Prevention and treatment of pressure ulcers.

Pressure ulcers are complex chronic wounds for which no gold standard for prevention or treatment has yet been established. Several attempts at developing guidelines has been undertaken by different organizations. Pressure ulcers are devastating comorbidities for patients and difficult to prevent or manage. Whether or not pressure ulcers are preventable remains controversial. The strategy for prevention includes recognizing the risk, decreasing the effects of pressure, assessing nutritional status, avoiding excessive bed rest and prolonged sitting, and preserving the integrity of the skin. The principles of treatment of pressure ulcers include assessing severity, reducing pressure, friction and shear forces, optimizing local wound care, removing necrotic debris, managing bacterial contamination, and correcting nutritional deficits.

[1]  T. Finucane Malnutrition, Tube Feeding and Pressure Sores: Data Are Incomplete , 1995, Journal of the American Geriatrics Society.

[2]  E. A. Nelson,et al.  Systematic reviews of wound care management: (2). Dressings and topical agents used in the healing of chronic wounds. , 1999, Health technology assessment.

[3]  D. Berlowitz,et al.  The Short‐Term Outcome of Pressure Sores , 1990, Journal of the American Geriatrics Society.

[4]  T. Defloor [Less frequent turning intervals and yet less pressure ulcers]. , 2001, Tijdschrift voor Gerontologie en Geriatrie.

[5]  H. Parpia,et al.  Human protein requirements. , 1971 .

[6]  I. Weinbren SPONTANEOUS PERIODIC ŒDEMA: A New Syndrome , 1963 .

[7]  M Hanlon,et al.  Reducing nosocomial pressure ulcers in an acute care facility. , 2000, Journal of nursing care quality.

[8]  D. Thomas,et al.  Prevention and treatment of pressure ulcers: what works? what doesn't? , 2001, Cleveland Clinic journal of medicine.

[9]  D Osterweil,et al.  A randomized trial of low-air-loss beds for treatment of pressure ulcers. , 1993, JAMA.

[10]  L. Bolton,et al.  A wound model for ischemic ulcers in the guinea pig , 1986, Archives of Dermatological Research.

[11]  WALTER 0. SEILER,et al.  Skin Oxygen Tension As a Function of Imposed Skin Pressure: Implication for Decubitus Ulcer Formation , 1979, Journal of the American Geriatrics Society.

[12]  M. Robson,et al.  Comparison of Silver Sulfadiazine, Povidone‐Iodine and Physiologic Saline in the Treatment of Chronic Pressure Ulcers , 1981, Journal of the American Geriatrics Society.

[13]  L. Phillips,et al.  Recombinant Human Platelet-derived Growth Factor-BB for the Treatment of Chronic Pressure Ulcers , 1992, Annals of plastic surgery.

[14]  M. Cesari,et al.  Topical Treatment of Pressure Ulcers with Nerve Growth Factor , 2003, Annals of Internal Medicine.

[15]  E. Siegler,et al.  Management of stage III pressure ulcers in moderately demented nursing home residents , 1991, Journal of General Internal Medicine.

[16]  J. Hermans,et al.  Pressure sores and tube feeding in patients with a fracture of the hip: a randomized clinical trial. , 1998, Clinical nutrition.

[17]  T. Helfman,et al.  Occlusive dressings and wound healing. , 1994, Clinics in dermatology.

[18]  J. Stechmiller,et al.  Arginine supplementation is well tolerated but does not enhance mitogen-induced lymphocyte proliferation in elderly nursing home residents with pressure ulcers. , 2000, JPEN. Journal of parenteral and enteral nutrition.

[19]  C. L. Johnson,et al.  Occlusive dressings: therapeutic agents and effects on drug delivery. , 1991, Clinics in dermatology.

[20]  G. Xakellis,et al.  Hydrocolloid versus saline-gauze dressings in treating pressure ulcers: a cost-effectiveness analysis. , 1992, Archives of physical medicine and rehabilitation.

[21]  P. Knipschild,et al.  Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers. , 1995, Journal of clinical epidemiology.

[22]  G. Rodeheaver,et al.  Chronic wounds: Palliative management for the frail population , 2002 .

[23]  G. Rodeheaver,et al.  Quality of care for hospitalized medicare patients at risk for pressure ulcers. , 2001, Archives of internal medicine.

[24]  You Chul Kim,et al.  Efficacy of hydrocolloid occlusive dressing technique in decubitus ulcer treatment: a comparative study. , 1996, Yonsei medical journal.

