Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues

[1]  Jimeng Sun,et al.  Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later , 2021, Genome medicine.

[2]  R. Keivabu Robert Plomin: Blueprint: How DNA Makes Us Who We Are , 2020 .

[3]  David S Jones,et al.  Hidden in Plain Sight - Reconsidering the Use of Race Correction in Clinical Algorithms. , 2020, The New England journal of medicine.

[4]  E. Vassos,et al.  Polygenic risk scores: from research tools to clinical instruments , 2020, Genome Medicine.

[5]  A. Scally,et al.  What is ancestry? , 2020, PLoS genetics.

[6]  C. Robinson-Cohen,et al.  Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease. , 2020, JAMA.

[7]  P. Elliott,et al.  Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease. , 2020, JAMA.

[8]  A. McGee Using the Therapy and Enhancement Distinction in Law and Policy , 2020, Bioethics.

[9]  A. Kong,et al.  Deconstructing the sources of genotype-phenotype associations in humans , 2019, Science.

[10]  Nicole A. Restrepo,et al.  Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems. , 2019, The American journal of psychiatry.

[11]  A. Philippakis,et al.  The "All of Us" Research Program. , 2019, The New England journal of medicine.

[12]  J. Gray,et al.  Screening: Evidence and Practice , 2019 .

[13]  Alicia R. Martin,et al.  Predicting Polygenic Risk of Psychiatric Disorders , 2019, Biological Psychiatry.

[14]  W. Chung,et al.  Psychological outcomes related to exome and genome sequencing result disclosure: a meta-analysis of seven Clinical Sequencing Exploratory Research (CSER) Consortium studies , 2019, Genetics in Medicine.

[15]  J. Pritchard,et al.  Variable prediction accuracy of polygenic scores within an ancestry group , 2019, bioRxiv.

[16]  L. Kruglyak,et al.  Screening Human Embryos for Polygenic Traits Has Limited Utility , 2019, Cell.

[17]  J. Roberts,et al.  Assessing the Psychological Impact of Genetic Susceptibility Testing. , 2019, The Hastings Center report.

[18]  Matthew S. Lebo,et al.  Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood , 2019, Cell.

[19]  Alicia R. Martin,et al.  Clinical use of current polygenic risk scores may exacerbate health disparities , 2019, Nature Genetics.

[20]  Lauren Stewart,et al.  Genetics for all , 2019, Nature Genetics.

[21]  W. Chung,et al.  Rethinking the “Open Future” Argument against Predictive Genetic Testing of Children , 2019, Genetics in Medicine.

[22]  Brian A. Gordon,et al.  Assessment of Racial Disparities in Biomarkers for Alzheimer Disease , 2019, JAMA neurology.

[23]  L. Wolf,et al.  The Web of Legal Protections for Participants in Genomic Research. , 2019, Health matrix.

[24]  R. Marioni,et al.  Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions , 2019, Nature Neuroscience.

[25]  N. Wald,et al.  The illusion of polygenic disease risk prediction , 2019, Genetics in Medicine.

[26]  B. Knoppers,et al.  Return of individual genomic research results: are laws and policies keeping step? , 2019, European Journal of Human Genetics.

[27]  R. Green,et al.  Returning a Genomic Result for an Adult-Onset Condition to the Parents of a Newborn: Insights From the BabySeq Project , 2019, Pediatrics.

[28]  A. Malhotra,et al.  Schizophrenia Polygenic Risk Score as a Predictor of Antipsychotic Efficacy in First-Episode Psychosis. , 2019, The American journal of psychiatry.

[29]  G. Pravettoni,et al.  A Systematic Review of the Psychological Implications of Genetic Testing: A Comparative Analysis Among Cardiovascular, Neurodegenerative and Cancer Diseases , 2018, Front. Genet..

[30]  Dan J Stein,et al.  Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk , 2018, Philosophy, Ethics, and Humanities in Medicine.

[31]  A. Butte,et al.  Comparing Ethnicity-Specific Reference Intervals for Clinical Laboratory Tests from EHR Data. , 2018, The journal of applied laboratory medicine.

