Suppression of mismatch negativity by backward masking predicts impaired working-memory performance in alcoholics.

BACKGROUND Pronounced disruption of memory traces by subsequent distractors may result in impaired behavioral memory performance in alcoholics. METHODS This hypothesis was investigated with an electrophysiological index of auditory sensory-memory traces, mismatch negativity, a preattentive event-related potential component elicited by a "deviant" tone within a train of "standard" tones. RESULTS Inserting a masking stimulus after these tones abolished mismatch negativity in alcoholics (DSM-IV) but not in social-drinker controls. This effect predicted working-memory impairment in alcoholics, and correlated significantly with self-reported alcohol consumption of the subjects. Furthermore, the backward-masking mismatch negativity paradigm detected sensory-memory impairment in 9 of 20 alcoholics (sensitivity 45%), whereas all 20 social drinkers were unimpaired (specificity 100%). CONCLUSIONS Vulnerability to memory trace disruption by shortly following sounds may be one of the factors contributing to behavioral memory dysfunction in alcoholics. The present result may provide an objective neurophysiological tool for investigation of alcohol-induced and other degenerative brain disorders.

[1]  Bernice Porjesz,et al.  Human Brain Electrophysiology and Alcoholism , 1985 .

[2]  J. Coyle,et al.  The glutamatergic basis of human alcoholism. , 1995, The American journal of psychiatry.

[3]  H. L. Williams,et al.  Alcoholism and family history of alcoholism: effects on visual and auditory event-related potentials. , 1987, Alcohol.

[4]  I. Winkler,et al.  Event-related brain potentials reflect traces of echoic memory in humans , 1993, Perception & psychophysics.

[5]  A Pfefferbaum,et al.  Event-related potential changes in chronic alcoholics. , 1979, Electroencephalography and clinical neurophysiology.

[6]  P. Sillanaukee,et al.  Effectiveness of the Alcohol Use Disorders Identification Test in occupational health screenings. , 1995, Alcoholism, clinical and experimental research.

[7]  M. Bear,et al.  Common forms of synaptic plasticity in the hippocampus and neocortex in vitro. , 1993, Science.

[8]  R. Näätänen,et al.  Early selective-attention effect on evoked potential reinterpreted. , 1978, Acta psychologica.

[9]  R. Ilmoniemi,et al.  Language-specific phoneme representations revealed by electric and magnetic brain responses , 1997, Nature.

[10]  D. Wechsler.  A Standardized Memory Scale for Clinical Use , 1945 .

[11]  I. Winkler,et al.  The effects of auditory backward masking on event-related brain potentials. , 1995, Electroencephalography and clinical neurophysiology. Supplement.

[12]  L. Cermak,et al.  Some comparisons of the memory and visuoperceptive deficits of chronic alcoholics and patients with Korsakoff's disease. , 1977, Alcoholism, clinical and experimental research.

[13]  N Butters,et al.  Cognitive loss and recovery in long-term alcohol abusers. , 1983, Archives of general psychiatry.

[14]  E. Gomberg.  Broadening the Base of Treatment for Alcohol Problems , 1992 .

[15]  R. Näätänen.  The Mismatch Negativity: A Powerful Tool for Cognitive Neuroscience , 1995, Ear and hearing.

[16]  N. Butters,et al.  Memory deficits in chronic alcoholics: continuities between the "intact" alcoholic and the alcoholic Korsakoff patient. , 1980, Advances in experimental medicine and biology.

[17]  D. Christman,et al.  Alteration of regional cerebral glucose metabolic rate in non-Korsakoff chronic alcoholism. , 1987, Archives of neurology.

[18]  D. Javitt,et al.  The Mismatch Negativity of Event‐Related Potentials as a Probe of Transient Auditory Memory: A Review , 1995, Ear and hearing.

[19]  S. Nixon,et al.  Neurocognitive Deficits and Recovery in Chronic Alcohol Abuse , 1999, CNS Spectrums.

[20]  K. Reinikainen,et al.  Attentive novelty detection in humans is governed by pre-attentive sensory memory , 1994, Nature.

[21]  S. Steinhauer,et al.  Event-related potentials in alcoholics and their first-degree relatives. , 1987, Alcohol.

[22]  A. Parkin,et al.  Aetiological Variation in the Amnesic Syndrome: Comparisons Using the Brown-Peterson Task , 1989, Cortex.