[25]  Jerry S. Vandeberg,et al.  Sequential cytokine therapy for pressure ulcers: clinical and mechanistic response. , 2000, Annals of surgery.

[26]  R. Allman,et al.  A phase II study to evaluate recombinant platelet-derived growth factor-BB in the treatment of stage 3 and 4 pressure ulcers. , 1994, Archives of surgery.

[27]  R. Frantz,et al.  Nursing Assessment: Impact on Type and Cost of Interventions to Prevent Pressure Ulcers , 1998, Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society.

[28]  M. McGuckin,et al.  Occlusive dressings: a microbiologic and clinical review. , 1990, American journal of infection control.

[29]  P. Lowthian Underpads in the Prevention of Decubiti , 1976 .

[30]  Steve Williams,et al.  Interim Analysis of a Prospective, Randomized Trial of Vacuum-Assisted Closure Versus the Healthpoint System in the Management of Pressure Ulcers , 2002, Annals of plastic surgery.

[31]  D. Thomas Pressure ulcer scale for healing, Derivation and varidation of the PUSH tool , 1997 .

[32]  D. Anthony,et al.  An investigation into the use of serum albumin in pressure sore prediction. , 2000, Journal of advanced nursing.

[33]  M. Sporn,et al.  Peptide growth factors and inflammation, tissue repair, and cancer. , 1986, The Journal of clinical investigation.

[34]  David R. Thomas Are all pressure ulcers avoidable? , 2001, Journal of the American Medical Directors Association.

[35]  P. Manson,et al.  Surgical correction of pressure ulcers in an urban center: is it efficacious? , 1994, Advances in wound care : the journal for prevention and healing.

[36]  S. D. Elek EXPERIMENTAL STAPHYLOCOCCAL INFECTIONS IN THE SKIN OF MAN , 1956, Annals of the New York Academy of Sciences.

[37]  T A Krouskop,et al.  Effectiveness of mattress overlays in reducing interface pressures during recumbency. , 1985, Journal of rehabilitation research and development.

[38]  M. Patrick,et al.  A National Study of Pressure Ulcer Prevalence and Incidence in Acute Care Hospitals , 2000, Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society.

[39]  L. Phillips,et al.  Platelet-derived growth factor BB for the treatment of chronic pressure ulcers , 1992, The Lancet.

[40]  R. Hendrix,et al.  The diagnosis of osteomyelitis in patients with pressure sores. , 1988, Plastic and reconstructive surgery.

[41]  M Meehan,et al.  National pressure ulcer prevalence survey. , 1994, Advances in wound care : the journal for prevention and healing.

[42]  P. Lamy,et al.  The Problem of Pressure Sores in a Nursing Home Population: Statistical Data , 1976, Journal of the American Geriatrics Society.

[43]  Anderson Ps,et al.  Effects of different turn intervals on skin of healthy older adults. , 1994 .

[44]  J. Milbrandt,et al.  Healing Pressure Ulcers with Collagen or Hydrocolloid: A Randomized, Controlled Trial , 2003, Journal of the American Geriatrics Society.

[45]  J. Ouslander,et al.  Air‐Fluidized Bed Treatment of Nursing Home Patients with Pressure Sores , 1989, Journal of the American Geriatrics Society.

[46]  W. Eaglstein,et al.  New methods for assessing epidermal wound healing: the effects of triamcinolone acetonide and polyethelene film occlusion. , 1978, The Journal of investigative dermatology.

[47]  D. Thomas,et al.  The role of nutrition in prevention and healing of pressure ulcers. , 1997, Clinics in geriatric medicine.

[48]  J. Witkowski,et al.  Cutaneous Ulcer Therapy , 1986, International journal of dermatology.

[49]  A. Chow,et al.  Sepsis associated with decubitus ulcers. , 1976, The American journal of medicine.

[50]  C. Lyder,et al.  Quality improvement in nursing homes in Texas: results from a pressure ulcer prevention project. , 2005, Journal of the American Medical Directors Association.

[51]  S Sprigle,et al.  Draft definition of stage I pressure ulcers: inclusion of persons with darkly pigmented skin. NPUAP Task Force on Stage I Definition and Darkly Pigmented Skin. , 1997, Advances in wound care : the journal for prevention and healing.

[52]  D. Smith,et al.  What is infection? , 1994, American journal of surgery.

[53]  J. Maklebust,et al.  Pressure relief characteristics of various support surfaces used in prevention and treatment of pressure ulcers , 1986, Journal of enterostomal therapy.

[54]  V. Falanga Occlusive wound dressings. Why, when, which? , 1988, Archives of dermatology.

