Magnetizable implants and functionalized magnetic carriers: A novel approach for noninvasive yet targeted drug delivery

We describe a targeted drug delivery system consisting of two steps: first, intravenous injection and circulation of biocompatible, magnetic nanospheres encapsulated with a drug; and second, focal concentration and release of the drug at the target site utilizing an implanted, magnetizable intraluminal stent or seed. We introduce the system concept, outline the biomedical feasibility, and discuss potential clinical advantages.