A Microwave and Microfluidic Planar Resonator for Efficient and Accurate Complex Permittivity Characterization of Aqueous Solutions

A microwave resonator is presented as a microfabricated sensor dedicated to liquid characterization with perspectives for chemistry and biology. The nanolitter range aqueous solution under investigation is located on top of the planar resonator thanks to a microfluidic channel compatible with a future lab-on-a-chip integration. The interaction between the electric field and the liquid translates into a predictable relationship between electrical characteristics of the resonator (resonant frequency and associated insertion loss) and the complex permittivity of the fluid (real and imaginary parts). A prototype of the resonator has been fabricated and evaluated with de-ionized water/ethanol mixtures with ethanol volume fraction ranging from 0% to 20%. Good agreement has been reached between theoretical and measured electrical parameters of the resonator. The discrepancy on the resonant frequency is estimated to 0.5%, whereas the one on the associated transmission coefficient is lower than 1%. This translates into a maximum relative error on the real and imaginary part of the predicted relative permittivity of less than 6.5% and 4%, respectively, validating the principle of this accurate permittivity characterization methodology.

[1]  Yong-Jun Kim,et al.  A novel relative humidity sensor based on microwave resonators and a customized polymeric film , 2006 .

[2]  T. E. Hodgetts,et al.  Dielectric measurements on reference liquids using automatic network analysers and calculable geometries , 1990 .

[3]  Changjun Liu,et al.  A Microstrip Resonator With Slotted Ground Plane for Complex Permittivity Measurements of Liquids , 2008, IEEE Microwave and Wireless Components Letters.

[4]  Jose M. Catala-Civera,et al.  Accurate determination of the complex permittivity of materials with transmission reflection measurements in partially filled rectangular waveguides , 2003 .

[5]  Kiejin Lee,et al.  Microwave dielectric resonator biosensor for aqueous glucose solution. , 2008, The Review of scientific instruments.

[6]  Abbas Omar,et al.  Accurate Microwave Resonant Method for Complex Permittivity Measurements of Liquids , 2000 .

[7]  M. Afsar,et al.  MEASUREMENT OF COMPLEX PERMITTIVITY OF LIQUIDS USING WAVEGUIDE TECHNIQUES , 2003 .

[8]  Christopher C. Davis,et al.  Microwave dielectric characterization of binary mixtures of water, methanol, and ethanol , 1996 .

[9]  A. Waggoner,et al.  Molecular mechanism controlling the incorporation of fluorescent nucleotides into DNA by PCR. , 1997, Cytometry.

[10]  S. Knuutila,et al.  Comparison of fluorescein isothiocyanate- and Texas red-conjugated nucleotides for direct labeling in comparative genomic hybridization. , 1998, Cytometry.

[11]  T. Fujii,et al.  Integrated Broadband Microwave and Microfluidic Sensor Dedicated to Bioengineering , 2009, IEEE Transactions on Microwave Theory and Techniques.

[12]  Y. Kobayashi,et al.  Accurate measurements of complex permittivity of liquid based on a TM/sub 010/ mode cylindrical cavity method , 2005, 2005 European Microwave Conference.

[13]  Friedrich Kremer,et al.  Broadband dielectric spectroscopy , 2003 .

[14]  Kama Huang,et al.  The empirical formula for calculating the complex effective permittivity of an aqueous electrolyte solution at microwave frequency , 2005, IEEE Transactions on Geoscience and Remote Sensing.

[15]  S. Safavi-Naeini,et al.  Travelling-wave whispering gallery resonance sensor in millimetre-wave range , 2008 .

[16]  M A Stuchly,et al.  Dielectric properties of animal tissues in vivo at radio and microwave frequencies: comparison between species. , 1982, Physics in medicine and biology.

[17]  W. J. Ellisona Permittivity of Pure Water, at Standard Atmospheric Pressure, over the Frequency Range 0–25 THz and the Temperature Range 0–100 °C , 2007 .

[18]  H. Schwan Electrical properties of tissues and cell suspensions: mechanisms and models , 1994, Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[19]  Jong-Gwan Yook,et al.  DNA sensing using split-ring resonator alone at microwave regime , 2010 .

[20]  B. Kapilevich,et al.  Optimized Microwave Sensor for Online Concentration Measurements of Binary Liquid Mixtures , 2011, IEEE Sensors Journal.

[21]  Nihad Dib,et al.  A class of novel uniplanar series resonators and their implementation in original applications , 1998 .

[22]  R. Clarke,et al.  A review of RF and microwave techniques for dielectric measurements on polar liquids , 2006, IEEE Transactions on Dielectrics and Electrical Insulation.