[55]  J R Haalboom,et al.  A randomised, double-blind assessment of the effect of nutritional supplementation on the prevention of pressure ulcers in hip-fracture patients. , 2003, Clinical nutrition.

[56]  W. Eaglstein Experiences with biosynthetic dressings. , 1985, Journal of the American Academy of Dermatology.

[57]  T. Sheldon,et al.  The debridement of chronic wounds: a systematic review. , 1999, Health technology assessment.

[58]  M. Robson,et al.  Safety and effect of topical recombinant human interleukin‐1β in the management of pressure sores , 1994, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[59]  T. Taylor,et al.  Ascorbic acid supplementation in the treatment of pressure-sores. , 1974, Lancet.

[60]  K. M. Nelson,et al.  A physiologic basis for the provision of fuel mixtures in normal and stressed patients. , 1989 .

[61]  H. Munro,et al.  Human protein requirements: assessment of the adequacy of the current Recommended Dietary Allowance for dietary protein in elderly men and women. , 1982, The American journal of clinical nutrition.

[62]  D. Daltrey,et al.  Investigation into the microbial flora of healing and non-healing decubitus ulcers. , 1981, Journal of clinical pathology.

[63]  M. Bliss,et al.  Preventing pressure sores in geriatric patients. , 1967, Nursing mirror and midwives journal.

[64]  K. Inman,et al.  Clinical utility and cost-effectiveness of an air suspension bed in the prevention of pressure ulcers. , 1993, JAMA.

[65]  Are all pressure ulcers avoidable? , 2003, Journal of the American Medical Directors Association.

[66]  A. Goldberg,et al.  Malnutrition in tubefed nursing home patients with pressure sores. , 1991, JPEN - Journal of Parenteral and Enteral Nutrition.

[67]  J. Dartigues,et al.  A multi-center trial of the effects of oral nutritional supplementation in critically ill older inpatients. GAGE Group. Groupe Aquitain Geriatrique d'Evaluation. , 2000, Nutrition.

[68]  Nancy Bergstrom,et al.  A Prospective Study of Pressure Sore Risk among Institutionalized Elderly , 1992, Journal of the American Geriatrics Society.

[69]  J. Montgomerie,et al.  Quantitative microbiology of pressure sores in different stages of healing. , 1986, Diagnostic microbiology and infectious disease.

[70]  The limits of pressure sore prevention , 1999, Journal of the Royal Society of Medicine.

[71]  G. Pinchcofsky-Devin,et al.  Correlation of Pressure Sores and Nutritional Status , 1986, Journal of the American Geriatrics Society.

[72]  R. Allman,et al.  Pressure sores among hospitalized patients. , 1986, Annals of internal medicine.

[73]  J. Gallo,et al.  The efficacy of six heel pressure reducing devices. , 1991, Decubitus.

[74]  L. Gottlieb,et al.  Skin graft survival--the bacterial answer. , 1989 .

[75]  J N Morris,et al.  The epidemiology and natural history of pressure ulcers in elderly nursing home residents. , 1990, JAMA.

[76]  L. Broemeling,et al.  The Safety and Effect of Topically Applied Recombinant Basic Fibroblast Growth Factor on the Healing of Chronic Pressure Sores , 1992, Annals of surgery.

[77]  T. Koyama,et al.  Effects of Malnutrition on Development of Experimental Pressure Sores , 1992, The Journal of dermatology.

[78]  Moolten Se Bedsores in the chronically ill patient. , 1972 .

[79]  G. Mulder,et al.  Decubitus ulcers: update on new approaches to treatment. , 1988, Geriatrics.

[80]  D. Thomas Improving outcome of pressure ulcers with nutritional interventions: a review of the evidence. , 2001, Nutrition.

[81]  R. Diegelmann,et al.  Growth factors in wound healing. , 1994, Clinics in dermatology.

[82]  C. T. Henderson,et al.  Prolonged tube feeding in long-term care: nutritional status and clinical outcomes. , 1992, Journal of the American College of Nutrition.

[83]  R. Allman,et al.  Hospital‐Acquired Pressure Ulcers and Risk of Death , 1996, Journal of the American Geriatrics Society.

[84]  G. Pierer,et al.  VACUUM-ASSISTED WOUND CLOSURE FOR CHEAPER AND MORE COMFORTABLE HEALING OF PRESSURE SORES: A PROSPECTIVE STUDY , 2003, Scandinavian journal of plastic and reconstructive surgery and hand surgery.

[85]  C. Baxter Immunologic reactions in chronic wounds. , 1994, American journal of surgery.

