Wide-field surface plasmon microscopy of nano- and microparticles: features, benchmarking, limitations, and bioanalytical applications

Detection of nano- and micro-particles is an important task for chemical analytics, food industry, biotechnology, environmental monitoring and many other fields of science and industry. For this purpose, a method based on the detection and analysis of minute signals in surface plasmon resonance images due to adsorption of single nanopartciles was developed. This new technology allows one a real-time detection of interaction of single nano- and micro-particles with sensor surface. Adsorption of each nanoparticle leads to characteristic diffraction image whose intensity depends on the size and chemical composition of the particle. The adsorption rate characterizes volume concentration of nano- and micro-particles. Large monitored surface area of sensor enables a high dynamic range of counting and to a correspondingly high dynamic range in concentration scale. Depending on the type of particles and experimental conditions, the detection limit for aqueous samples can be below 1000 particles per microliter. For application of method in complex media, nanoparticle images are discriminated from image perturbations due to matrix components. First, the characteristic SPRM images of nanoparticles (templates) are collected in aqueous suspensions or spiked real samples. Then, the detection of nanoparticles in complex media using template matching is performed. The detection of various NPs in consumer products like cosmetics, mineral water, juices, and wines was shown at sub-ppb level. The method can be applied for ultrasensitive detection and analysis of nano- and micro-particles of biological (bacteria, viruses, endosomes), biotechnological (liposomes, protein nanoparticles for drug delivery) or technical origin.

[1]  V. Mirsky,et al.  Binding of protein nanoparticles to immobilized receptors , 2015 .

[2]  Reinhard Niessner,et al.  Computer assisted detection and quantification of single adsorbing nanoparticles by differential surface plasmon microscopy , 2015, Microchimica Acta.

[3]  S. Nizamov,et al.  The Role of Anion Adsorption in the Effect of Electrode Potential on Surface Plasmon Resonance Response. , 2017, Chemphyschem : a European journal of chemical physics and physical chemistry.

[4]  Yunze Yang,et al.  Label-free measuring and mapping of binding kinetics of membrane proteins in single living cells. , 2012, Nature chemistry.

[5]  Appling plasmonics based electrochemical microscopy to thin-layer electrochemistry , 2016 .

[6]  S. Nizamov,et al.  Individual Detection and Electrochemically Assisted Identification of Adsorbed Nanoparticles by Using Surface Plasmon Microscopy. , 2016, Angewandte Chemie.

[7]  Evgeny L. Gurevich,et al.  Analytical features of particle counting sensor based on plasmon assisted microscopy of nano objects , 2011 .

[8]  M. Engel,et al.  Signal Analysis and Classification for Surface Plasmon Assisted Microscopy of Nanoobjects , 2010 .

[9]  K. Überla,et al.  Real-time Detection of Single Immobilized Nanoparticles by Surface Plasmon Resonance Imaging , 2010 .

[10]  A. Kornyshev,et al.  Principles of nanoparticle imaging using surface plasmons , 2015 .

[11]  Wei Wang,et al.  Plasmonic Imaging of Electrochemical Reactions of Single Nanoparticles. , 2016, Accounts of chemical research.

[12]  Yuyuan Tian,et al.  Measuring the number concentration of arbitrarily-shaped gold nanoparticles with surface plasmon resonance microscopy , 2016, Science China Chemistry.

[13]  Peter Marwedel,et al.  Application of surface plasmon resonance imaging technique for the detection of single spherical biological submicrometer particles. , 2015, Analytical biochemistry.

[14]  Wei Wang,et al.  Plasmonic imaging of protein interactions with single bacterial cells. , 2015, Biosensors & bioelectronics.

[15]  Yuyuan Tian,et al.  Kinetics of small molecule interactions with membrane proteins in single cells measured with mechanical amplification , 2015, Science Advances.

[16]  K. Ino,et al.  Real-time monitoring biomarker expression of carcinoma cells by surface plasmon resonance biosensors. , 2012, Chemical communications.

[17]  A. Demetriadou.  The impact of natural modes in plasmonic imaging , 2015, Scientific Reports.

[18]  Yuyuan Tian,et al.  Imaging Local Heating and Thermal Diffusion of Nanomaterials with Plasmonic Thermal Microscopy. , 2015, ACS nano.

[19]  V. Scherbahn,et al.  Plasmonic detection and visualization of directed adsorption of charged single nanoparticles to patterned surfaces , 2016, Microchimica Acta.

[20]  R. Corn,et al.  Measuring Protein Binding to Individual Hydrogel Nanoparticles with Single-Nanoparticle Surface Plasmon Resonance Imaging Microscopy , 2016 .

[21]  R. Corn,et al.  Surface Plasmon Resonance Imaging Microscopy of Liposomes and Liposome-Encapsulated Gold Nanoparticles , 2016 .

[22]  Yong Wang,et al.  Single-nanoparticle near-infrared surface plasmon resonance microscopy for real-time measurements of DNA hybridization adsorption. , 2014, ACS nano.

[23]  Peter Wiktor,et al.  Imaging the electrocatalytic activity of single nanoparticles. , 2012, Nature nanotechnology.

[24]  Hongyuan Chen,et al.  Plasmonic imaging and detection of single DNA molecules. , 2014, ACS nano.

[25]  Yuyuan Tian,et al.  Determining the Absolute Concentration of Nanoparticles without Calibration Factor by Visualizing the Dynamic Processes of Interfacial Adsorption. , 2016, Analytical chemistry.

[26]  Andrew Wilkinson.  Compendium of Chemical Terminology , 1997 .

[27]  V. Scherbahn,et al.  Ionic Referencing in Surface Plasmon Microscopy: Visualization of the Difference in Surface Properties of Patterned Monomolecular Layers. , 2017, Analytical chemistry.

[28]  Peter Wiktor,et al.  Single cells and intracellular processes studied by a plasmonic-based electrochemical impedance microscopy. , 2011, Nature chemistry.

[29]  Yunze Yang,et al.  Antimicrobial Susceptibility Test with Plasmonic Imaging and Tracking of Single Bacterial Motions on Nanometer Scale. , 2016, ACS nano.

[30]  Heinrich Müller,et al.  Application of the PAMONO-Sensor for Quantification of Microvesicles and Determination of Nano-Particle Size Distribution , 2017, Sensors.

[31]  R. Corn,et al.  Measuring Melittin Uptake into Hydrogel Nanoparticles with Near-Infrared Single Nanoparticle Surface Plasmon Resonance Microscopy , 2015, Analytical chemistry.

[32]  Yuyuan Tian,et al.  Plasmonic imaging of electrochemical oxidation of single nanoparticles. , 2014, Journal of the American Chemical Society.

[33]  Yunze Yang,et al.  Label-Free Tracking of Single Organelle Transportation in Cells with Nanometer Precision Using a Plasmonic Imaging Technique. , 2015, Small.

[34]  V. Scherbahn,et al.  Detection and Quantification of Single Engineered Nanoparticles in Complex Samples Using Template Matching in Wide-Field Surface Plasmon Microscopy. , 2016, Analytical chemistry.

[35]  Patrick Soon-Shiong,et al.  Protein nanoparticles as drug carriers in clinical medicine. , 2008, Advanced drug delivery reviews.

[36]  Yuyuan Tian,et al.  Plasmonic Imaging of Surface Electrochemical Reactions of Single Gold Nanowires. , 2017, Journal of the American Chemical Society.

[37]  Xinping Huang,et al.  Label-free imaging, detection, and mass measurement of single viruses by surface plasmon resonance , 2010, Proceedings of the National Academy of Sciences.