Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues
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[1] Jimeng Sun,et al. Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later , 2021, Genome medicine.
[2] R. Keivabu. Robert Plomin: Blueprint: How DNA Makes Us Who We Are , 2020 .
[3] David S Jones,et al. Hidden in Plain Sight - Reconsidering the Use of Race Correction in Clinical Algorithms. , 2020, The New England journal of medicine.
[4] E. Vassos,et al. Polygenic risk scores: from research tools to clinical instruments , 2020, Genome Medicine.
[5] A. Scally,et al. What is ancestry? , 2020, PLoS genetics.
[6] C. Robinson-Cohen,et al. Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease. , 2020, JAMA.
[7] P. Elliott,et al. Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease. , 2020, JAMA.
[8] A. McGee. Using the Therapy and Enhancement Distinction in Law and Policy , 2020, Bioethics.
[9] A. Kong,et al. Deconstructing the sources of genotype-phenotype associations in humans , 2019, Science.
[10] Nicole A. Restrepo,et al. Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems. , 2019, The American journal of psychiatry.
[11] A. Philippakis,et al. The "All of Us" Research Program. , 2019, The New England journal of medicine.
[12] J. Gray,et al. Screening: Evidence and Practice , 2019 .
[13] Alicia R. Martin,et al. Predicting Polygenic Risk of Psychiatric Disorders , 2019, Biological Psychiatry.
[14] W. Chung,et al. Psychological outcomes related to exome and genome sequencing result disclosure: a meta-analysis of seven Clinical Sequencing Exploratory Research (CSER) Consortium studies , 2019, Genetics in Medicine.
[15] J. Pritchard,et al. Variable prediction accuracy of polygenic scores within an ancestry group , 2019, bioRxiv.
[16] L. Kruglyak,et al. Screening Human Embryos for Polygenic Traits Has Limited Utility , 2019, Cell.
[17] J. Roberts,et al. Assessing the Psychological Impact of Genetic Susceptibility Testing. , 2019, The Hastings Center report.
[18] Matthew S. Lebo,et al. Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood , 2019, Cell.
[19] Alicia R. Martin,et al. Clinical use of current polygenic risk scores may exacerbate health disparities , 2019, Nature Genetics.
[20] Lauren Stewart,et al. Genetics for all , 2019, Nature Genetics.
[21] W. Chung,et al. Rethinking the “Open Future” Argument against Predictive Genetic Testing of Children , 2019, Genetics in Medicine.
[22] Brian A. Gordon,et al. Assessment of Racial Disparities in Biomarkers for Alzheimer Disease , 2019, JAMA neurology.
[23] L. Wolf,et al. The Web of Legal Protections for Participants in Genomic Research. , 2019, Health matrix.
[24] R. Marioni,et al. Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions , 2019, Nature Neuroscience.
[25] N. Wald,et al. The illusion of polygenic disease risk prediction , 2019, Genetics in Medicine.
[26] B. Knoppers,et al. Return of individual genomic research results: are laws and policies keeping step? , 2019, European Journal of Human Genetics.
[27] R. Green,et al. Returning a Genomic Result for an Adult-Onset Condition to the Parents of a Newborn: Insights From the BabySeq Project , 2019, Pediatrics.
[28] A. Malhotra,et al. Schizophrenia Polygenic Risk Score as a Predictor of Antipsychotic Efficacy in First-Episode Psychosis. , 2019, The American journal of psychiatry.
[29] G. Pravettoni,et al. A Systematic Review of the Psychological Implications of Genetic Testing: A Comparative Analysis Among Cardiovascular, Neurodegenerative and Cancer Diseases , 2018, Front. Genet..
[30] Dan J Stein,et al. Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk , 2018, Philosophy, Ethics, and Humanities in Medicine.
[31] A. Butte,et al. Comparing Ethnicity-Specific Reference Intervals for Clinical Laboratory Tests from EHR Data. , 2018, The journal of applied laboratory medicine.