[86]  J. Thornby,et al.  Evaluation of results and treatment variables for pressure ulcers in 48 veteran spinal cord-injured patients. , 1999, Annals of plastic surgery.

[87]  P. Delmas,et al.  Dietary supplementation in elderly patients with fractured neck of the femur , 1990, The Lancet.

[88]  C. Bryan,et al.  Bacteremia associated with decubitus ulcers. , 1983, Archives of internal medicine.

[89]  C. M. Martin,et al.  RELATIONSHIP OF QUANTITATIVE WOUND BACTERIAL COUNTS TO HEALING OF DECUBITI: EFFECT OF TOPICAL GENTAMICIN. , 1964, Antimicrobial agents and chemotherapy.

[90]  Dan Osterweil,et al.  The Minimum Data Set Pressure Ulcer Indicator: Does It Reflect Differences in Care Processes Related to Pressure Ulcer Prevention and Treatment in Nursing Homes? , 2003, Journal of the American Geriatrics Society.

[91]  E. J. Young,et al.  Osteomyelitis beneath pressure sores. , 1983, Archives of internal medicine.

[92]  R. Reynolds,et al.  THE EFFECT OF ORAL ZINC SULFATE THERAPY ON DECUBITUS ULCERS , 1971 .

[93]  R. Cook Ear syringing: This Continuing Education article reviews the knowledge and skills necessary to perform the clinical procedure of ear syringing , 1998 .

[94]  G. Rodeheaver,et al.  An instrument to measure healing in pressure ulcers: development and validation of the pressure ulcer scale for healing (PUSH). , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[95]  B. Crawley,et al.  The Importance of Dietary Protein in Healing Pressure Ulcers , 1993, Journal of the American Geriatrics Society.

[96]  M. Foreman,et al.  A comparison of the efficacy and cost-effectiveness of two methods of managing pressure ulcers. , 1993, Decubitus.

[97]  I. Bourdel-Marchasson,et al.  Prospective audits of quality of PEM recognition and nutritional support in critically ill elderly patients. , 1999, Clinical nutrition.

[98]  J. Guralnik,et al.  Occurrence and Predictors of Pressure Sores in the National Health and Nutrition Examination Survey Follow‐up , 1988, Journal of the American Geriatrics Society.

[99]  G. Gorse,et al.  Improved pressure sore healing with hydrocolloid dressings. , 1987, Archives of dermatology.

[100]  Pressure ulcers in the elderly: prevention and treatment utilizing the team approach. , 1981 .

[101]  M. Clark,et al.  Repositioning to prevent pressure sores--what is the evidence? , 1998, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

[102]  T A Sheldon,et al.  Beds, mattresses and cushions for pressure sore prevention and treatment. , 2000, The Cochrane database of systematic reviews.

[103]  H. Stähelin,et al.  Impaired migration of epidermal cells from decubitus ulcers in cell cultures. A cause of protracted wound healing? , 1989, American journal of clinical pathology.

[104]  J J Anderson,et al.  Are We Improving the Quality of Nursing Home Care: The Case of Pressure Ulcers , 2000, Journal of the American Geriatrics Society.

[105]  J. Disa,et al.  Efficacy of Operative Cure in Pressure Sore Patients , 1992, Plastic and reconstructive surgery.

[106]  J. Sokolow,et al.  Computed tomography of pressure sores, pelvic abscess, and osteomyelitis in patients with spinal cord injury. , 1982, Archives of physical medicine and rehabilitation.

[107]  C. Alessi,et al.  The Effects of an Exercise and Incontinence Intervention on Skin Health Outcomes in Nursing Home Residents , 2003, Journal of the American Geriatrics Society.

[108]  G. Kanel,et al.  Osteomyelitis associated with pressure ulcers. , 1986, Archives of physical medicine and rehabilitation.

[109]  D. M. Cooper,et al.  Definitions and guidelines for assessment of wounds and evaluation of healing. , 1994, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[110]  M. Robson,et al.  Becaplermin gel in the treatment of pressure ulcers: a phase II randomized, double‐blind, placebo‐controlled study , 1999, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[111]  Leyden Jj,et al.  Comparison of topical antibiotic ointments, a wound protectant, and antiseptics for the treatment of human blister wounds contaminated with Staphylococcus aureus. , 1987 .

[112]  D. Berlowitz,et al.  Risk Factors for Pressure Sores , 1989, Journal of the American Geriatrics Society.

[113]  R. Allman,et al.  Air-fluidized beds or conventional therapy for pressure sores. A randomized trial. , 1987, Annals of internal medicine.