All eggs in one basket: How potyvirus infection is controlled at a single cap-independent translation event.

[1]  B. L. Patil,et al.  RNA-Based Vaccination of Plants for Control of Viruses. , 2022, Annual review of virology.

[2]  Xinnian Dong,et al.  PABP/purine-rich motif as an initiation module for cap-independent translation in pattern-triggered immunity , 2022, Cell.

[3]  S. Saha,et al.  Interplay of HCPro and CP in the Regulation of Potato Virus A RNA Expression and Encapsidation , 2022, Viruses.

[4]  K. Ohshima,et al.  ICTV Virus Taxonomy Profile: Potyviridae 2022. , 2022, The Journal of general virology.

[5]  Aurélie M. Rakotondrafara,et al.  Multiple Cis-acting Polypyrimidine Tract Elements Regulate a Cooperative Mechanism for Triticum Mosaic Virus Internal Ribosomal Entry Site Activity , 2022, Frontiers in Plant Science.

[6]  J. Daròs,et al.  Proteome expansion in the Potyviridae evolutionary radiation , 2022, FEMS microbiology reviews.

[7]  Yalan Wang,et al.  Translation of Plant RNA Viruses , 2021, Viruses.

[8]  Ved Prakash,et al.  Metagenomics Analysis of the Wheat Virome Identifies Novel Plant and Fungal-Associated Viral Sequences , 2021, Viruses.

[9]  E. Koonin,et al.  Viruses Defined by the Position of the Virosphere within the Replicator Space , 2021, Microbiology and molecular biology reviews : MMBR.

[10]  Aiming Wang,et al.  Research Advances in Potyviruses: From the Laboratory Bench to the Field. , 2021, Annual review of phytopathology.

[11]  A. Siddiqui,et al.  N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition , 2021, Proceedings of the National Academy of Sciences.

[12]  Manabu Igarashi,et al.  Artificially Edited Alleles of the Eukaryotic Translation Initiation Factor 4E1 Gene Differentially Reduce Susceptibility to Cucumber Mosaic Virus and Potato Virus Y in Tomato , 2020, Frontiers in Microbiology.

[13]  A. Hinnebusch,et al.  eIF2α interactions with mRNA control accurate start codon selection by the translation preinitiation complex. , 2020, Nucleic acids research.

[14]  E. Koonin,et al.  Deep Roots and Splendid Boughs of the Global Plant Virome. , 2020, Annual review of phytopathology.

[15]  S. Saha,et al.  Insights into the Functions of eIF4E-Binding Motif of VPg in Potato Virus A Infection , 2020, Viruses.

[16]  Jiming Jiang,et al.  Overexpression of a modified eIF4E regulates potato virus Y resistance at the transcriptional level in potato , 2020, BMC Genomics.

[17]  A. V. von Arnim,et al.  Light-Dependent Activation of the GCN2 Kinase Under Cold and Salt Stress Is Mediated by the Photosynthetic Status of the Chloroplast , 2019, bioRxiv.

[18]  Xiangdong Li,et al.  A unique internal ribosome entry site representing a dynamic equilibrium state of RNA tertiary structure in the 5′-UTR of Wheat yellow mosaic virus RNA1 , 2019, Nucleic acids research.

[19]  M. Oeffinger,et al.  Structural studies of the eIF4E–VPg complex reveal a direct competition for capped RNA: Implications for translation , 2019, Proceedings of the National Academy of Sciences.

[20]  D. Bisaro,et al.  Phosphorylation of Arabidopsis eIF4E and eIFiso4E by SnRK1 inhibits translation , 2019, The FEBS journal.

[21]  H. Cui,et al.  The Biological Impact of the Hypervariable N-Terminal Region of Potyviral Genomes. , 2019, Annual review of virology.

[22]  C. Dardick,et al.  RNAi-Mediated Resistance Against Viruses in Perennial Fruit Plants , 2019, Plants.

[23]  S. Dinesh-Kumar,et al.  A new mechanism for translational control in plants , 2019, The FEBS journal.

[24]  H. Garcia-Ruiz.  Host factors against plant viruses , 2019, Molecular plant pathology.

[25]  R. Kormelink,et al.  Plant Viruses in Plant Molecular Pharming: Toward the Use of Enveloped Viruses , 2019, Front. Plant Sci..

[26]  C. Schmitt-Keichinger.  Manipulating Cellular Factors to Combat Viruses: A Case Study From the Plant Eukaryotic Translation Initiation Factors eIF4 , 2019, Front. Microbiol..

[27]  D. Goss,et al.  Poly (A) binding protein enhances the binding affinity of potyvirus VPg to eukaryotic initiation factor eIF4F and activates in vitro translation. , 2019, International journal of biological macromolecules.

