EBHI-Seg: A novel enteroscope biopsy histopathological hematoxylin and eosin image dataset for image segmentation tasks

Background and purpose Colorectal cancer is a common fatal malignancy, the fourth most common cancer in men, and the third most common cancer in women worldwide. Timely detection of cancer in its early stages is essential for treating the disease. Currently, there is a lack of datasets for histopathological image segmentation of colorectal cancer, which often hampers the assessment accuracy when computer technology is used to aid in diagnosis. Methods This present study provided a new publicly available Enteroscope Biopsy Histopathological Hematoxylin and Eosin Image Dataset for Image Segmentation Tasks (EBHI-Seg). To demonstrate the validity and extensiveness of EBHI-Seg, the experimental results for EBHI-Seg are evaluated using classical machine learning methods and deep learning methods. Results The experimental results showed that deep learning methods had a better image segmentation performance when utilizing EBHI-Seg. The maximum accuracy of the Dice evaluation metric for the classical machine learning method is 0.948, while the Dice evaluation metric for the deep learning method is 0.965. Conclusion This publicly available dataset contained 4,456 images of six types of tumor differentiation stages and the corresponding ground truth images. The dataset can provide researchers with new segmentation algorithms for medical diagnosis of colorectal cancer, which can be used in the clinical setting to help doctors and patients. EBHI-Seg is publicly available at: https://figshare.com/articles/dataset/EBHI-SEG/21540159/1.

[1]  Frank Kulwa,et al.  Segmentation of Weakly Visible Environmental Microorganism Images Using Pair-wise Deep Learning Features , 2022, Biomed. Signal Process. Control..

[2]  N. Xu,et al.  CVM-Cervix: A Hybrid Cervical Pap-Smear Image Classification Framework Using CNN, Visual Transformer and Multilayer Perceptron , 2022, Pattern Recognit..

[3]  Xirong Li,et al.  A comparative study of gastric histopathology sub-size image classification: From linear regression to visual transformer , 2022, Frontiers in Medicine.

[4]  Shuojia Zou,et al.  TOD-CNN: An Effective Convolutional Neural Network for Tiny Object Detection in Sperm Videos , 2022, Comput. Biol. Medicine.

[5]  N. Rajpoot,et al.  AI based pre-screening of large bowel cancer via weakly supervised learning of colorectal biopsy histology images , 2022, medRxiv.

[6]  Chen Li,et al.  A Comprehensive Survey with Quantitative Comparison of Image Analysis Methods for Microorganism Biovolume Measurements , 2022, Archives of Computational Methods in Engineering.

[7]  Xirong Li,et al.  IL-MCAM: An interactive learning and multi-channel attention mechanism-based weakly supervised colorectal histopathology image classification approach , 2022, Comput. Biol. Medicine.

[8]  Chen Li,et al.  SVIA dataset: A new dataset of microscopic videos and images for computer-aided sperm analysis , 2022, Biocybernetics and Biomedical Engineering.

[9]  T. Kausar,et al.  SA-GAN: Stain Acclimation Generative Adversarial Network for Histopathology Image Analysis , 2021, Applied Sciences.

[10]  Amit Doegar,et al.  Breast cancer detection from histopathology images using modified residual neural networks , 2021, Biocybernetics and Biomedical Engineering.

[11]  Chen Li,et al.  Applications of artificial neural networks in microorganism image analysis: a comprehensive review from conventional multilayer perceptron to popular convolutional neural network and potential visual transformer , 2021, Artificial Intelligence Review.

[12]  Georgios S. Ioannidis,et al.  A neural pathomics framework for classifying colorectal cancer histopathology images based on wavelet multi-scale texture analysis , 2021, Scientific Reports.

[13]  Chen Li,et al.  A Comparative Study of Deep Learning Classification Methods on a Small Environmental Microorganism Image Dataset (EMDS-6): From Convolutional Neural Networks to Visual Transformers , 2021, Frontiers in Microbiology.

[14]  Sara P. Oliveira,et al.  CAD systems for colorectal cancer from WSI are still not ready for clinical acceptance , 2021, Scientific Reports.

