Bortezomib partially protects the rat diaphragm from ventilator-induced diaphragm dysfunction*

Controlled mechanical ventilation leads to diaphragmatic contractile dysfunction and atrophy. Since proteolysis is enhanced in the diaphragm during controlled mechanical ventilation, we examined whether the administration of a proteasome inhibitor, Bortezomib, would have a protective effect against ventilator‐induced diaphragm dysfunction.

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