[28]  M. Varjosalo,et al.  Ribosome profiles and riboproteomes of healthy and Potato virus A‐ and Agrobacterium‐infected Nicotiana benthamiana plants , 2018, Molecular plant pathology.

[29]  S. Thompson,et al.  Noncanonical Translation Initiation in Eukaryotes. , 2018, Cold Spring Harbor perspectives in biology.

[30]  Aurélie M. Rakotondrafara,et al.  The Triticum Mosaic Virus Internal Ribosome Entry Site Relies on a Picornavirus-Like YX-AUG Motif To Designate the Preferred Translation Initiation Site and To Likely Target the 18S rRNA , 2018, Journal of Virology.

[31]  M. Hamberg,et al.  Arabidopsis nonresponding to oxylipins locus NOXY7 encodes a yeast GCN1 homolog that mediates noncanonical translation regulation and stress adaptation. , 2018, Plant, cell & environment.

[32]  I. Nasir,et al.  A virus-derived short hairpin RNA confers resistance against sugarcane mosaic virus in transgenic sugarcane , 2018, Transgenic Research.

[33]  E. Martínez-Salas,et al.  Insights into Structural and Mechanistic Features of Viral IRES Elements , 2018, Front. Microbiol..

[34]  M. Aranda,et al.  Structural and Functional Diversity of Plant Virus 3′-Cap-Independent Translation Enhancers (3′-CITEs) , 2017, Front. Plant Sci..

[35]  Ji Wan,et al.  m6A Facilitates eIF4F-Independent mRNA Translation. , 2017, Molecular cell.

[36]  P. Simmonds,et al.  ICTV Virus Taxonomy Profile: Picornaviridae , 2017, The Journal of general virology.

[37]  S. Payne.  Introduction to RNA Viruses , 2017, Viruses.

[38]  C. Fraser,et al.  Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation , 2017, Proceedings of the National Academy of Sciences.

[39]  T. Michon,et al.  The Potyvirus Particle Recruits the Plant Translation Initiation Factor eIF4E by Means of the VPg covalently Linked to the Viral RNA. , 2017, Molecular plant-microbe interactions : MPMI.

[40]  Zhe Liang,et al.  N6-Methyladenosine RNA Modification Regulates Shoot Stem Cell Fate in Arabidopsis , 2017, Mechanisms of Development.

[41]  Lili Zhang,et al.  Eukaryotic translation initiation factor 2B‐beta (eIF2B&bgr;), a new class of plant virus resistance gene , 2017, The Plant journal : for cell and molecular biology.

[42]  C. Robaglia,et al.  eIF4E Resistance: Natural Variation Should Guide Gene Editing. , 2017, Trends in plant science.

[43]  Catharina Merchante,et al.  Translation regulation in plants: an interesting past, an exciting present and a promising future. , 2017, The Plant journal : for cell and molecular biology.

[44]  W. Miller,et al.  Non-canonical Translation in Plant RNA Viruses , 2017, Front. Plant Sci..

[45]  B. Semler,et al.  Mammalian Polycistronic mRNAs and Disease. , 2017, Trends in genetics : TIG.

[46]  K. Browning,et al.  The Triticum Mosaic Virus 5’ Leader Binds to Both eIF4G and eIFiso4G for Translation , 2017, PloS one.

[47]  Xiaofei Cheng,et al.  The Potyvirus Silencing Suppressor Protein VPg Mediates Degradation of SGS3 via Ubiquitination and Autophagy Pathways , 2016, Journal of Virology.

[48]  D. Walsh,et al.  A Cap-to-Tail Guide to mRNA Translation Strategies in Virus-Infected Cells. , 2016, Annual review of virology.

[49]  M. Gaglia,et al.  Shutoff of Host Gene Expression in Influenza A Virus and Herpesviruses: Similar Mechanisms and Common Themes , 2016, Viruses.

[50]  Z. Yakhini,et al.  Systematic discovery of cap-independent translation sequences in human and viral genomes , 2016, Science.

[51]  Hui-min Guo,et al.  Viral Genome-Linked Protein (VPg) Is Essential for Translation Initiation of Rabbit Hemorrhagic Disease Virus (RHDV) , 2015, PloS one.

[52]  Xueliang Hou,et al.  AtLa1 protein initiates IRES-dependent translation of WUSCHEL mRNA and regulates the stem cell homeostasis of Arabidopsis in response to environmental hazards. , 2015, Plant, cell & environment.

[53]  K. Browning,et al.  A Unique 5′ Translation Element Discovered in Triticum Mosaic Virus , 2015, Journal of Virology.

