Biologic drugs have revolutionized the treatments in many therapeutic areas and their pre and post-marketing evaluation is crucial for investigating their benefit-risk profile. The VALORE project is an AIFA (Italian Medicines Agency)-funded research project aiming at establishing a multi-regional network for the integrated analysis of healthcare and clinical data from different sources. Here we deal with the design and implementation of a data mart supporting the multidimensional data analysis. We also discuss the design of a portable architecture, making each regional center autonomous with respect to the required analysis. It is a first step in the direction of providing all the regional centers and AIFA with a common tool for the analysis and monitoring of marketed biologic drugs.