Clinical trials in congestive heart failure: why do studies report conflicting results?

Excerpt As subscribers to peer-reviewed medical journals, we commonly read reports about advances in the treatment of acute and chronic diseases. Some reports describe highly favorable results and ...

[1]  J. Tobin,et al.  Diagnostic heterogeneity in clinical trials for congestive heart failure. , 1988, Annals of internal medicine.

[2]  M. Packer.  How should we judge the efficacy of drug therapy in patients with chronic congestive heart failure? The insights of six blind men. , 1987, Journal of the American College of Cardiology.

[3]  M. Packer,et al.  Role of the renin-angiotensin system in the development of hemodynamic and clinical tolerance to long-term prazosin therapy in patients with severe chronic heart failure. , 1986, Journal of the American College of Cardiology.

[4]  R. Gunnar,et al.  Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: a double-blind, randomized, placebo-controlled trial. , 1985, Circulation.

[5]  T. Ryan,et al.  Acute and long-term effects of enalapril on the cardiovascular response to exercise and exercise tolerance in patients with congestive heart failure. , 1985, Journal of the American College of Cardiology.

[6]  M. Shapiro,et al.  Scientific Misconduct in Investigations Drug Trials , 1985 .

[7]  C. Leier,et al.  Oral amrinone for the treatment of chronic congestive heart failure: results of a multicenter randomized double-blind and placebo-controlled withdrawal study. , 1984, Journal of the American College of Cardiology.

[8]  M. Wilén,et al.  Minoxidil in patients with chronic left heart failure: contrasting hemodynamic and clinical effects in a controlled trial. , 1984, Circulation.

[9]  J. Federman,et al.  Oral beta-adrenergic blockade with metoprolol in chronic severe dilated cardiomyopathy. , 1984, Journal of the American College of Cardiology.

[10]  B. Massie,et al.  Controlled Trial of Captopril in Chronic Heart Failure: A Rest and Exercise Hemodynamic Study , 1983, Circulation.

[11]  R. Magorien,et al.  Improved Exercise Capacity and Differing Arterial and Venous Tolerance During Chronic Isosorbide Dinitrate Therapy for Congestive Heart Failure , 1983, Circulation.

[12]  J. Cohn,et al.  Hydralazine in the long-term treatment of chronic heart failure: lack of difference from placebo. , 1982, American heart journal.

[13]  H. Ikram,et al.  DOUBLE-BLIND TRIAL OF CHRONIC ORAL BETA BLOCKADE IN CONGESTIVE CARDIOMYOPATHY , 1981, The Lancet.

[14]  R. Gorlin,et al.  Importance of left ventricular chamber size in determining the response to hydralazine in severe chronic heart failure. , 1980, The New England journal of medicine.