ONE-POT SYNTHESIS OF NOVEL QUINAZOLINE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITY

One-pot synthetic methodology was adopted to synthesise final compounds. The synthesis of final compounds was done from starting compounds 2-(4-substituted)Phenyl benzoxazin-4-one and 2-Phenyl-benzoxazin-4-one. They were prepared from Anthranilic acid and 4-substituted and unsubstituted benzoyl chloride derivatives in presence of pyridine. A set of six Schiff bases were synthesized by reacting 2-(4-substituted)Phenyl-3amino Quinazoline -4-3(H)one and 2-Phenyl-3-amino Quinazoline -4-3(H)one with various substituted aromatic aldehydes in glass vials and placed in an oil bath at 80 degree celcius. Structural elucidation was done by spectroscopic method. The final compounds were screened for their antimicrobial activity