[32]  G. Gibson Going to the negative: genomics for optimized medical prescription , 2018, Nature reviews genetics.

[33]  S. Vrieze,et al.  Behavioral Impact of Return of Genetic Test Results for Complex Disease: Systematic Review and Meta-Analysis , 2018, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[34]  Matthew Warren,et al.  The approach to predictive medicine that is taking genomics research by storm , 2018, Nature.

[35]  J. Danesh,et al.  Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults , 2018, Journal of the American College of Cardiology.

[36]  Sandro Galea,et al.  "Precision" Public Health - Between Novelty and Hype. , 2018, The New England journal of medicine.

[37]  R. Green,et al.  Parental Interest in Genomic Sequencing of Newborns: Enrollment Experience from the BabySeq Project , 2018, Genetics in Medicine.

[38]  Mary E. Haas,et al.  Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations , 2018, Nature Genetics.

[39]  G. Ruaño,et al.  Preventing the exacerbation of health disparities by iatrogenic pharmacogenomic applications: lessons from warfarin. , 2018, Pharmacogenomics.

[40]  C. Lewis,et al.  Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: Meta-analysis of three treatment cohorts , 2018, bioRxiv.

[41]  Marian J. Gilmore,et al.  Why Patients Decline Genomic Sequencing Studies: Experiences from the CSER Consortium , 2018, Journal of Genetic Counseling.

[42]  R. Erasmus,et al.  Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans: a cross sectional study , 2017, BMC Nephrology.

[43]  Bjarni V. Halldórsson,et al.  The nature of nurture: Effects of parental genotypes , 2017, Science.

[44]  A. Prince Insurance Risk Classification in an Era of Genomics: Is a Rational Discrimination Policy Rational? , 2017, Nebraska law review.

[45]  E. Ziv,et al.  The WISDOM Study: breaking the deadlock in the breast cancer screening debate , 2017, npj Breast Cancer.

[46]  M. Zeegers,et al.  Behavioural changes, sharing behaviour and psychological responses after receiving direct-to-consumer genetic test results: a systematic review and meta-analysis , 2017, Journal of Community Genetics.

[47]  C. Egan,et al.  Research Program , 2017, Research quarterly for exercise and sport.

[48]  Sarah M. Hartz,et al.  Implications of Personal Genomic Testing for Health Behaviors: The Case of Smoking. , 2016, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[49]  D. Bouk Risky Medicine: Our Quest to Cure Fear and Uncertainty. , 2016, International journal of epidemiology.

[50]  Michael J. Keiser,et al.  Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach. , 2016, The lancet. Psychiatry.

[51]  Andreas Reis,et al.  Public Health Ethics: Global Cases, Practice, and Context -- Public Health Ethics: Cases Spanning the Globe , 2016 .

[52]  T. Marteau,et al.  The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis , 2016, British Medical Journal.

[53]  R. Green,et al.  Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial). , 2016, Circulation.

[54]  Denise L. Perry,et al.  Participants and Study Decliners’ Perspectives About the Risks of Participating in a Clinical Trial of Whole Genome Sequencing , 2016, Journal of empirical research on human research ethics : JERHRE.

[55]  H. D. den Ruijter,et al.  The ethnicity-specific association of biomarkers with the angiographic severity of coronary artery disease , 2016, Netherlands Heart Journal.

[56]  A. Patenaude,et al.  The psychological impact of genetic information on children: a systematic review , 2016, Genetics in Medicine.

[57]  S. Suter The problems of liminal states, line drawing, and false dichotomies , 2015, Journal of law and the biosciences.

[58]  R. Aronowitz Risky Medicine: Our Quest to Cure Fear and Uncertainty , 2015 .

[59]  Jane E. Carpenter,et al.  Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants , 2015, JNCI Journal of the National Cancer Institute.

[60]  Robert C Green,et al.  GINA, genetic discrimination, and genomic medicine. , 2015, The New England journal of medicine.

[61]  R. Green,et al.  'Someday it will be the norm': physician perspectives on the utility of genome sequencing for patient care in the MedSeq Project. , 2015, Personalized medicine.

