Nicotinic receptors, allosteric proteins and medicine.

[1]  Jean-Pierre Changeux,et al.  Nicotinic acetylcholine receptors , 2008, Scholarpedia.

[2]  M. Burghammer,et al.  Crystal structure of the human β2 adrenergic G-protein-coupled receptor , 2007, Nature.

[3]  D. Bertrand,et al.  Allosteric modulation of nicotinic acetylcholine receptors. , 2007, Biochemical Pharmacology.

[4]  S. Arneric,et al.  Neuronal nicotinic receptors: a perspective on two decades of drug discovery research. , 2007, Biochemical pharmacology.

[5]  H. Lester,et al.  Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation. , 2007, Biochemical pharmacology.

[6]  M. Zoli,et al.  Heterogeneity and complexity of native brain nicotinic receptors. , 2007, Biochemical pharmacology.

[7]  C. Briggs,et al.  An Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo , 2007, Journal of Pharmacology and Experimental Therapeutics.

[8]  D. C. Chiara,et al.  [3H]Benzophenone photolabeling identifies state-dependent changes in nicotinic acetylcholine receptor structure. , 2007, Biochemistry.

[9]  J. Changeux,et al.  Docking of α-cobratoxin suggests a basal conformation of the nicotinic receptor , 2007 .

[10]  G. Lagoumintzis,et al.  Muscle and neuronal nicotinic acetylcholine receptors , 2007 .

[11]  T. Schwartz,et al.  Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act? , 2007, Trends in pharmacological sciences.

[12]  J. Stroud,et al.  Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 Å resolution , 2007, Nature Neuroscience.

[13]  S. Bartlett,et al.  Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking , 2007, Proceedings of the National Academy of Sciences.

[14]  B. Davidson,et al.  Transvascular delivery of small interfering RNA to the central nervous system , 2007, Nature.

[15]  A. Taly.  Opened by a twist: a gating mechanism for the nicotinic acetylcholine receptor , 2007, European Biophysics Journal.

[16]  P. Taylor,et al.  Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors. , 2007, Journal of molecular biology.

[17]  G. Heijne,et al.  The membrane protein universe: what's out there and why bother? , 2007 .

[18]  J. Changeux,et al.  Long-term effects of chronic nicotine exposure on brain nicotinic receptors , 2007, Proceedings of the National Academy of Sciences.

[19]  K. Gee,et al.  Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators , 2007, Proceedings of the National Academy of Sciences.

[20]  D. A. Kuzmin,et al.  Computer modeling of binding of diverse weak toxins to nicotinic acetylcholine receptors , 2007, Comput. Biol. Chem..

[21]  J. Changeux,et al.  A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family , 2007, Nature.

[22]  M. Karplus,et al.  Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors , 2006, Proceedings of the National Academy of Sciences.

[23]  Sébastien Dutertre,et al.  Toxin insights into nicotinic acetylcholine receptors. , 2006, Biochemical pharmacology.

[24]  H. Lester,et al.  The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo , 2006, Neuron.

[25]  Xiaolin Cheng,et al.  Targeted Molecular Dynamics Study of C-Loop Closure and Channel Gating in Nicotinic Receptors , 2006, PLoS Comput. Biol..

[26]  Weiliang Zhu,et al.  Molecular dynamics of nicotinic acetylcholine receptor correlating biological functions. , 2006, Current protein & peptide science.

[27]  A. Mourot,et al.  Dynamic Structural Investigations on the Torpedo Nicotinic Acetylcholine Receptor by Time‐Resolved Photoaffinity Labeling , 2006, Chembiochem : a European journal of chemical biology.

[28]  S. Sine,et al.  Recent advances in Cys-loop receptor structure and function , 2006, Nature.

[29]  D. Bertrand,et al.  Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[30]  J. Changeux,et al.  Nicotine enhances intracellular nicotinic receptor maturation: A novel mechanism of neural plasticity? , 2006, Journal of Physiology-Paris.

[31]  Probing the Reorganization of the Nicotinic Acetylcholine Receptor during Desensitization by Time-Resolved Covalent Labeling Using [3H]AC5, a Photoactivatable Agonist , 2006, Molecular Pharmacology.

[32]  C. Gotti,et al.  Brain neuronal nicotinic receptors as new targets for drug discovery. , 2006, Current pharmaceutical design.

[33]  Benzhuo Lu,et al.  Channel opening motion of alpha7 nicotinic acetylcholine receptor as suggested by normal mode analysis. , 2006, Journal of molecular biology.

[34]  E. Mitchell,et al.  Smoking and the Sudden Infant Death Syndrome , 2006, Reviews on Environmental Health.

[35]  J. Changeux,et al.  Molecular tuning of fast gating in pentameric ligand-gated ion channels. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[36]  R. Riek,et al.  3D structure of Alzheimer's amyloid-β(1–42) fibrils , 2005 .

[37]  Henry A. Lester,et al.  Cis–trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel , 2005, Nature.

