosa). , 1992, Journal of the American Academy of Dermatology.

[2]  B. Nelson,et al.  Current therapy of cutaneous melanoma. , 1996, Cutis.

[3]  C. Chute,et al.  Squamous Cell Carcinoma: A Population-Based Incidence Study in Rochester, Minn , 1990 .

[4]  C. Otley,et al.  Review of Sentinel Lymph Node Biopsy and Systemic Interferon for Melanoma: Promising but Investigational Modalities , 2000, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[5]  M. Pittelkow,et al.  Skin cancer in liver transplant recipients , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[6]  J. Zitelli,et al.  Mohs micrographic surgery: a cost analysis. , 1998, Journal of the American Academy of Dermatology.

[7]  J. Kirkwood,et al.  Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[8]  C. Kim-sing,et al.  Radiotherapy in the treatment of dermatologic malignancies. , 1998, Dermatologic clinics.

[9]  H. Kittler,et al.  Follow-up of melanocytic skin lesions with digital epiluminescence microscopy: patterns of modifications observed in early melanoma, atypical nevi, and common nevi. , 2000, Journal of the American Academy of Dermatology.

[10]  B. Nelson,et al.  Mohs' micrographic surgery for nonmelanoma skin cancers. , 1997, Clinics in plastic surgery.

[11]  N. Swanson,et al.  Concepts of sliding and lifting tissue movement in flap reconstruction. , 2000, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[12]  Graham Gf Advances in cryosurgery during the past decade. , 1993 .

[13]  J. Lang,et al.  Histologic evolution of recurrent basal cell carcinoma and treatment implications. , 1986, Journal of the American Academy of Dermatology.

[14]  C. Cockerell Biopsy technique for pigmented lesions. , 1997, Seminars in cutaneous medicine and surgery.

[15]  A. Kopf,et al.  Multivariate risk score for recurrence of cutaneous basal cell carcinomas. , 1983, Archives of dermatology.

[16]  C. Grin,et al.  Recurrence rates of treated basal cell carcinomas. Part 2: Curettage-electrodesiccation. , 1991, The Journal of dermatologic surgery and oncology.

[17]  K L Garner,et al.  Basal and squamous cell carcinoma. , 2000, Primary care.

[18]  N. Swanson Mohs surgery. Technique, indications, applications, and the future. , 1983, Archives of dermatology.

[19]  R. Weber,et al.  Frozen section analysis in the management of skin cancers. , 1999, Annals of plastic surgery.

[20]  A. Sober,et al.  Ultra‐late recurrence (15 years or longer) of cutaneous melanoma , 1997, Cancer.

[21]  R. Carroll,et al.  Long-term recurrence rates in previously untreated (primary) basal cell carcinoma: implications for patient follow-up. , 1989, The Journal of dermatologic surgery and oncology.

[22]  Martin F. Mihm,et al.  A new American Joint Committee on Cancer staging system for cutaneous melanoma , 2000, Cancer.

[23]  S. Stegman Basal cell carcinoma and squamous cell carcinoma. Recognition and treatment. , 1986, The Medical clinics of North America.

[24]  R. Moy,et al.  The reliability of frozen sections in the evaluation of surgical margins for melanoma. , 1991, Journal of the American Academy of Dermatology.

[25]  R. Carroll,et al.  Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. , 1992, Journal of the American Academy of Dermatology.

[26]  E. G. Kuflik Cryosurgery for Cutaneous Malignancy An Update , 1997, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[27]  D. Rowe Comparison of treatment modalities for basal cell carcinoma. , 1995, Clinics in dermatology.

[28]  P. J. August Cryotherapy of nonmelanoma skin cancer. , 1995, Clinics in dermatology.

[29]  R. Kaufmann Surgical management of primary melanoma , 2000, Clinical and experimental dermatology.

[30]  N. Levine,et al.  Role of retinoids in skin cancer treatment and prevention. , 1998, Journal of the American Academy of Dermatology.

[31]  Barlow,et al.  The role of photodynamic therapy in dermatology , 1999, Clinical and experimental dermatology.

[32]  N. Cascinelli,et al.  Narrow excision (1-cm margin). A safe procedure for thin cutaneous melanoma. , 1991, Archives of surgery.

[33]  Gary S. Rogers,et al.  Diagnosis and Treatment of Early Melanoma: NIH Consensus Development Panel on Early Melanoma , 1992 .

[34]  Jeffrey E. Lee,et al.  Role for Lymphatic Mapping and Sentinel Lymph Node Biopsy in Patients With Thick (≥4 mm) Primary Melanoma , 2000, Annals of Surgical Oncology.

[35]  A. Sober,et al.  Computerized Digital Image Analysis: An Aid for Melanoma Diagnosis , 1994, The Journal of dermatology.

[36]  K. Arndt,et al.  Cutaneous Medicine and Surgery: An Integrated Program in Dermatology , 1996 .

[37]  J. O'fallon,et al.  Utility of follow-up tests for detecting recurrent disease in patients with malignant melanomas. , 1995, JAMA.

[38]  D. Rigel,et al.  Malignant melanoma: Prevention, early detection, and treatment in the 21st century , 2000, CA: a cancer journal for clinicians.

[39]  T. Barrett,et al.  Recognition and management of high-risk cutaneous tumors. , 1999, Dermatologic clinics.

[40]  R. Grekin,et al.  Cancer of the forehead and temple regions. , 1989, Dermatologic clinics.

[41]  I. Fleming,et al.  Principles of management of basal and squamous cell carcinoma of the skin , 1995, Cancer.

[42]  R. Stern,et al.  Nonmelanoma cancers of the skin. , 1992, The New England journal of medicine.

[43]  J. Spellman,et al.  Role of sentinel node biopsy in the management of malignant melanoma. , 1996, Oncology.

[44]  E. R. Farmer,et al.  NIH Consensus conference. Diagnosis and treatment of early melanoma. , 1992, JAMA.

[45]  B. Hanusa,et al.  Mohs micrographic surgery for the treatment of primary cutaneous melanoma. , 1997, Journal of the American Academy of Dermatology.

[46]  R. Carroll,et al.  Mohs surgery is the treatment of choice for recurrent (previously treated) basal cell carcinoma. , 1989, The Journal of dermatologic surgery and oncology.

[47]  S. Miller,et al.  The National Comprehensive Cancer Network (NCCN) guidelines of care for nonmelanoma skin cancers. , 2000, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[48]  M. Ross,et al.  The Orderly Progression of Melanoma Nodal Metastases , 1994, Annals of surgery.

[49]  D. Brodland,et al.  Overview of skin cancer detection and prevention for the primary care physician. , 2000, Mayo Clinic proceedings.

[50]  M. Kashani-Sabet Toward the biologic treatment of nonmelanoma skin cancer. , 1999, Journal of the American Academy of Dermatology.

[51]  W. White,et al.  Sentinel lymphadenectomy in the management of primary cutaneous malignant melanoma. An update. , 1999, Dermatologic clinics.

[52]  A. Kayıkçıoğlu,et al.  The effect of onlay Medpor implants on mandibular growth in young rabbits: an experimental study. , 1999, Annals of plastic surgery.

[53]  D. Brodland,et al.  The Epidemiology of Skin Cancer , 1996, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].