Modified High-Density Lipoproteins by Artificial Sweetener, Aspartame, and Saccharin, Showed Loss of Anti-atherosclerotic Activity and Toxicity in Zebrafish

[1]  A. Jenkins,et al.  Apolipoprotein A-I glycation by Glucose and Reactive Aldehydes Alters Phospholipid Affinity but Not Cholesterol Export from Lipid-Laden Macrophages , 2013, PloS one.

[2]  Y. Kokubo,et al.  Soft drink intake in relation to incident ischemic heart disease, stroke, and stroke subtypes in Japanese men and women: the Japan Public Health Centre-based study cohort I. , 2012, The American journal of clinical nutrition.

[3]  R. Blust,et al.  Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds. , 2012, Reproductive toxicology.

[4]  Kyung-Hyun Cho,et al.  A zebrafish model for the rapid evaluation of pro-oxidative and inflammatory death by lipopolysaccharide, oxidized low-density lipoproteins, and glycated high-density lipoproteins. , 2011, Fish & shellfish immunology.

[5]  Jae-Yong Kim,et al.  Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia. , 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[6]  Ki-Hoon Park,et al.  High-density lipoprotein (HDL) from elderly and reconstituted HDL containing glycated apolipoproteins A-I share proatherosclerotic and prosenescent properties with increased cholesterol influx. , 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

[7]  N. Jeoung,et al.  Modified apolipoprotein (apo) A-I by artificial sweetener causes severe premature cellular senescence and atherosclerosis with impairment of functional and structural properties of apoA-I in lipid-free and lipid-bound state , 2011, Molecules and cells.

[8]  Kyung-Hyun Cho,et al.  Severely modified lipoprotein properties without a change in cholesteryl ester transfer protein activity in patients with acute renal failure secondary to Hantaan virus infection. , 2010, BMB reports.

[9]  Dong-gu Shin,et al.  Senescence-related truncation and multimerization of apolipoprotein A-I in high-density lipoprotein with an elevated level of advanced glycated end products and cholesteryl ester transfer activity. , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[10]  Frank B. Hu,et al.  Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence , 2010, Physiology & Behavior.

[11]  Ki-yong Kim,et al.  Fructated apolipoprotein A-I showed severe structural modification and loss of beneficial functions in lipid-free and lipid-bound state with acceleration of atherosclerosis and senescence. , 2010, Biochemical and biophysical research communications.

[12]  Wim De Coen,et al.  Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo. , 2009, Reproductive toxicology.

[13]  C. Burkhart.  'Lone' atrial fibrillation precipitated by monosodium glutamate and aspartame. , 2009, International journal of cardiology.

[14]  Kyung-Hyun Cho,et al.  Biomedicinal implications of high-density lipoprotein: its composition, structure, functions, and clinical applications. , 2009, BMB reports.

[15]  Kyung-Hyun Cho,et al.  Synthesis of reconstituted high density lipoprotein (rHDL) containing apoA-I and apoC-III: the functional role of apoC-III in rHDL , 2009, Molecules and cells.

[16]  Dong-gu Shin,et al.  Myocardial infarction patients show altered lipoprotein properties and functions when compared with stable angina pectoris patients , 2009, Experimental & Molecular Medicine.

[17]  P. Barter,et al.  Antiinflammatory actions of HDL: a new insight. , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[18]  Utpal Banerjee,et al.  Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint , 2008, Nature Genetics.

[19]  Nikki Gillum,et al.  Cardiovasc Toxicol , 2008 .

[20]  A. Mukherjee,et al.  Genotoxicity Testing of Low-Calorie Sweeteners: Aspartame, Acesulfame-K, and Saccharin , 2008, Drug and chemical toxicology.

[21]  Takahiko Nakagawa,et al.  Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. , 2007, The American journal of clinical nutrition.

[22]  P. Hartge,et al.  Consumption of Aspartame-Containing Beverages and Incidence of Hematopoietic and Brain Malignancies , 2006, Cancer Epidemiology Biomarkers & Prevention.

[23]  L. Lambertini,et al.  Aspartame induces lymphomas and leukaemias in rats a L'aspartame induce linfomi e leucemie nei ratti , 2005 .

[24]  Ralf Dahm,et al.  Zebrafish: A Practical Approach. Edited by C. NÜSSLEIN-VOLHARD and R. DAHM. Oxford University Press. 2002. 322 pages. ISBN 0 19 963808 X. Price £40.00 (paperback). ISBN 0 19 963809 8. Price £80.00 (hardback). , 2003 .

[25]  A. Drewnowski,et al.  Journals of Gerontology , 2001 .

[26]  S. Preston‐Martin,et al.  Aspartame consumption in relation to childhood brain tumor risk: results from a case-control study. , 1997, Journal of the National Cancer Institute.

[27]  E. Spitznagel,et al.  Increasing Brain Tumor Rates: Is There a Link to Aspartame? , 1996, Journal of neuropathology and experimental neurology.

[28]  J J Strain,et al.  The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. , 1996, Analytical biochemistry.

[29]  H. Esterbauer,et al.  Continuous Monitoring of in Vztro Oxidation of Human Low Density Lipoprotein , 2009 .

[30]  H. Esterbauer,et al.  Continuous monitoring of in vitro oxidation of human low density lipoprotein. , 1989, Free radical research communications.

[31]  B. La Du,et al.  The human serum paraoxonase/arylesterase polymorphism. , 1983, American journal of human genetics.

[32]  N. Tolbert,et al.  A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. , 1978, Analytical biochemistry.

[33]  R. P. Noble.  Electrophoretic separation of plasma lipoproteins in agarose gel. , 1968, Journal of lipid research.

[34]  R. Havel,et al.  The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. , 1955, The Journal of clinical investigation.