[23]  J. Ford,et al.  Event-related potentials in alcoholic men: P3 amplitude reflects family history but not alcohol consumption. , 1991, Alcoholism, clinical and experimental research.

[24]  J. Kril,et al.  Are we drinking our neurones away? , 1987, British medical journal.

[25]  R. Näätänen,et al.  Low dose of ethanol suppresses mismatch negativity of auditory event-related potentials. , 1995, Alcoholism, clinical and experimental research.

[26]  W. Lishman.  Alcohol and the Brain , 1990, British Journal of Psychiatry.

[27]  L. R. Peterson,et al.  Short-term retention of individual verbal items. , 1959, Journal of experimental psychology.

[28]  R. Harris,et al.  Neuroadaptive responses to chronic ethanol. , 1991, Alcoholism, clinical and experimental research.

[29]  N. Cowan.  Attention and Memory: An Integrated Framework , 1995 .

[30]  W. Lishman,et al.  Memory and ventricular size in alcoholics , 1987, Psychological Medicine.

[31]  L. Cermak,et al.  Reduced cerebral grey matter observed in alcoholics using magnetic resonance imaging. , 1991, Alcoholism, clinical and experimental research.

[32]  P W Woodruff,et al.  Reduced levels of GABA-benzodiazepine receptor in alcohol dependency in the absence of grey matter atrophy , 1998, British Journal of Psychiatry.

[33]  N. Volkow,et al.  Functional importance of ventricular enlargement and cortical atrophy in healthy subjects and alcoholics as assessed with PET, MR imaging, and neuropsychologic testing. , 1993, Radiology.

[34]  R. Näätänen,et al.  Selective acceleration of auditory processing in chronic alcoholics during abstinence. , 1998, Alcoholism, clinical and experimental research.

[35]  R A Koeppe,et al.  Cerebellar and frontal hypometabolism in alcoholic cerebellar degeneration studied with positron emission tomography , 1990, Annals of neurology.

[36]  T. Ishii.  A comparison of cerebral atrophy in CT scan findings among alcoholic groups , 1983, Acta psychiatrica Scandinavica. Supplementum.

[37]  N. Butters,et al.  Cognitive functioning in men social drinkers; a replication study. , 1982, Journal of studies on alcohol.

[38]  R. Näätänen.  Attention and brain function , 1992 .

[39]  P. Sillanaukee.  Laboratory markers of alcohol abuse. , 1996, Alcohol and alcoholism.

[40]  H. Yabe,et al.  Temporal window of integration revealed by MMN to sound omission , 1997, Neuroreport.

[41]  N. Cowan.  On short and long auditory stores. , 1984, Psychological bulletin.

[42]  M. Salamero,et al.  Regional cerebral blood flow-SPECT in chronic alcoholism: relation to neuropsychological testing. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[43]  P. Carlen,et al.  Cerebral atrophy and functional deficits in alcoholics without clinically apparent liver disease , 1981, Neurology.

[44]  C. Brewer,et al.  Brain damage due to alcohol consumption: an air-encephalographic, psychometric and electroencephalographic study. , 1971, The British journal of addiction to alcohol and other drugs.

[45]  J. Stroop.  Studies of interference in serial verbal reactions. , 1992 .

[46]  R. Knight,et al.  Clinical Neuropsychology of Alcoholism , 1994 .

[47]  M. George,et al.  Using Neuroimaging to Understand Alcohol's Brain Effects , 1999, CNS Spectrums.

[48]  L. Cermak,et al.  Alcoholic Korsakoff's Syndrome: An Information-Processing Approach to Amnesia , 1980 .

[49]  S. Borg,et al.  COMPUTED TOMOGRAPHY OF THE BRAIN AND NEUROPSYCHOLOGICAL ASSESSMENT OF MALE ALCOHOLIC PATIENTS AND A RANDOM SAMPLE FROM THE GENERAL MALE POPULATION , 1980, Acta psychiatrica Scandinavica. Supplementum.

[50]  J. Ahveninen,et al.  Post-withdrawal changes in middle-latency auditory evoked potentials in abstinent human alcoholics , 1999, Neuroscience Letters.

[51]  C. Grau,et al.  Multimodality exploration of event-related potentials in chronic alcoholics. , 1991, Alcoholism, clinical and experimental research.

[52]  H. Begleiter,et al.  Event-related potential evidence of dysfunction in automatic processing in abstinent alcoholics , 1993, Biological Psychiatry.

[53]  C. Naranjo,et al.  Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). , 1989, British journal of addiction.