Enhancing cell recognition by scrutinizing cell surfaces with a nanoparticle array.

We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.

[1]  R. Weissleder,et al.  Cell-specific targeting of nanoparticles by multivalent attachment of small molecules , 2005, Nature Biotechnology.

[2]  Michael Hsiao,et al.  Enhancement of cell radiation sensitivity by pegylated gold nanoparticles , 2010, Physics in medicine and biology.

[3]  Y. J. Chen,et al.  Enhanced x-ray irradiation-induced cancer cell damage by gold nanoparticles treated by a new synthesis method of polyethylene glycol modification , 2008, Nanotechnology.

[4]  B. Yan,et al.  Structural confirmation and quantification of individual ligands from the surface of multi-functionalized gold nanoparticles. , 2010, The Analyst.

[5]  R. Bellamkonda,et al.  A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[6]  Ruxandra Gref,et al.  Polysaccharide-decorated nanoparticles. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[7]  Xian‐Zheng Zhang,et al.  Dual targeting of a thermosensitive nanogel conjugated with transferrin and RGD-containing peptide for effective cell uptake and drug release , 2009, Nanotechnology.

[8]  Anthony D. Keefe,et al.  Aptamers as therapeutics , 2010, Nature Reviews Drug Discovery.

[9]  E. Kokkoli,et al.  Peptide- and aptamer-functionalized nanovectors for targeted delivery of therapeutics. , 2009, Journal of biomechanical engineering.

[10]  Yi Lu,et al.  Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates. , 2010, Advanced drug delivery reviews.

[11]  Hongyu Zhou,et al.  Functionalized carbon nanotubes specifically bind to alpha-chymotrypsin's catalytic site and regulate its enzymatic function. , 2009, Nano letters.

[12]  Hak Soo Choi,et al.  Design considerations for tumour-targeted nanoparticles. , 2010, Nature nanotechnology.

[13]  Hongyu Zhou,et al.  A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune response. , 2008, Nano letters.

[14]  Yan Zhang,et al.  Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[15]  N. Oku,et al.  A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy. , 2010, Cancer letters.

[16]  Jie Chen,et al.  Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles. , 2008, Small.

[17]  J. Ross,et al.  Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications , 1994, Cancer.

[18]  P. Ray,et al.  Aptamers for Targeted Drug Delivery , 2010, Pharmaceuticals.

[19]  C. Blondin,et al.  Polysaccharides for vascular cell targeting. , 2000, Critical reviews in therapeutic drug carrier systems.

[20]  V. Torchilin Antibody-modified liposomes for cancer chemotherapy , 2008, Expert opinion on drug delivery.

[21]  Seulki Lee,et al.  Peptide-based probes for targeted molecular imaging. , 2010, Biochemistry.

[22]  W. Gunning,et al.  Expression of folate receptor type alpha in relation to cell type, malignancy, and differentiation in ovary, uterus, and cervix. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[23]  Moshi Geso,et al.  Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy. , 2009, Nanomedicine : nanotechnology, biology, and medicine.

[24]  Klaas Nicolay,et al.  Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis. , 2010, Nano letters.

[25]  I. García,et al.  Glyconanoparticles: multifunctional nanomaterials for biomedical applications. , 2010, Nanomedicine.