[54]  Aurélie M. Rakotondrafara,et al.  The role of the 5' untranslated regions of Potyviridae in translation. , 2015, Virus research.

[55]  A. Paul,et al.  Initiation of protein-primed picornavirus RNA synthesis. , 2015, Virus research.

[56]  Andrew E Firth,et al.  Transcriptional slippage in the positive-sense RNA virus family Potyviridae , 2015, EMBO reports.

[57]  H. Sanfaçon.  Plant Translation Factors and Virus Resistance , 2015, Viruses.

[58]  E. Martínez-Salas,et al.  Structural insights into viral IRES-dependent translation mechanisms. , 2015, Current opinion in virology.

[59]  D. Wemmer,et al.  Solution structure of the porcine sapovirus VPg core reveals a stable three-helical bundle with a conserved surface patch. , 2015, Biochemical and biophysical research communications.

[60]  W. Miller,et al.  Recruitment of the 40S Ribosome Subunit to the 3′-Untranslated Region (UTR) of a Viral mRNA, via the eIF4 Complex, Facilitates Cap-independent Translation* , 2015, The Journal of Biological Chemistry.

[61]  E. Pedroso,et al.  Local RNA flexibility perturbation of the IRES element induced by a novel ligand inhibits viral RNA translation , 2015, RNA biology.

[62]  Joanne Chory,et al.  NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism , 2015, Nature.

[63]  Y. Shirako,et al.  Association of VPg and eIF4E in the host tropism at the cellular level of Barley yellow mosaic virus and Wheat yellow mosaic virus in the genus Bymovirus. , 2015, Virology.

[64]  T. Michon,et al.  Cotranslational Coat Protein-Mediated Inhibition of Potyviral RNA Translation , 2015, Journal of Virology.

[65]  T. Hermann,et al.  Functional conservation despite structural divergence in ligand-responsive RNA switches , 2014, Proceedings of the National Academy of Sciences.

[66]  J. García,et al.  Resistance to Plum pox virus strain C in Arabidopsis thaliana and Chenopodium foetidum involves genome-linked viral protein and other viral determinants and might depend on compatibility with host translation initiation factors. , 2014, Molecular plant-microbe interactions : MPMI.

[67]  Nathalie Ulryck,et al.  40S recruitment in the absence of eIF4G/4A by EMCV IRES refines the model for translation initiation on the archetype of Type II IRESs , 2014, Nucleic acids research.

[68]  Y. Chaudhry,et al.  Sapovirus Translation Requires an Interaction between VPg and the Cap Binding Protein eIF4E , 2014, Journal of Virology.

[69]  P. Simpson,et al.  Structures of the Compact Helical Core Domains of Feline Calicivirus and Murine Norovirus VPg Proteins , 2013, Journal of Virology.

[70]  K. Mäkinen,et al.  Ribosomal Protein P0 Promotes Potato Virus A Infection and Functions in Viral Translation Together with VPg and eIF(iso)4E , 2013, Journal of Virology.

[71]  Aiming Wang,et al.  Silencing of the Host Factor eIF(iso)4E Gene Confers Plum Pox Virus Resistance in Plum , 2013, PloS one.

[72]  G. Rätsch,et al.  Polypyrimidine Tract Binding Protein Homologs from Arabidopsis Are Key Regulators of Alternative Splicing with Implications in Fundamental Developmental Processes[W] , 2012, Plant Cell.

[73]  F. Sobrino,et al.  Exploring IRES Region Accessibility by Interference of Foot-and-Mouth Disease Virus Infectivity , 2012, PloS one.

[74]  I. Brierley,et al.  Non-canonical translation in RNA viruses , 2012, The Journal of general virology.

[75]  C. Rommens,et al.  Overexpression of the wild potato eIF4E-1 variant Eva1 elicits Potato virus Y resistance in plants silenced for native eIF4E-1 , 2012, Transgenic Research.

[76]  J. Van Eck,et al.  Engineering virus resistance using a modified potato gene. , 2011, Plant biotechnology journal.

[77]  Peter F. Stadler,et al.  ViennaRNA Package 2.0 , 2011, Algorithms for Molecular Biology.

[78]  R. Jackson,et al.  The mechanism of translation initiation on Aichivirus RNA mediated by a novel type of picornavirus IRES , 2011, The EMBO journal.

[79]  K. Rantalainen,et al.  Potyviral VPg Enhances Viral RNA Translation and Inhibits Reporter mRNA Translation In Planta , 2011, Journal of Virology.

[80]  E. Wahle,et al.  Control of poly(A) tail length , 2011, Wiley interdisciplinary reviews. RNA.