[15]  Tao Jiang,et al.  LCU-Net: A novel low-cost U-Net for environmental microorganism image segmentation , 2021, Pattern Recognit..

[16]  Marcin Grzegorzek,et al.  A Comparison for Patch-level Classification of Deep Learning Methods on Transparent Environmental Microorganism Images: from Convolutional Neural Networks to Visual Transformers , 2021, 2106.11582.

[17]  Marcin Grzegorzek,et al.  GasHisSDB: A new gastric histopathology image dataset for computer aided diagnosis of gastric cancer , 2021, Comput. Biol. Medicine.

[18]  Marcin Grzegorzek,et al.  Is the aspect ratio of cells important in deep learning? A robust comparison of deep learning methods for multi-scale cytopathology cell image classification: From convolutional neural networks to visual transformers , 2021, Comput. Biol. Medicine.

[19]  Chen Li,et al.  A state-of-the-art survey of object detection techniques in microorganism image analysis: from classical methods to deep learning approaches , 2021, Artificial Intelligence Review.

[20]  Xirong Li,et al.  GasHis-Transformer: A multi-scale visual transformer approach for gastric histopathological image detection , 2021, Pattern Recognit..

[21]  Tao Jiang,et al.  A comprehensive review of image analysis methods for microorganism counting: from classical image processing to deep learning approaches , 2021, Artificial Intelligence Review.

[22]  Frank Kulwa,et al.  A new pairwise deep learning feature for environmental microorganism image analysis , 2021, Environmental Science and Pollution Research.

[23]  Chen Li,et al.  DeepCervix: A Deep Learning-based Framework for the Classification of Cervical Cells Using Hybrid Deep Feature Fusion Techniques , 2021, Comput. Biol. Medicine.

[24]  Chen Li,et al.  A hierarchical conditional random field-based attention mechanism approach for gastric histopathology image classification , 2021, Applied Intelligence.

[25]  Marcin Grzegorzek,et al.  A comprehensive review of computer-aided whole-slide image analysis: from datasets to feature extraction, segmentation, classification and detection approaches , 2021, Artificial Intelligence Review.

[26]  Vishal M. Patel,et al.  Medical Transformer: Gated Axial-Attention for Medical Image Segmentation , 2021, MICCAI.

[27]  A. Jemal,et al.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.

[28]  H. Exner,et al.  Scientific Reports , 2021, United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) Reports.

[29]  Jeny Rajan,et al.  Computational methods for automated mitosis detection in histopathology images: A review , 2020 .

[30]  Saeed Hassanpour,et al.  Learn like a Pathologist: Curriculum Learning by Annotator Agreement for Histopathology Image Classification , 2020, 2021 IEEE Winter Conference on Applications of Computer Vision (WACV).

[31]  Chen Li,et al.  A Comprehensive Review for MRF and CRF Approaches in Pathology Image Analysis , 2020, ArXiv.

[32]  Dervis Karaboga,et al.  A comprehensive review of deep learning in colon cancer , 2020, Comput. Biol. Medicine.

[33]  Xin Zhao,et al.  Identification of COVID-19 samples from chest X-Ray images using deep learning: A comparison of transfer learning approaches , 2020, Journal of X-ray science and technology.

[34]  Xiaorui Li,et al.  AN OTSU image segmentation based on fruitfly optimization algorithm , 2020 .

[35]  Erratum: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. , 2020, CA: a cancer journal for clinicians.

[36]  Chen Li,et al.  A Survey for Cervical Cytopathology Image Analysis Using Deep Learning , 2020, IEEE Access.

[37]  Chen Li,et al.  Gastric histopathology image segmentation using a hierarchical conditional random field , 2020, Biocybernetics and Biomedical Engineering.

[38]  V. Konda,et al.  Advances in endoscopy for colorectal polyp detection and classification , 2020, Proceedings.

[39]  Chen Li,et al.  A survey for the applications of content-based microscopic image analysis in microorganism classification domains , 2019, Artificial Intelligence Review.

