Accelerating the controlled synthesis of metal-organic frameworks by a microfluidic approach: a nanoliter continuous reactor.

Segmented microfluidics was applied to the ultrafast crystallization of dicarboxylate based MIL-88B type metal-organic frameworks (MOFs; Fe-MIL-88B-NH2, Fe-MIL-88B, and Fe-MIL-88B-Br). Particular attention was paid to the influence of the temperature, residence time, and slug volume on the size and crystal size distribution of the MOFs. Average sizes in the 90-900 nm range with relatively narrow crystal size distributions were obtained with residence times as short as 20 s depending on the MOF type and synthesis conditions.

[1]  David Grosso,et al.  Green scalable aerosol synthesis of porous metal-organic frameworks. , 2013, Chemical communications.

[2]  R. Morris,et al.  Microwave-assisted synthesis of anionic metal-organic frameworks under ionothermal conditions. , 2006, Chemical communications.

[3]  S. Kuhn,et al.  Size-controlled flow synthesis of gold nanoparticles using a segmented flow microfluidic platform. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[4]  C. Riekel,et al.  How linker's modification controls swelling properties of highly flexible iron(III) dicarboxylates MIL-88. , 2011, Journal of the American Chemical Society.

[5]  C. Serre,et al.  Impact of the Flexible Character of MIL-88 Iron(III) Dicarboxylates on the Adsorption of n-Alkanes , 2013 .

[6]  B. Prasad,et al.  Segmented flow synthesis of Ag nanoparticles in spiral microreactor: Role of continuous and dispersed phase , 2012 .

[7]  Robert Puers,et al.  Digital Microfluidic High‐Throughput Printing of Single Metal‐Organic Framework Crystals , 2012, Advanced materials.

[8]  J. Ferraris,et al.  Mixed-matrix membranes containing MOF-5 for gas separations , 2009 .

[9]  C. Serre,et al.  High-throughput assisted rationalization of the formation of metal organic frameworks in the Iron(III) aminoterephthalate solvothermal system. , 2008, Inorganic chemistry.

[10]  C. Serre,et al.  Role of Solvent-Host Interactions That Lead to Very Large Swelling of Hybrid Frameworks , 2007, Science.

[11]  Gérard Férey,et al.  A route to the synthesis of trivalent transition-metal porous carboxylates with trimeric secondary building units. , 2004, Angewandte Chemie.

[12]  Yonggang Zhu,et al.  Positioning an individual metal–organic framework particle using a magnetic field , 2013 .

[13]  C. Serre,et al.  A new isoreticular class of metal-organic-frameworks with the MIL-88 topology. , 2006, Chemical communications.

[14]  Stefan Kaskel,et al.  Fine tuning of the metal–organic framework Cu3(BTC)2 HKUST-1 crystal size in the 100 nm to 5 micron range , 2012 .

[15]  Gérard Férey,et al.  BioMOFs: metal-organic frameworks for biological and medical applications. , 2010, Angewandte Chemie.

[16]  Dong-Pyo Kim,et al.  Ultrafast and continuous synthesis of unaccommodating inorganic nanomaterials in droplet- and ionic liquid-assisted microfluidic system. , 2011, Journal of the American Chemical Society.

[17]  C. Gaudin,et al.  A quantitative structure activity relationship approach to probe the influence of the functionalization on the drug encapsulation of porous metal-organic frameworks , 2012 .

[18]  A. Slawin,et al.  Synthesis, characterisation and adsorption properties of microporous scandium carboxylates with rigid and flexible frameworks , 2011 .

[19]  M. D. Rowe,et al.  Synthesis of gadolinium nanoscale metal-organic framework with hydrotropes: manipulation of particle size and magnetic resonance imaging capability. , 2011, ACS applied materials & interfaces.

[20]  F. Kapteijn,et al.  Manufacture of dense coatings of Cu3(BTC)2 (HKUST-1) on α-alumina , 2008 .

[21]  J. Lammertyn,et al.  Miniaturized Layer-by-Layer Deposition of Metal–Organic Framework Coatings through Digital Microfluidics , 2013 .

[22]  Mircea Dincă,et al.  Reductive electrosynthesis of crystalline metal-organic frameworks. , 2011, Journal of the American Chemical Society.

[23]  K. Jensen.  Microreaction engineering * is small better? , 2001 .

[24]  Nanping Xu,et al.  Preparation of Ultrafine Zeolite A Crystals with Narrow Particle Size Distribution Using a Two-Phase Liquid Segmented Microfluidic Reactor , 2009 .

[25]  J. M. Zamaro,et al.  Sonocrystallization of zeolitic imidazolate frameworks (ZIF-7, ZIF-8, ZIF-11 and ZIF-20) , 2012 .

[26]  B. Lotsch,et al.  Synthetic routes toward MOF nanomorphologies , 2012 .

[27]  J. M. Zamaro,et al.  Insight into the crystal synthesis, activation and application of ZIF-20 , 2011 .

[28]  T. Do,et al.  Novel route to size-controlled Fe-MIL-88B-NH2 metal-organic framework nanocrystals. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[29]  M. Roeffaers,et al.  Interfacial synthesis of hollow metal–organic framework capsules demonstrating selective permeability , 2011, Nature Chemistry.

[30]  Krista S. Walton,et al.  Kinetics study and crystallization process design for scale‐up of UiO‐66‐NH2 synthesis , 2013 .

[31]  Gérard Férey,et al.  Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. , 2010, Nature materials.

[32]  Omar K Farha,et al.  Fabrication of Metal‐Organic Framework‐Containing Silica‐Colloidal Crystals for Vapor Sensing , 2011, Advanced materials.

[33]  Daniel Gunzelmann,et al.  Synthesis and modification of a functionalized 3D open-framework structure with MIL-53 topology. , 2009, Inorganic chemistry.

[34]  C. Serre,et al.  Large breathing effects in three-dimensional porous hybrid matter: facts, analyses, rules and consequences. , 2009, Chemical Society reviews.

[35]  Karen J. Edler,et al.  Size-controlled synthesis of MIL-101(Cr) nanoparticles with enhanced selectivity for CO2 over N2 , 2011 .

[36]  Ruxandra Gref,et al.  Optimisation of the synthesis of MOF nanoparticles made of flexible porous iron fumarate MIL-88A , 2011 .

[37]  Inhar Imaz,et al.  A spray-drying strategy for synthesis of nanoscale metal-organic frameworks and their assembly into hollow superstructures. , 2013, Nature chemistry.

[38]  F. Emmerling,et al.  Mechanochemical Synthesis of Metal-Organic Frameworks : A Fast and FacileApproach towardQuantitativeYields andHighSpecific SurfaceAreas , 2010 .