[32] G. Gibson. Going to the negative: genomics for optimized medical prescription , 2018, Nature reviews genetics.
[33] S. Vrieze,et al. Behavioral Impact of Return of Genetic Test Results for Complex Disease: Systematic Review and Meta-Analysis , 2018, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.
[34] Matthew Warren,et al. The approach to predictive medicine that is taking genomics research by storm , 2018, Nature.
[35] J. Danesh,et al. Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults , 2018, Journal of the American College of Cardiology.
[36] Sandro Galea,et al. "Precision" Public Health - Between Novelty and Hype. , 2018, The New England journal of medicine.
[37] R. Green,et al. Parental Interest in Genomic Sequencing of Newborns: Enrollment Experience from the BabySeq Project , 2018, Genetics in Medicine.
[38] Mary E. Haas,et al. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations , 2018, Nature Genetics.
[39] G. Ruaño,et al. Preventing the exacerbation of health disparities by iatrogenic pharmacogenomic applications: lessons from warfarin. , 2018, Pharmacogenomics.
[40] C. Lewis,et al. Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: Meta-analysis of three treatment cohorts , 2018, bioRxiv.
[41] Marian J. Gilmore,et al. Why Patients Decline Genomic Sequencing Studies: Experiences from the CSER Consortium , 2018, Journal of Genetic Counseling.
[42] R. Erasmus,et al. Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans: a cross sectional study , 2017, BMC Nephrology.
[43] Bjarni V. Halldórsson,et al. The nature of nurture: Effects of parental genotypes , 2017, Science.
[44] A. Prince. Insurance Risk Classification in an Era of Genomics: Is a Rational Discrimination Policy Rational? , 2017, Nebraska law review.
[45] E. Ziv,et al. The WISDOM Study: breaking the deadlock in the breast cancer screening debate , 2017, npj Breast Cancer.
[46] M. Zeegers,et al. Behavioural changes, sharing behaviour and psychological responses after receiving direct-to-consumer genetic test results: a systematic review and meta-analysis , 2017, Journal of Community Genetics.
[47] C. Egan,et al. Research Program , 2017, Research quarterly for exercise and sport.
[48] Sarah M. Hartz,et al. Implications of Personal Genomic Testing for Health Behaviors: The Case of Smoking. , 2016, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.
[49] D. Bouk. Risky Medicine: Our Quest to Cure Fear and Uncertainty. , 2016, International journal of epidemiology.
[50] Michael J. Keiser,et al. Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach. , 2016, The lancet. Psychiatry.
[51] Andreas Reis,et al. Public Health Ethics: Global Cases, Practice, and Context -- Public Health Ethics: Cases Spanning the Globe , 2016 .
[52] T. Marteau,et al. The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis , 2016, British Medical Journal.
[53] R. Green,et al. Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial). , 2016, Circulation.
[54] Denise L. Perry,et al. Participants and Study Decliners’ Perspectives About the Risks of Participating in a Clinical Trial of Whole Genome Sequencing , 2016, Journal of empirical research on human research ethics : JERHRE.
[55] H. D. den Ruijter,et al. The ethnicity-specific association of biomarkers with the angiographic severity of coronary artery disease , 2016, Netherlands Heart Journal.
[56] A. Patenaude,et al. The psychological impact of genetic information on children: a systematic review , 2016, Genetics in Medicine.
[57] S. Suter. The problems of liminal states, line drawing, and false dichotomies , 2015, Journal of law and the biosciences.
[58] R. Aronowitz. Risky Medicine: Our Quest to Cure Fear and Uncertainty , 2015 .
[59] Jane E. Carpenter,et al. Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants , 2015, JNCI Journal of the National Cancer Institute.
[60] Robert C Green,et al. GINA, genetic discrimination, and genomic medicine. , 2015, The New England journal of medicine.
[61] R. Green,et al. 'Someday it will be the norm': physician perspectives on the utility of genome sequencing for patient care in the MedSeq Project. , 2015, Personalized medicine.
