Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers

Two types of photosensitizers are compared here for their singlet oxygen production and in vivo sensitizing capacity: Mg2+ and Zn2+-tetrabenzoporphyrin, which have a strong Q band at the HeNe laser line; and Cd-texaphyrin, with absorption at 770 nm. The singlet oxygen quantum yields in homogeneous solutions were determined by employing a singlet oxygen-destroyable fluorescent target. Photosensitizers of bacterial and human leukemic cells were carried out with these sensitizers, in comparison with HPD and Photofrin II. The new sensitizers were found to have high quantum yields for production of singlet oxygen in solutions. They also have comparable photosensitizing capacities of bacterial cells.

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