[38]  J. Changeux,et al.  Pore conformations and gating mechanism of a Cys-loop receptor. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[39]  P. Taylor,et al.  Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations , 2005, The EMBO journal.

[40]  I. Bahar,et al.  Coarse-grained normal mode analysis in structural biology. , 2005, Current opinion in structural biology.

[41]  P. Greengard,et al.  Regulation of NMDA receptor trafficking by amyloid-β , 2005, Nature Neuroscience.

[42]  T. Liljefors,et al.  Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. , 2005, Journal of medicinal chemistry.

[43]  J. Changeux,et al.  Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors , 2005, Nature.

[44]  D. Bertrand,et al.  Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant , 2005, Nature Structural &Molecular Biology.

[45]  J. Changeux,et al.  Allosteric Mechanisms of Signal Transduction , 2005, Science.

[46]  S. Sine,et al.  Current understanding of congenital myasthenic syndromes. , 2005, Current opinion in pharmacology.

[47]  J. Changeux,et al.  Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism. , 2005, Biophysical journal.

[48]  D. Bertrand,et al.  A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization , 2005, The Journal of Neuroscience.

[49]  P. Taylor,et al.  Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α‐neurotoxins and nicotinic receptors , 2005, The EMBO journal.

[50]  N. Unwin,et al.  Refined structure of the nicotinic acetylcholine receptor at 4A resolution. , 2005, Journal of molecular biology.

[51]  J. Changeux,et al.  A chimera encoding the fusion of an acetylcholine-binding protein to an ion channel is stabilized in a state close to the desensitized form of ligand-gated ion channels. , 2005, Comptes rendus biologies.

[52]  P. Biggin,et al.  The α7 nicotinic acetylcholine receptor: Molecular modelling, electrostatics, and energetics , 2005 .

[53]  Steven M. Sine,et al.  Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel , 2004, Nature.

[54]  O. Steinlein.  Genetic mechanisms that underlie epilepsy , 2004, Nature Reviews Neuroscience.

[55]  T. Sixma,et al.  Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures , 2004, Neuron.

[56]  Philippe Faure,et al.  Executive and social behaviors under nicotinic receptor regulation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[57]  T. Sixma,et al.  Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels. , 2003, Annual review of biophysics and biomolecular structure.

[58]  J. Trudell,et al.  Coupling of agonist binding to channel gating in the GABAA receptor , 2003, Nature.

[59]  J. Changeux,et al.  β2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[60]  E. Levin,et al.  Nicotinic treatment for cognitive dysfunction. , 2002, Current drug targets. CNS and neurological disorders.

[61]  D. Bertrand,et al.  Structural Reorganization of the Acetylcholine Binding Site of the Torpedo Nicotinic Receptor as Revealed by Dynamic Photoaffinity Labeling , 2002, Chembiochem : a European journal of chemical biology.

[62]  J. Changeux,et al.  Experimentally based model of a complex between a snake toxin and the α7 nicotinic receptor , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[63]  J. Changeux,et al.  Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[64]  T. Sixma,et al.  Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors , 2001, Nature.

[65]  A Karlin,et al.  Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[66]  N. Unwin.  The Croonian Lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission. , 2000, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[67]  P. A. Peterson,et al.  β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity , 2000, The Journal of Biological Chemistry.

[68]  J. Changeux,et al.  Nicotinic receptors at the amino acid level. , 2000, Annual review of pharmacology and toxicology.

[69]  J P Changeux,et al.  Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor , 1998 .

[70]  J. Changeux,et al.  Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine , 1998, Nature.

[71]  J P Changeux,et al.  Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor. , 1996, The EMBO journal.

[72]  N. Unwin.  Acetylcholine receptor channel imaged in the open state , 1995, Nature.

[73]  Christophe Mulle,et al.  Potentiation of nicotinic receptor response by external calcium in rat central neurons , 1992, Neuron.

[74]  J. Galzi,et al.  Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[75]  M B Jackson,et al.  Kinetics of unliganded acetylcholine receptor channel gating. , 1986, Biophysical journal.

[76]  J P Changeux,et al.  On the nature of allosteric transitions: implications of non-exclusive ligand binding. , 1966, Journal of molecular biology.

[77]  D. Koshland,et al.  Comparison of experimental binding data and theoretical models in proteins containing subunits. , 1966, Biochemistry.

[78]  J. Changeux,et al.  ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. , 1965, Journal of molecular biology.

[79]  J. Changeux,et al.  Allosteric proteins and cellular control systems. , 1963, Journal of molecular biology.

[80]  J. Changeux,et al.  The feedback control mechanisms of biosynthetic L-threonine deaminase by L-isoleucine. , 1961, Cold Spring Harbor symposia on quantitative biology.

[81]  Bernard Katz,et al.  Interaction at end-plate receptors between different choline derivatives , 1957, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[82]  G. Adair.  THE HEMOGLOBIN SYSTEM VI. THE OXYGEN DISSOCIATION CURVE OF HEMOGLOBIN , 1925 .