[81]  R. Corbau,et al.  Selection, Optimization, and Pharmacokinetic Properties of a Novel, Potent Antiviral Locked Nucleic Acid-Based Antisense Oligomer Targeting Hepatitis C Virus Internal Ribosome Entry Site , 2011, Antimicrobial Agents and Chemotherapy.

[82]  I. Nasir,et al.  Potato virus Y mRNA expression knockdown mediated by siRNAs in cultured mammalian cell line , 2011, Virologica Sinica.

[83]  J. Dinman,et al.  Ribosome Binding to a 5′ Translational Enhancer Is Altered in the Presence of the 3′ Untranslated Region in Cap-Independent Translation of Turnip Crinkle Virus , 2011, Journal of Virology.

[84]  A. Komar,et al.  Inhibition of Encephalomyocarditis Virus and Poliovirus Replication by Quinacrine: Implications for the Design and Discovery of Novel Antiviral Drugs , 2010, Journal of Virology.

[85]  R. Jackson,et al.  The mechanism of eukaryotic translation initiation and principles of its regulation , 2010, Nature Reviews Molecular Cell Biology.

[86]  E. Wimmer,et al.  The Making of a Picornavirus Genome , 2010 .

[87]  S. Whitham,et al.  Differential requirement of ribosomal protein S6 by plant RNA viruses with different translation initiation strategies. , 2009, Virology.

[88]  Amy D. Ziems,et al.  Triticum mosaic virus: a distinct member of the family potyviridae with an unusually long leader sequence. , 2009, Phytopathology.

[89]  Richard J Jackson,et al.  Polypyrimidine tract binding protein stabilizes the encephalomyocarditis virus IRES structure via binding multiple sites in a unique orientation. , 2009, Molecular cell.

[90]  Yingpu Yu,et al.  Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites , 2009, Proceedings of the National Academy of Sciences.

[91]  J. Kieft,et al.  Toward a structural understanding of IRES RNA function. , 2009, Current opinion in structural biology.

[92]  D. A. Stein,et al.  A Morpholino Oligomer Targeting Highly Conserved Internal Ribosome Entry Site Sequence Is Able To Inhibit Multiple Species of Picornavirus , 2008, Antimicrobial Agents and Chemotherapy.

[93]  Andrew E Firth,et al.  An overlapping essential gene in the Potyviridae , 2008, Proceedings of the National Academy of Sciences.

[94]  D. Goss,et al.  Potyvirus Genome-linked Protein, VPg, Directly Affects Wheat Germ in Vitro Translation , 2008, Journal of Biological Chemistry.

[95]  D. A. Stein,et al.  Inhibition of Foot-and-Mouth Disease Virus Infections in Cell Cultures with Antisense Morpholino Oligomers , 2007, Journal of Virology.

[96]  Dan Nettleton,et al.  Spatial analysis of arabidopsis thaliana gene expression in response to Turnip mosaic virus infection. , 2007, Molecular plant-microbe interactions : MPMI.

[97]  K. Lehto,et al.  The RNA2 5' leader of Blackcurrant reversion virus mediates efficient in vivo translation through an internal ribosomal entry site mechanism. , 2007, The Journal of general virology.

[98]  M. Turcotte,et al.  Searching for IRES. , 2006, RNA.

[99]  R. Johnston,et al.  Ribosomal Protein S6 Associates with Alphavirus Nonstructural Protein 2 and Mediates Expression from Alphavirus Messages , 2006, Journal of Virology.

[100]  H. Yumak,et al.  Tobacco Etch Virus mRNA Preferentially Binds Wheat Germ Eukaryotic Initiation Factor (eIF) 4G Rather than eIFiso4G* , 2006, Journal of Biological Chemistry.

[101]  D. Goss,et al.  Interaction of Genome-linked Protein (VPg) of Turnip Mosaic Virus with Wheat Germ Translation Initiation Factors eIFiso4E and eIFiso4F* , 2006, Journal of Biological Chemistry.

[102]  W. Miller,et al.  Translational control in positive strand RNA plant viruses. , 2006, Virology.

[103]  Brian Raught,et al.  Eukaryotic Translation Initiation Factor 4EAvailability Controls the Switch between Cap-Dependent andInternal Ribosomal Entry Site-MediatedTranslation , 2005, Molecular and Cellular Biology.

[104]  J. Laliberté,et al.  Calicivirus translation initiation requires an interaction between VPg and eIF4E , 2005, EMBO reports.

[105]  Vladimir V Zeenko,et al.  Cap-independent Translation of Tobacco Etch Virus Is Conferred by an RNA Pseudoknot in the 5′-Leader* , 2005, Journal of Biological Chemistry.

