论文信息 - Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human estrogen receptor β locus

Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human estrogen receptor β locus

AbstractA gene for a second type of human estrogen receptor, the estrogen receptor β (ESRβ), was recently identified. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing the human estrogen receptor β gene. High heterozygosity (0.93) makes this polymorphism a useful marker in the genetic study of disorders affecting female endocrine systems; calcium metabolism; and breast, uterine, and ovarian cancers.

[1] J. Polman,et al. ERβ: Identification and characterization of a novel human estrogen receptor , 1996 .

[2] T. Yanase. Human genetics: Past, present, and future, with special reference to major trends in Japan , 1997, Japanese Journal of Human Genetics.

[3] K. Lange,et al. Statistical methods for multipoint radiation hybrid mapping. , 1991, American journal of human genetics.

[4] Yusuke Nakamura. Application of DNA markers to clinical genetics , 1996, Japanese Journal of Human Genetics.

[5] J. Polman,et al. ER beta: identification and characterization of a novel human estrogen receptor. , 1996, FEBS letters.

[6] T. Ogihara,et al. Six dinucleotide repeat polymorphisms on chromosome 7 , 1994, Japanese Journal of Human Genetics.