Low expression of asparagine synthetase in lymphoid blasts precludes its role in sensitivity to L-asparaginase.

[1]  A. Zelenetz,et al.  Acute lymphoblastic leukemia. , 2019, Journal of the National Comprehensive Cancer Network : JNCCN.

[2]  D. Neuberg,et al.  ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia. , 2011, Blood.

[3]  T. Anthony,et al.  The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase. , 2010, The Journal of nutrition.

[4]  H. Drexler,et al.  History of leukemia-lymphoma cell lines , 2010, Human Cell.

[5]  T. Anthony,et al.  GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase* , 2009, The Journal of Biological Chemistry.

[6]  Marc N. Offman,et al.  A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase. , 2009, The Journal of clinical investigation.

[7]  S. Hunger,et al.  Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines , 2008, Pediatric blood & cancer.

[8]  J. Downing,et al.  Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. , 2007, The Journal of clinical investigation.

[9]  M. Delorenzi,et al.  Gene expression profiling reveals consistent differences between clinical samples of human leukaemias and their model cell lines , 2006, British journal of haematology.

[10]  M. D. Den Boer,et al.  Up-regulation of asparagine synthetase expression is not linked to the clinical response L-asparaginase in pediatric acute lymphoblastic leukemia. , 2006, Blood.

[11]  A. Hall,et al.  Expression levels of asparagine synthetase in blasts from children and adults with acute lymphoblastic leukaemia , 2006, British journal of haematology.

[12]  W. Evans,et al.  Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia. , 2005, Blood.

[13]  L. Boxer,et al.  A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia. , 2005, Cancer research.

[14]  Cheng Cheng,et al.  Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. , 2004, The New England journal of medicine.

[15]  O. Hrusak,et al.  Upregulation of asparagine synthetase fails to avert cell cycle arrest induced by L-asparaginase in TEL/AML1-positive leukaemic cells , 2004, Leukemia.

[16]  M. D. Den Boer,et al.  Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia. , 2003, Blood.

[17]  M. D. Den Boer,et al.  Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL. , 2003, Blood.

[18]  M. Kilberg,et al.  Asparagine synthetase expression alone is sufficient to induce l-asparaginase resistance in MOLT-4 human leukaemia cells. , 2001, The Biochemical journal.

[19]  S. Schuster,et al.  Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements. , 2000, The Journal of biological chemistry.

[20]  R. Pieters,et al.  TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia. , 2000, Blood.

[21]  M. Amylon,et al.  Intensive high-dose asparaginase consolidation improves survival for pediatric patients with T cell acute lymphoblastic leukemia and advanced stage lymphoblastic lymphoma: a Pediatric Oncology Group study , 1999, Leukemia.

[22]  R. Pieters,et al.  In Vitro Cellular Drug Resistance and Prognosis in Newly Diagnosed Childhood Acute Lymphoblastic Leukemia , 1997 .

[23]  S. Schuster,et al.  Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells. , 1997, The American journal of physiology.

[24]  R. Pieters,et al.  In vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions , 1990 .

[25]  S. Sallan,et al.  In vitro and in vivo killing of acute lymphoblastic leukemia cells by L-asparaginase. , 1989, Cancer research.

[26]  R. Pieters,et al.  Comparison of the rapid automated MTT-assay with a dye exclusion assay for chemosensitivity testing in childhood leukaemia. , 1989, British Journal of Cancer.

[27]  R. Gelber,et al.  Influence of intensive asparaginase in the treatment of childhood non-T-cell acute lymphoblastic leukemia. , 1983, Cancer research.

[28]  B. Kim,et al.  L-asparaginase in the treatment of neoplastic diseases in children. , 1971, Cancer research.

[29]  J. Bertino,et al.  L-asparaginase: clinical, biochemical, pharmacological, and immunological studies. , 1971, Annals of internal medicine.

[30]  R. Handschumacher,et al.  Evaluation of L-asparagine metabolism in animals and man. , 1970, Cancer research.

[31]  D. Karnofsky,et al.  E. coli L‐asparaginase in the treatment of leukemia and solid tumors in 131 children , 1970, Cancer.

[32]  C. Haskell,et al.  l-asparaginase resistance in human leukemia--asparagine synthetase. , 1969, Biochemical pharmacology.

[33]  A. G. Bosanquet,et al.  Semi-micro adaptation of a 4-day differential staining cytotoxicity (DiSC) assay for determining the in-vitro chemosensitivity of haematological malignancies. , 1986, Leukemia research.

[34]  E. Gehan,et al.  L‐asparaginase therapy in children with advanced leukemia The Southwest cancer chemotherapy study group , 1971, Cancer.