Mechanisms of pain

Persistent or chronic pain is the primary reason people seek medical care, yet current therapies are either inadequate for certain types of pain or cause intolerable side effects. Recently, pain neurobiologists have identified a number of cellular and molecular processes that lead to the initiation and maintenance of pain. Understanding these underlying mechanisms has given significant promise for the development of more effective, more specific pain therapies in the near future.

[1]  D. Wilkin,et al.  Neuron , 2001, Brain Research.

[2]  T. Hökfelt,et al.  Down-regulation of μ-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy , 1997, Neuroscience.

[3]  E. Mccleskey,et al.  Ion channels of nociception. , 2020, Annual review of physiology.

[4]  C. Stucky,et al.  Isolectin B4-Positive and -Negative Nociceptors Are Functionally Distinct , 1999, The Journal of Neuroscience.

[5]  Brigitte L. Kieffer,et al.  Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene , 1996, Nature.

[6]  D. Price,et al.  Cholecystokinin and its antagonist lorglumide respectively attenuate and facilitate morphine-induced inhibition of C-fiber evoked discharges of dorsal horn nociceptive neurons , 1991, Brain Research.

[7]  S. McMahon,et al.  A Distinct Subgroup of Small DRG Cells Express GDNF Receptor Components and GDNF Is Protective for These Neurons after Nerve Injury , 1998, The Journal of Neuroscience.

[8]  W. Snider,et al.  IB4-Binding DRG Neurons Switch from NGF to GDNF Dependence in Early Postnatal Life , 1997, Neuron.

[9]  D. Julius,et al.  The capsaicin receptor: a heat-activated ion channel in the pain pathway , 1997, Nature.

[10]  J. Loeser,et al.  Bonica's Management of Pain , 2001 .

[11]  A I Basbaum,et al.  Impaired nociception and pain sensation in mice lacking the capsaicin receptor. , 2000, Science.

[12]  S. Bingham,et al.  Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia , 2000, Nature.

[13]  S. McMahon,et al.  Tackling Pain at the Source: New Ideas about Nociceptors , 1998, Neuron.

[14]  Stephen P. Hunt,et al.  The molecular dynamics of pain control , 2001, Nature Reviews Neuroscience.

[15]  C Peter N Watson.  The Treatment of Neuropathic Pain: Antidepressants and Opiodis , 2000, The Clinical journal of pain.

[16]  C. Woolf,et al.  Neuronal plasticity: increasing the gain in pain. , 2000, Science.

[17]  T. Hökfelt,et al.  Effect of morphine on cholecystokinin and μ-opioid receptor-like immunoreactivities in rat spinal dorsal horn neurons after peripheral axotomy and inflammation , 1999, Neuroscience.

[18]  S. McMahon,et al.  Immunocytochemical Localization of trkA Receptors in Chemically Identified Subgroups of Adult Rat Sensory Neurons , 1995, The European journal of neuroscience.

[19]  Paul E. Turner,et al.  Prisoner's dilemma in an RNA virus , 1999, Nature.