[40]  Darshana Patel,et al.  Review of Medical Image Classification Techniques , 2018, Advances in Intelligent Systems and Computing.

[41]  2020 International Conference on Information Management and Technology (ICIMTech) , 2018, 2020 International Conference on Information Management and Technology (ICIMTech).

[42]  Eka Miranda,et al.  A survey of medical image classification techniques , 2016, 2016 International Conference on Information Management and Technology (ICIMTech).

[43]  Roberto Cipolla,et al.  SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation , 2015, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[44]  J. Chan,et al.  The Wonderful Colors of the Hematoxylin–Eosin Stain in Diagnostic Surgical Pathology , 2014, International journal of surgical pathology.

[45]  Baylor University Medical Center Proceedings , 2014 .

[46]  Yen-Lin Lee,et al.  Differences in Survival between Colon and Rectal Cancer from SEER Data , 2013, PloS one.

[47]  R. Labianca,et al.  Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. , 2013, Annals of oncology : official journal of the European Society for Medical Oncology.

[48]  Wei Ren,et al.  Missed diagnosis of early gastric cancer or high-grade intraepithelial neoplasia. , 2013, World journal of gastroenterology.

[49]  Hui Zhang,et al.  Probe into Image Segmentation Based on Sobel Operator and Maximum Entropy Algorithm , 2012, 2012 International Conference on Computer Science and Service System.

[50]  H. Irshad,et al.  Image segmentation using fuzzy clustering: A survey , 2010, 2010 6th International Conference on Emerging Technologies (ICET).

[51]  L. Burgart,et al.  Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps. , 2009, Archives of pathology & laboratory medicine.

[52]  A. Fischer,et al.  Hematoxylin and eosin staining of tissue and cell sections. , 2008, CSH protocols.

[53]  Rozemary Karamatic,et al.  High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. , 2006, Gastroenterology.

[54]  David A Clausi,et al.  Unsupervised image segmentation using a simple MRF model with a new implementation scheme , 2004, Proceedings of the 17th International Conference on Pattern Recognition, 2004. ICPR 2004..

[55]  Ron Kikinis,et al.  Statistical validation of image segmentation quality based on a spatial overlap index. , 2004, Academic radiology.

[56]  A. Karrenbeld,et al.  Diagnostic tests for Helicobacter pylori: a prospective evaluation of their accuracy, without selecting a single test as the gold standard. , 1996, The American journal of gastroenterology.

[57]  A. Karrenbeld,et al.  Diagnostic tests for H. pylori: A prospective evaluation of their accuracy with an independent “gold standard” , 1995 .

[58]  H. Baxter Williams,et al.  A Survey , 1992 .

[59]  O. Dodge Histological Typing of Intestinal Tumours , 1977 .

[60]  Chen Li,et al.  A New Gastric Histopathology Subsize Image Database (GasHisSDB) for Classification Algorithm Test: from Linear Regression to Visual Transformer , 2021, ArXiv.

[61]  X. S. Yang,et al.  Third International Congress on Information and Communication Technology , 2019, Advances in Intelligent Systems and Computing.

[62]  Olaf Ronneberger,et al.  Invited Talk: U-Net Convolutional Networks for Biomedical Image Segmentation , 2017, Bildverarbeitung für die Medizin.

[63]  Yambem Jina Chanu,et al.  Image Segmentation Using K -means Clustering Algorithm and Subtractive Clustering Algorithm , 2015 .

[64]  Musbah J. Aqel,et al.  Survey on Image Segmentation Techniques , 2015 .

[65]  Aihab Khan,et al.  Modified Watershed Algorithm for Segmentation of 2D Images , 2009 .

[66]  M. Ponz de Leòn,et al.  Pathology of colorectal cancer. , 2001, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[67]  J. Silverman,et al.  Pathology of the malignant colorectal polyp. , 1998, Human pathology.

[68]  Robert C. Wolpert,et al.  A Review of the , 1985 .

[69]  P. Jaccard,et al.  Etude comparative de la distribution florale dans une portion des Alpes et des Jura , 1901 .