A drug-induced accelerated senescence (DIAS) is a possibility to study aging in time lapse
暂无分享,去创建一个
J. Diekmann | P. Brenneisen | Lirija Alili | M. Giesen | O. Holtkötter | O. Holtkötter | Johanna Diekmann
[1] Z. Darżynkiewicz,et al. Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence , 2012, Cell cycle.
[2] Angela T. Noon,et al. 53BP1-mediated DNA double strand break repair: insert bad pun here. , 2011, DNA repair.
[3] D. Laskin,et al. Distinct Roles of Cytochrome P450 Reductase in Mitomycin c Redox Cycling and Cytotoxicity , 2010, Molecular Cancer Therapeutics.
[4] J. Campisi,et al. The senescence-associated secretory phenotype: the dark side of tumor suppression. , 2010, Annual review of pathology.
[5] A. Bokov,et al. Is the oxidative stress theory of aging dead? , 2009, Biochimica et biophysica acta.
[6] D. Gems,et al. Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong? , 2009, Cell cycle.
[7] A. Viel,et al. Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers , 2009, Molecular Cancer Therapeutics.
[8] J. Campisi,et al. Cellular senescence: when bad things happen to good cells , 2007, Nature Reviews Molecular Cell Biology.
[9] Daohong Zhou,et al. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. , 2007, Free radical biology & medicine.
[10] Jun Ma. Gene Expression and Regulation , 2006 .
[11] G. Hunninghake,et al. Cigarette smoke induces cellular senescence. , 2006, American journal of respiratory cell and molecular biology.
[12] H. Magnussen,et al. Lung fibroblasts from patients with emphysema show markers of senescence in vitro , 2006, Respiratory research.
[13] T. Tong,et al. Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. , 2005, The international journal of biochemistry & cell biology.
[14] B. Herbert,et al. Telomere dysfunction in aging and cancer. , 2005, The international journal of biochemistry & cell biology.
[15] J. Campisi. Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors , 2005, Cell.
[16] J. Remacle,et al. Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase , 2004, Experimental Gerontology.
[17] John M Sedivy,et al. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). , 2004, Molecular cell.
[18] S. Jackson,et al. Activation of the DNA Damage Response by Telomere Attrition: A Passage to Cellular Senescence , 2004, Cell cycle.
[19] Stefanie Dimmeler,et al. Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative Senescence of Endothelial Cells , 2004, Circulation research.
[20] J. Petrini,et al. Activation of the DNA damage response by telomere attrition: a passage to cellular senescence. , 2004 .
[21] A. Multani,et al. N-Methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA , 2004, Molecular Cancer.
[22] D. Bernard,et al. Involvement of Rel/Nuclear Factor-κB Transcription Factors in Keratinocyte Senescence , 2004, Cancer Research.
[23] Daohong Zhou,et al. Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. , 2003, Cancer research.
[24] K. Scharffetter-Kochanek,et al. Ultraviolet‐B Irradiation and Matrix Metalloproteinases , 2002 .
[25] H. Schramek,et al. Replicative senescence of human fibroblasts: the role of Ras-dependent signaling and oxidative stress , 2002, Experimental Gerontology.
[26] C. Griffiths. The role of retinoids in the prevention and repair of aged and photoaged skin , 2001, Clinical and experimental dermatology.
[27] Qin M. Chen,et al. Subcytotoxic H2O2 Stress Triggers a Release of Transforming Growth Factor-β1, Which Induces Biomarkers of Cellular Senescence of Human Diploid Fibroblasts* , 2001, The Journal of Biological Chemistry.
[28] T. Halazonetis,et al. P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks , 2000, The Journal of cell biology.
[29] K. Scharffetter-Kochanek,et al. Isolation and identification of psoralen plus ultraviolet A (PUVA)-induced genes in human dermal fibroblasts by polymerase chain reaction-based subtractive hybridization. , 2000, The Journal of investigative dermatology.