[106]  N. Perrimon,et al.  Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. , 2005, Genes & development.

[107]  N. Sonenberg,et al.  Regulation of cap-dependent translation by eIF4E inhibitory proteins , 2005, Nature.

[108]  C. Levis,et al.  The 5′ untranslated region of PVY RNA, even located in an internal position, enables initiation of translation , 1993, Virus Genes.

[109]  Y. Kaku,et al.  Functional and Structural Similarities between the Internal Ribosome Entry Sites of Hepatitis C Virus and Porcine Teschovirus, a Picornavirus , 2004, Journal of Virology.

[110]  J. Laliberté,et al.  Interaction of VPg-Pro of turnip mosaic virus with the translation initiation factor 4E and the poly(A)-binding protein in planta. , 2004, The Journal of general virology.

[111]  Vincent L. Chiang,et al.  Context sequences of translation initiation codon in plants , 1997, Plant Molecular Biology.

[112]  C. Hellen,et al.  Eukaryotic Initiation Factors 4G and 4A Mediate Conformational Changes Downstream of the Initiation Codon of the Encephalomyocarditis Virus Internal Ribosomal Entry Site , 2003, Molecular and Cellular Biology.

[113]  K. Kasschau,et al.  Loss-of-Susceptibility Mutants of Arabidopsis thaliana Reveal an Essential Role for eIF(iso)4E during Potyvirus Infection , 2002, Current Biology.

[114]  Jean-Jacques Toulmé,et al.  Apical loop-internal loop interactions: a new RNA-RNA recognition motif identified through in vitro selection against RNA hairpins of the hepatitis C virus mRNA. , 2002, Biochemistry.

[115]  J. Valkonen,et al.  Viral genome-linked protein (VPg) controls accumulation and phloem-loading of a potyvirus in inoculated potato leaves. , 2002, Molecular plant-microbe interactions : MPMI.

[116]  K. Browning,et al.  eIF4G Functionally Differs from eIFiso4G in Promoting Internal Initiation, Cap-independent Translation, and Translation of Structured mRNAs* , 2001, The Journal of Biological Chemistry.

[117]  A. Shatkin,et al.  Viral and cellular mRNA capping: Past and prospects , 2000, Advances in Virus Research.

[118]  Lukaszewicz,et al.  In vivo evaluation of the context sequence of the translation initiation codon in plants. , 2000, Plant science : an international journal of experimental plant biology.

[119]  M. Niepel,et al.  Identification and Characterization of the Functional Elements within the Tobacco Etch Virus 5′ Leader Required for Cap-Independent Translation , 1999, Journal of Virology.

[120]  C. Hellen,et al.  Translation Eukaryotic Initiation Factor 4G Recognizes a Specific Structural Element within the Internal Ribosome Entry Site of Encephalomyocarditis Virus RNA* , 1998, The Journal of Biological Chemistry.

[121]  R. Jackson,et al.  A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs. , 1998, Genes & development.

[122]  H. Masaki,et al.  Mutational analysis of the potato virus Y 5' untranslated region for alteration in translational enhancement in tobacco protoplasts. , 1997, Bioscience, biotechnology, and biochemistry.

[123]  J. García,et al.  Cap-independent leaky scanning as the mechanism of translation initiation of a plant viral genomic RNA. , 1997, The Journal of general virology.

[124]  Robert L. Tanguay,et al.  The tobacco etch viral 5' leader and poly(A) tail are functionally synergistic regulators of translation. , 1995, Gene.

[125]  P. Dallaire,et al.  Evidence for an internal ribosome entry site within the 5' non-translated region of turnip mosaic potyvirus RNA. , 1994, The Journal of general virology.

[126]  J. Riechmann,et al.  Identification of the initiation codon of plum pox potyvirus genomic RNA. , 1991, Virology.

[127]  W. Merrick,et al.  Eukaryotic initiation factor (eIF)-4F. Implications for a role in internal initiation of translation. , 1991, The Journal of biological chemistry.

[128]  J. Carrington,et al.  Cap-independent enhancement of translation by a plant potyvirus 5' nontranslated region , 1990, Journal of virology.

[129]  M. Kozak.  The scanning model for translation: an update , 1989, The Journal of cell biology.

[130]  H F Kern,et al.  Selection of AUG initiation codons differs in plants and animals. , 1987, The EMBO journal.

[131]  E. Wimmer,et al.  The 5'-terminal structures of poliovirion RNA and poliovirus mRNA differ only in the genome-linked protein VPg. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[132]  A. Shatkin.  Capping of eucaryotic mRNAs , 1976, Cell.