[62]  P. Glasziou,et al.  Communicating cardiovascular disease risk: an interview study of General Practitioners’ use of absolute risk within tailored communication strategies , 2014, BMC Family Practice.

[63]  Nicole L. Exe,et al.  Animated Randomness, Avatars, Movement, and Personalization in Risk Graphics , 2014, Journal of medical Internet research.

[64]  D. Roberts Law, Race, and Biotechnology: Toward a Biopolitical and Transdisciplinary Paradigm , 2013 .

[65]  R. Santos,et al.  Relevance of prehypertension as a diagnostic category in asymptomatic adults , 2013, Einstein.

[66]  B. Knoppers,et al.  Recommendations for returning genomic incidental findings? We need to talk! , 2013, Genetics in Medicine.

[67]  Marc S. Williams,et al.  ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing , 2013, Genetics in Medicine.

[68]  L. Afonso,et al.  Association of novel biomarkers with future cardiovascular events is influenced by ethnicity: results from a multi-ethnic cohort. , 2013, International journal of cardiology.

[69]  P. Hall,et al.  Incorporating genomics into breast and prostate cancer screening: assessing the implications , 2013, Genetics in Medicine.

[70]  A. Bleyer,et al.  Effect of three decades of screening mammography on breast-cancer incidence. , 2012, The New England journal of medicine.

[71]  S. Fullerton,et al.  What Are Our AIMs? Interdisciplinary Perspectives on the Use of Ancestry Estimation in Disease Research , 2012, AJOB primary research.

[72]  E. Juengst,et al.  Personalized genomic medicine and the rhetoric of empowerment. , 2012, The Hastings Center report.

[73]  Muin J Khoury,et al.  A population approach to precision medicine. , 2012, American journal of preventive medicine.

[74]  G. Kalyanaram,et al.  Nudge: Improving Decisions about Health, Wealth, and Happiness , 2011 .

[75]  Gabriella Pravettoni,et al.  A P5 cancer medicine approach: why personalized medicine cannot ignore psychology. , 2011, Journal of evaluation in clinical practice.

[76]  V. Moyer,et al.  Reconsidering the criteria for evaluating proposed screening programs: reflections from 4 current and former members of the U.S. Preventive services task force. , 2011, Epidemiologic reviews.

[77]  M. Rietschel,et al.  Dissecting the phenotype in genome-wide association studies of psychiatric illness , 2009, British Journal of Psychiatry.

[78]  N. Rose,et al.  Biomarkers in psychiatry , 2009, Nature.

[79]  Robert Cook-Deegan,et al.  Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience , 2008, Genetics in Medicine.

[80]  M. Spillman,et al.  Managing familial risk in genetic testing. , 2004, Genetic testing.

[81]  C. T. Salmon,et al.  Guilt, fear, stigma and knowledge gaps: ethical issues in public health communication interventions. , 2004, Bioethics.

[82]  Karl Atkin,et al.  Why ethnic minority groups are under-represented in clinical trials: a review of the literature. , 2004, Health & social care in the community.

[83]  Celeste M Condit,et al.  Genetic research and health disparities. , 2004, JAMA.

[84]  B. Godard,et al.  Population genetic screening programmes: principles, techniques, practices, and policies , 2003, European Journal of Human Genetics.

[85]  E. Clayton Ethical, legal, and social implications of genomic medicine. , 2003, The New England journal of medicine.

[86]  Daniel Wikler,et al.  Personal and Social Responsibility for Health , 2002, Ethics & International Affairs.

[87]  G Rose,et al.  Sick individuals and sick populations. , 1985, International journal of epidemiology.

[88]  D. Falconer The inheritance of liability to certain diseases, estimated from the incidence among relatives , 1965 .

[89]  M. Rutter,et al.  Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults Implications for Primary Prevention , 2019 .

[90]  Oguzhan Alagoz,et al.  Concepts of ‘Personalization’ in Personalized Medicine: Implications for Economic Evaluation , 2014, PharmacoEconomics.

[91]  Candace Timpte,et al.  The Genetic Information Nondiscrimination Act , 2013 .

[92]  Don McCarthy Ethics of Manipulation , 1977, Ethics & Medics.