Function and expression of the proton‐coupled amino acid transporter PAT1 along the rat gastrointestinal tract: implications for intestinal absorption of gaboxadol
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R Holm | A. Jensen | R. Holm | B. Brodin | M l Broberg | H Tønsberg | S Frølund | K B Ewon | A l Nielsen | B Brodin | A Jensen | M A Kall | K V Christensen | C U Nielsen | S. Frølund | H. Tønsberg | Alexander Nielsen | C. Nielsen | ML Broberg | KB Ewon | Maycraft Kall | KV Christensen
[1] Chih‐Yen Chen,et al. A novel simultaneous measurement method to assess the influence of intracerebroventricular obestatin on colonic motility and secretion in conscious rats , 2010, Peptides.
[2] K. G. Jensen,et al. 5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination. , 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[3] B. Larsen,et al. Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells. , 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[4] D. Thwaites,et al. Gamma‐aminobutyric acid (GABA) transport across human intestinal epithelial (Caco‐2) cell monolayers , 2000, British journal of pharmacology.
[5] C. Kilkenny,et al. Guidelines for reporting experiments involving animals: the ARRIVE guidelines , 2010, British journal of pharmacology.
[6] T. J. Cook,et al. Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 In Vitro cell culture model, and multiple human tissues , 2001, AAPS PharmSci.
[7] Y. Sai,et al. Biochemical and molecular pharmacological aspects of transporters as determinants of drug disposition. , 2005, Drug metabolism and pharmacokinetics.
[8] I. Cuthill,et al. Animal Research: Reporting In Vivo Experiments: The ARRIVE Guidelines , 2010, British journal of pharmacology.
[9] Stephen P. H. Alexander,et al. Guide to Receptors and Channels (GRAC), 5th edition , 2011, British journal of pharmacology.
[10] Guideline on the Investigation of Drug Interactions , 2010 .
[11] Hans Lennernäs,et al. Toward an increased understanding of the barriers to colonic drug absorption in humans: implications for early controlled release candidate assessment. , 2009, Molecular pharmaceutics.
[12] E. Woolf,et al. Development and validation of a selective and sensitive bioanalytical procedure for the quantitative determination of gaboxadol in human plasma employing mixed mode solid phase extraction and hydrophilic interaction liquid chromatography with tandem mass spectroscopic detection. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[13] D. Thwaites,et al. Vigabatrin transport across the human intestinal epithelial (Caco‐2) brush‐border membrane is via the H+‐coupled amino‐acid transporter hPAT1 , 2006, British journal of pharmacology.
[14] K. G. Jensen,et al. Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co‐administration of L‐tryptophan , 2009, British journal of pharmacology.
[15] P. M. Taylor,et al. H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat. , 2004, Gastroenterology.
[16] B. Brodin,et al. δ‐Aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1) , 2010, British journal of pharmacology.
[17] D. Thwaites,et al. The role of the proton electrochemical gradient in the transepithelial absorption of amino acids by human intestinal Caco-2 cell monolayers , 1995, The Journal of Membrane Biology.
[18] D. Thwaites,et al. H+‐coupled (Na+‐independent) proline transport in human intestinal (Caco‐2) epithelial cell monolayers , 1993, FEBS letters.
[19] J A Peters,et al. Guide to Receptors and Channels (GRAC), 3rd edition , 2008, British journal of pharmacology.
[20] J. Galloway,et al. Distribution of the H+/peptide transporter PepT1 in human intestine: up-regulated expression in the colonic mucosa of patients with short-bowel syndrome. , 2002, The American journal of clinical nutrition.
[21] P. Artursson,et al. Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[22] Draft Guidance,et al. Guidance for Industry Drug Interaction Studies — Study Design , Data Analysis , and Implications for Dosing and Labeling DRAFT GUIDANCE , 2006 .
[23] M. Niemi,et al. Membrane transporters in drug development , 2010, Nature Reviews Drug Discovery.
[24] Thomas D. Schmittgen,et al. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.
[25] H. Daniel,et al. Functional Characterization of Two Novel Mammalian Electrogenic Proton-dependent Amino Acid Cotransporters* , 2002, The Journal of Biological Chemistry.
[26] J. Walters,et al. Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl−-dependent TauT (SLC6A6) , 2008, The Journal of physiology.
[27] D. Kell,et al. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? , 2008, Nature Reviews Drug Discovery.
[28] H. Daniel,et al. Serotonin, l‐tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1 , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[29] Thomas D. Schmittgen,et al. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. , 2000, Analytical biochemistry.
[30] N. Rapin,et al. Gaboxadol has affinity for the proton-coupled amino acid transporter 1, SLC36A1 (hPAT1)--A modelling approach to determine IC(50) values of the three ionic species of gaboxadol. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[31] H. Daniel,et al. Kinetics of bidirectional H+ and substrate transport by the proton-dependent amino acid symporter PAT1. , 2005, The Biochemical journal.
[32] Li Di,et al. Coexistence of passive and carrier-mediated processes in drug transport , 2010, Nature Reviews Drug Discovery.
[33] H. Leffers,et al. Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats , 2010, BMC Neuroscience.
[34] A. Harmar,et al. New updated GRAC Fifth Edition with searchable online version Launch of new portal Guide to Pharmacology in association with NC‐IUPHAR Transporter‐Themed Issue , 2011, British journal of pharmacology.
[35] H. Yuasa. Drug Absorption from the Colon In Situ , 2008 .
[36] D. Thwaites,et al. Structure, function and immunolocalization of a proton‐coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco‐2 , 2003, The Journal of physiology.
[37] J. Walters,et al. Increased expression of specific intestinal amino acid and peptide transporter mRNA in rats fed by TPN is reversed by GLP-2. , 2004, The Journal of nutrition.
[38] A. Jensen,et al. Rectal Absorption of Vigabatrin, a Substrate of the Proton Coupled Amino Acid Transporter (PAT1, Slc36a1), in Rats , 2012, Pharmaceutical Research.
[39] R. Holm,et al. The proton‐coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly‐Gly, Gly‐Sar and other Gly‐Gly mimetics , 2010, British journal of pharmacology.
[40] Y. Sai,et al. PepT1 mRNA Expression Is Induced by Starvation and Its Level Correlates with Absorptive Transport of Cefadroxil Longitudinally in the Rat Intestine , 2002, Pharmaceutical Research.
[41] Supratim Choudhuri,et al. Structure, Function, Expression, Genomic Organization, and Single Nucleotide Polymorphisms of Human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) Efflux Transporters , 2006, International journal of toxicology.