From sarcomeres to whole muscles.

The series connection of sarcomeres in a muscle raises the possibility of instabilities due to some sarcomeres being capable of greater isometric tension than others, due to non-uniform activation, cross-sectional area or sarcomere length. Such instabilities are heavily damped by the force-velocity curve and stabilized by passive tension. The variation of active tension with sarcomere length may act to stabilize or destabilize the situation. Such instabilities can affect tension in a complex manner, causing both increases and decreases in different situations. Some examples of situations where sarcomere nonuniformities have been observed or inferred are given, and their mode of action explained.

[1]  B. Katz.  The relation between force and speed in muscular contraction , 1939, The Journal of physiology.

[2]  B. C. Abbott,et al.  ABSTRACTS OF MEMOIRS RECORDING WORK DONE AT THE PLYMOUTH LABORATORY THE FORCE EXERTED BY ACTIVE STRIATED MUSCLE DURING AND AFTER CHANGE OF LENGTH , 2022 .

[3]  A. Huxley.  Muscle structure and theories of contraction. , 1957, Progress in biophysics and biophysical chemistry.

[4]  J. Délèze,et al.  The mechanical properties of the semitendinosus muscle at lengths greater than its length in the body , 1961, The Journal of physiology.

[5]  A. Huxley,et al.  The maximum length for contraction in vertebrate striated muscle , 1961, The Journal of physiology.

[6]  A. Huxley,et al.  Tension development in highly stretched vertebrate muscle fibres , 1966, The Journal of physiology.

[7]  K. Edman,et al.  The relation between sarcomere length and active tension in isolated semitendinosus fibres of the frog , 1966, The Journal of physiology.

[8]  A. Huxley,et al.  The variation in isometric tension with sarcomere length in vertebrate muscle fibres , 1966, The Journal of physiology.

[9]  R. Close.  Dynamic properties of mammalian skeletal muscles. , 1972, Physiological reviews.

[10]  J. Lännergren.  The force—velocity relation of isolated twitch and slow muscle fibres of Xenopus laevis , 1978, The Journal of physiology.

[11]  M. Noble,et al.  Enhancement of mechanical performance by stretch during tetanic contractions of vertebrate skeletal muscle fibres. , 1978, The Journal of physiology.

[12]  F. Julian,et al.  Sarcomere length non-uniformity in relation to tetanic responses of stretched skeletal muscle fibres , 1978, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[13]  K. Edman.  The velocity of unloaded shortening and its relation to sarcomere length and isometric force in vertebrate muscle fibres. , 1979, The Journal of physiology.

[14]  D L Morgan,et al.  Intersarcomere dynamics during fixed‐end tetanic contractions of frog muscle fibres. , 1979, The Journal of physiology.

[15]  D L Morgan,et al.  The effect on tension of non‐uniform distribution of length changes applied to frog muscle fibres. , 1979, The Journal of physiology.

[16]  Tension, stiffness, unloaded shortening speed and potentiation of frog muscle fibres at sarcomere lengths below optimum. , 1981, The Journal of physiology.

[17]  M. Noble,et al.  Residual force enhancement after stretch of contracting frog single muscle fibers , 1982, The Journal of general physiology.

[18]  S Mochon,et al.  A quantitative model of intersarcomere dynamics during fixed-end contractions of single frog muscle fibers. , 1982, Biophysical journal.

[19]  R. Baskin,et al.  Intersarcomere dynamics of single muscle fibers during fixed-end tetani , 1983, The Journal of general physiology.

[20]  G H Pollack,et al.  The cross-bridge theory. , 1983, Physiological reviews.

[21]  U Proske,et al.  Mechanical properties of toad slow muscle attributed to non‐uniform sarcomere lengths. , 1984, The Journal of physiology.

[22]  U. Proske,et al.  Non‐linear summation of tension in motor units of toad slow muscle. , 1984, The Journal of physiology.