[30] E. Medrano,et al. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes , 2000, Experimental Gerontology.
[31] B. Ames,et al. N-t-Butyl Hydroxylamine, a Hydrolysis Product of α-Phenyl-N-t-butyl Nitrone, Is More Potent in Delaying Senescence in Human Lung Fibroblasts* , 2000, The Journal of Biological Chemistry.
[32] M. Tomasz,et al. Mitomycin C linked to DNA minor groove binding agents: synthesis, reductive activation, DNA binding and cross-linking properties and in vitro antitumor activity. , 1999, Bioorganic & medicinal chemistry.
[33] P. Buehler,et al. Permanent cell cycle arrest in asynchronously proliferating normal human fibroblasts treated with doxorubicin or etoposide but not camptothecin. , 1999, Biochemical pharmacology.
[34] J. Sham,et al. Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells. , 1998, Cancer research.
[35] M. Tomasz,et al. The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity. , 1997, Pharmacology & therapeutics.
[36] C Roskelley,et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[37] M. Tomasz,et al. Mitomycin C: small, fast and deadly (but very selective). , 1995, Chemistry & biology.
[38] D. Lane,et al. Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.
[39] G. Stein,et al. Origins of G1 arrest in senescent human fibroblasts , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.
[40] P. Brenneisen,et al. DNA synthesis and Fos and Jun protein expression in mitotic and postmitotic WI-38 fibroblasts in vitro. , 1994, Experimental cell research.
[41] B. Ames,et al. Oxidants, antioxidants, and the degenerative diseases of aging. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[42] R. Pignolo,et al. Replicative senescence of human fibroblast-like cells in culture. , 1993, Physiological reviews.
[43] J. Remacle,et al. Aging as a multi-step process characterized by a lowering of entropy production leading the cell to a sequence of defined stages. II. Testing some predictions on aging human fibroblasts in culture , 1992, Mechanisms of Ageing and Development.
[44] J. Remacle,et al. Aging as a multi-step process characterized by a lowering of entropy production leading the cell to a sequence of defined stages , 1991, Mechanisms of Ageing and Development.
[45] H. Rodemann. Differential degradation of intracellular proteins in human skin fibroblasts of mitotic and mitomycin-C (MMC)-induced postmitotic differentiation states in vitro. , 1989, Differentiation; research in biological diversity.
[46] K. Dittmann,et al. Human skin fibroblasts in vitro differentiate along a terminal cell lineage. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[47] M. Tomasz,et al. Mechanism of monofunctional and bifunctional alkylation of DNA by mitomycin C. , 1988, Biochemistry.
[48] T. Mosmann. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.
[49] E. Schneider,et al. Increased nuclear sizes in senescent human diploid fibroblast cultures. , 1976, Experimental cell research.
[50] U. K. Laemmli,et al. Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.
[51] L. Hayflick,et al. The serial cultivation of human diploid cell strains. , 1961, Experimental cell research.
[52] G. Failla. THE AGING PROCESS AND CANCEROGENESIS , 1958, Annals of the New York Academy of Sciences.
[53] D. Harman. Aging: a theory based on free radical and radiation chemistry. , 1956, Journal of gerontology.
[54] Hannah J. Zhang,et al. An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. , 2007, American journal of physiology. Regulatory, integrative and comparative physiology.
[55] K. Scharffetter-Kochanek,et al. Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events. , 2002, Annals of the New York Academy of Sciences.
[56] Qin M. Chen,et al. Subcytotoxic H 2 O 2 Stress Triggers a Release of Transforming Growth Factor-b 1 , Which Induces Biomarkers of Cellular Senescence of Human Diploid Fibroblasts * , 2001 .
[57] C J Epstein,et al. Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.
[58] G. Yasuzumi,et al. Electron microscope observations of the metabolic nucleus. , 1953, Biochimica et biophysica acta.