[62] P. Glasziou,et al. Communicating cardiovascular disease risk: an interview study of General Practitioners’ use of absolute risk within tailored communication strategies , 2014, BMC Family Practice.
[63] Nicole L. Exe,et al. Animated Randomness, Avatars, Movement, and Personalization in Risk Graphics , 2014, Journal of medical Internet research.
[64] D. Roberts. Law, Race, and Biotechnology: Toward a Biopolitical and Transdisciplinary Paradigm , 2013 .
[65] R. Santos,et al. Relevance of prehypertension as a diagnostic category in asymptomatic adults , 2013, Einstein.
[66] B. Knoppers,et al. Recommendations for returning genomic incidental findings? We need to talk! , 2013, Genetics in Medicine.
[67] Marc S. Williams,et al. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing , 2013, Genetics in Medicine.
[68] L. Afonso,et al. Association of novel biomarkers with future cardiovascular events is influenced by ethnicity: results from a multi-ethnic cohort. , 2013, International journal of cardiology.
[69] P. Hall,et al. Incorporating genomics into breast and prostate cancer screening: assessing the implications , 2013, Genetics in Medicine.
[70] A. Bleyer,et al. Effect of three decades of screening mammography on breast-cancer incidence. , 2012, The New England journal of medicine.
[71] S. Fullerton,et al. What Are Our AIMs? Interdisciplinary Perspectives on the Use of Ancestry Estimation in Disease Research , 2012, AJOB primary research.
[72] E. Juengst,et al. Personalized genomic medicine and the rhetoric of empowerment. , 2012, The Hastings Center report.
[73] Muin J Khoury,et al. A population approach to precision medicine. , 2012, American journal of preventive medicine.
[74] G. Kalyanaram,et al. Nudge: Improving Decisions about Health, Wealth, and Happiness , 2011 .
[75] Gabriella Pravettoni,et al. A P5 cancer medicine approach: why personalized medicine cannot ignore psychology. , 2011, Journal of evaluation in clinical practice.
[76] V. Moyer,et al. Reconsidering the criteria for evaluating proposed screening programs: reflections from 4 current and former members of the U.S. Preventive services task force. , 2011, Epidemiologic reviews.
[77] M. Rietschel,et al. Dissecting the phenotype in genome-wide association studies of psychiatric illness , 2009, British Journal of Psychiatry.
[78] N. Rose,et al. Biomarkers in psychiatry , 2009, Nature.
[79] Robert Cook-Deegan,et al. Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience , 2008, Genetics in Medicine.
[80] M. Spillman,et al. Managing familial risk in genetic testing. , 2004, Genetic testing.
[81] C. T. Salmon,et al. Guilt, fear, stigma and knowledge gaps: ethical issues in public health communication interventions. , 2004, Bioethics.
[82] Karl Atkin,et al. Why ethnic minority groups are under-represented in clinical trials: a review of the literature. , 2004, Health & social care in the community.
[83] Celeste M Condit,et al. Genetic research and health disparities. , 2004, JAMA.
[84] B. Godard,et al. Population genetic screening programmes: principles, techniques, practices, and policies , 2003, European Journal of Human Genetics.
[85] E. Clayton. Ethical, legal, and social implications of genomic medicine. , 2003, The New England journal of medicine.
[86] Daniel Wikler,et al. Personal and Social Responsibility for Health , 2002, Ethics & International Affairs.
[87] G Rose,et al. Sick individuals and sick populations. , 1985, International journal of epidemiology.
[88] D. Falconer. The inheritance of liability to certain diseases, estimated from the incidence among relatives , 1965 .
[89] M. Rutter,et al. Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults Implications for Primary Prevention , 2019 .
[90] Oguzhan Alagoz,et al. Concepts of ‘Personalization’ in Personalized Medicine: Implications for Economic Evaluation , 2014, PharmacoEconomics.
[91] Candace Timpte,et al. The Genetic Information Nondiscrimination Act , 2013 .
[92] Don McCarthy. Ethics of Manipulation , 1977, Ethics & Medics.