Temazepam in fast dispensing dosage form as a premedication for children

Forty‐seven children aged between four and 11 years received temazepam 0.5 mg/kg in a novel fast dispensing dosage form. The preparation was well accepted and associated with few side‐effects. Satisfactory sedation and anxiolysis was obtained in over 93% of patients. The relative merits of a variety of routes of administration of premedicant drugs for children are discussed and the advantages of buccally administered formulations for this age group are presented.

[1]  J. Himberg,et al.  Midazolam versus atropine plus pethidine as premedication in children , 1984, Anaesthesia.

[2]  Tablets and capsules that stick in the oesophagus , 1981, The Journal of the Royal College of General Practitioners.

[3]  D. Breimer,et al.  Drug absorption by sublingual and rectal routes. , 1984, British journal of anaesthesia.

[4]  G. Gale,et al.  Sublingual lorazepam: a better premedication? , 1983, British journal of anaesthesia.

[5]  R. Burtles,et al.  Lorazepam in children. A double-blind trial comparing lorazepam, diazepam, trimeprazine and placebo. , 1983, British journal of anaesthesia.

[6]  J. Virjee,et al.  Effect of posture and drink volume on the swallowing of capsules. , 1982, British medical journal.

[7]  H. Hasselbalch,et al.  Oesophageal transit of six commonly used tablets and capsules. , 1982, British medical journal.

[8]  C. G. Peters,et al.  Comparative study of lorazepam and trimeprazine for oral premedication in paediatric anaesthesia. , 1982, British journal of anaesthesia.

[9]  E. Major,et al.  Temazepam as premedication in elderly patients , 1982, Anaesthesia.

[10]  J. Kanto Benzodiazepines as oral premedicants. , 1981, British Journal of Anaesthesia.

[11]  R. Eltringham,et al.  Temazepam as premedication in day surgery , 1981, Anaesthesia.

[12]  Kanthie Amarasekera Temazepam as a premedicant in minor surgery , 1980, Anaesthesia.

[13]  J. Stewart,et al.  Comparison of three benzodiazepines for oral premedication in minor gynaecological surgery. , 1980, British journal of anaesthesia.

[14]  J. Himberg,et al.  Comparison of oral triclofos, diazepam and flunitrazepam as premedicants in children undergoing otolaryngological surgery. , 1980, British journal of anaesthesia.

[15]  E. Valovirta,et al.  A comparative study on the clinical effects of rectal diazepam and pentobarbital on small children. Relationship between plasma level and effect. , 1980, International journal of clinical pharmacology, therapy, and toxicology.

[16]  L. Fuccella Bioavailability of temazepam in soft gelatin capsules. , 1979, British journal of clinical pharmacology.

[17]  F. Richardson,et al.  Comparison of flunitrazepam and diazepam for oral premedication in older children. , 1979, British journal of anaesthesia.

[18]  H. Schwarz Pharmacokinetics and metabolism of temazepam in man and several animal species. , 1979, British journal of clinical pharmacology.

[19]  J. Himberg,et al.  Comparison of I.M. pethidine, diazepam and flunitrazepam as premedicants in children undergoing otolaryngological surgery. , 1979, British journal of anaesthesia.

[20]  J. Dundee,et al.  THE BENZODIAZEPINES: A review of their actions and uses relative to anaesthetic practice , 1970 .

[21]  N. Gordon,et al.  Oral paediatric premedication. A comparative trial of either phenobarbitone, trimeprazine or diazepam with hyoscine, prior to guillotine tonsillectomy. , 1969, British journal of anaesthesia.

[22]  J. Dundee,et al.  Studies of drugs given before anaesthesia. XVI. Oral diazepam and trimeprazine for adenotonsillectomy. , 1968, British journal of anaesthesia.