MRI‐based large deformation high dimensional mapping of the hippocampus in rats: Development and validation of the technique

To report the detection of structural and functional biological changes in living animals using small animal in vivo MRI that complements traditional ex vivo histological techniques. We report the development and validation of the application of large deformation high dimensional mapping (HDM‐LD) segmentation for the hippocampus in the rat.

[1]  Michael R. Salzberg,et al.  Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation , 2008, Experimental Neurology.

[2]  R. Hogan,et al.  Hippocampal deformation mapping in MRI negative PET positive temporal lobe epilepsy , 2007, Journal of Neurology, Neurosurgery, and Psychiatry.

[3]  Asla Pitkänen,et al.  Magnetic Resonance Imaging in Animal Models of Epilepsy—Noninvasive Detection of Structural Alterations , 2007, Epilepsia.

[4]  A. Toga,et al.  Multimodal, Multidimensional Models of Mouse Brain , 2007, Epilepsia.

[5]  R D Bucholz,et al.  Predictive value of hippocampal MR imaging-based high-dimensional mapping in mesial temporal epilepsy: preliminary findings. , 2006, AJNR. American journal of neuroradiology.

[6]  Bianca Jupp,et al.  Hippocampal T2 Signal Change during Amygdala Kindling Epileptogenesis , 2006, Epilepsia.

[7]  R. Hogan,et al.  Three‐dimensional deformation‐based hippocampal surface anatomy, projected on MRI images , 2005, Clinical anatomy.

[8]  Michiko Nakamura,et al.  MRI identification of dorsal hippocampus homologue in human brain , 2004, Neuroreport.

[9]  Lei Wang,et al.  MRI-based high-dimensional hippocampal mapping in mesial temporal lobe epilepsy. , 2004, Brain : a journal of neurology.

[10]  Michael I. Miller,et al.  Changes in hippocampal volume and shape across time distinguish dementia of the Alzheimer type from healthy aging☆ , 2003, NeuroImage.

[11]  Sarang Joshi,et al.  Hippocampal Deformation‐based Shape Analysis in Epilepsy and Unilateral Mesial Temporal Sclerosis , 2003, Epilepsia.

[12]  M. Miller,et al.  Statistical Analysis of Hippocampal Asymmetry in Schizophrenia , 2001, NeuroImage.

[13]  S. Joshi,et al.  Mesial temporal sclerosis and temporal lobe epilepsy: MR imaging deformation-based segmentation of the hippocampus in five patients. , 2000, Radiology.

[14]  U. Grenander,et al.  Computational anatomy: an emerging discipline , 1998 .

[15]  U. Grenander,et al.  Hippocampal morphometry in schizophrenia by high dimensional brain mapping. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[16]  George Bartzokis,et al.  Reliability of medial temporal lobe volume measurements using reformatted 3D images , 1998, Psychiatry Research: Neuroimaging.

[17]  Michael I. Miller,et al.  On The Geometry and Shape of Brain Sub-Manifolds , 1997, Int. J. Pattern Recognit. Artif. Intell..

[18]  C R Jack,et al.  Volumetric magnetic resonance imaging. Clinical applications and contributions to the understanding of temporal lobe epilepsy. , 1997, Archives of neurology.

[19]  Michael I. Miller,et al.  Volumetric transformation of brain anatomy , 1997, IEEE Transactions on Medical Imaging.

[20]  M W Vannier,et al.  Three-dimensional hippocampal MR morphometry with high-dimensional transformation of a neuroanatomic atlas. , 1997, Radiology.

[21]  U. Grenander.  Elements of Pattern Theory , 1996 .

[22]  G. Christensen,et al.  Hippocampal MR imaging morphometry by means of general pattern matching. , 1996, Radiology.

[23]  Michael I. Miller,et al.  Hierarchical brain mapping via a generalized Dirichlet solution for mapping brain manifolds , 1995, Optics & Photonics.

[24]  R. Rabbitt,et al.  3D brain mapping using a deformable neuroanatomy. , 1994, Physics in medicine and biology.

[25]  M I Miller,et al.  Mathematical textbook of deformable neuroanatomies. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Alan C. Evans,et al.  MRI of Amygdala and Hippocampus in Temporal Lobe Epilepsy , 1993, Journal of computer assisted tomography.

[27]  S. Medendorp,et al.  Magnetic resonance imaging lesion enlargement in multiple sclerosis. Disease-related activity, chance occurrence, or measurement artifact? , 1992, Archives of neurology.

[28]  M. Witter.  CHAPTER 21 – Hippocampal Formation , 2004 .

[29]  M. Miller,et al.  High-dimensional mapping of the hippocampus in depression. , 2003, The American journal of psychiatry.

[30]  Michael I. Miller,et al.  A deformable neuroanatomy textbook based on viscous uid mechanics , 1993 .

[31]  G. Paxinos.  The Rat nervous system , 1985 .

[32]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .